Results 31 to 40 of about 2,772 (166)
Adaptive thermogenesis in brown adipose tissue involves activation of pannexin-1 channels
Molecular Metabolism, 2021 Objective: Brown adipose tissue (BAT) is specialized in thermogenesis. The conversion of energy into heat in brown adipocytes proceeds via stimulation of β-adrenergic receptor (βAR)-dependent signaling and activation of mitochondrial uncoupling protein 1
Subramanian Senthivinayagam +20 more
doaj +1 more source
Cells, 2022 Enhanced activity and overexpression of Pannexin 1 (Panx1) channels contribute to neuronal pathologies such as epilepsy and Alzheimer’s disease (AD). The Panx1 channel ablation alters the hippocampus’s glutamatergic neurotransmission, synaptic plasticity,
Carolina Flores-Muñoz +11 more
doaj +1 more source
Pannexin 1 channels in skeletal muscles
Frontiers in Physiology, 2014 Normal myotubes and adult innervated skeletal myofibers express the glycoprotein pannexin1 (Panx1). Six of them form a gap junction hemichannel-like structure that connects the cytoplasm with the extracellular space; here they will be called Panx1 ...
Luis Andrés Cea +6 more
doaj +1 more source
ATP triggers macropinocytosis that internalizes and is regulated by PANX1 [PDF]
, 2020 ABSTRACT Macropinocytosis is an endocytic process that allows cells to respond to changes in their environment by internalizing nutrients and cell surface proteins, as well as modulating cell size. Here, we identify that adenosine triphosphate (ATP) triggers macropinocytosis in murine neuroblastoma cells, thereby internalizing the ATP ...
Andrew K.J. Boyce +3 more
openaire +1 more source
Cell Reports, 2023 Summary: Neuronal swelling during cytotoxic edema is triggered by Na+ and Cl− entry and is Ca2+ independent. However, the causes of neuronal death during swelling are unknown. Here, we investigate the role of large-conductance Pannexin-1 (Panx1) channels
Nicholas L. Weilinger +15 more
doaj +1 more source
Powerful partnership: crosstalk between pannexin 1 and the cytoskeleton
Frontiers in Physiology, 2014 Pannexin 1 (Panx1) large-pore ion and metabolite channels are emerging as key proteins in many physiological and pathophysiological scenarios. Recent evidence has tightly linked Panx1 trafficking and function to the cytoskeleton, a multi-component ...
Andrew Kenneth Jameson Boyce +5 more
doaj +1 more source
Contribution of pannexin1 to experimental autoimmune encephalomyelitis. [PDF]
PLoS ONE, 2013 Pannexin1 (Panx1) is a plasma membrane channel permeable to relatively large molecules, such as ATP. In the central nervous system (CNS) Panx1 is found in neurons and glia and in the immune system in macrophages and T-cells. We tested the hypothesis that
Sarah E Lutz +10 more
doaj +1 more source
Selective inhibition of Panx1 channels decreases hemostasis and thrombosis in vivo [PDF]
Thrombosis Research, 2019 Hemostasis is a tightly regulated physiological process to rapidly induce hemostatic plugs at sites of vascular injury. Inappropriate activation of this process may lead to thrombosis, i.e. pathological blood clot formation in uninjured vessels or on atherosclerotic lesions.
Molica, Filippo +9 more
openaire +4 more sources
Frontiers in Immunology, 2023 Sepsis represents a global health concern, and patients with severe sepsis are at risk of experiencing MODS (multiple organ dysfunction syndrome), which is associated with elevated mortality rates and a poorer prognosis.
Xiangyu Chen +4 more
doaj +1 more source
PANX1- Immunosuppressive tumor microenvironment (TME)
, 2021 Research Data for PANX1- Immunosuppressive tumor microenvironment (TME ...
openaire +6 more sources