Mouse Panx1 Is Dispensable for Hearing Acquisition and Auditory Function [PDF]
Frontiers in Molecular Neuroscience, 2017 Panx1 forms plasma membrane channels in brain and several other organs, including the inner ear. Biophysical properties, activation mechanisms and modulators of Panx1 channels have been characterized in detail, however the impact of Panx1 on auditory ...
Veronica Zorzi +23 more
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Neuronal Panx1 drives peripheral sensitization in experimental plantar inflammatory pain
Military Medical ResearchBackground The channel-forming protein Pannexin1 (Panx1) has been implicated in both human studies and animal models of chronic pain, but the underlying mechanisms remain incompletely understood.
Qu Xing +7 more
doaj +4 more sources
Loss of Panx1 Impairs Mammary Gland Development at Lactation: Implications for Breast Tumorigenesis. [PDF]
PLoS ONE, 2016 Pannexin1 (Panx1) subunits oligomerize to form large-pore channels between the intracellular and extracellular milieu that have been shown to regulate proliferation, differentiation and cell death mechanisms.
Michael K G Stewart +3 more
doaj +7 more sources
Astrocyte and Neuronal Panx1 Support Long-Term Reference Memory in Mice
ASN Neuro, 2023 Pannexin 1 (Panx1) is an ubiquitously expressed protein that forms plasma membrane channels permeable to anions and moderate-sized signaling molecules (e.g., ATP, glutamate).
Price Obot +7 more
doaj +5 more sources
Cationic control of Panx1 channel function [PDF]
American Journal of Physiology-Cell Physiology, 2018 The sequence and predicted membrane topology of pannexin1 (Panx1) places it in the family of gap junction proteins. However, rather than forming gap junction channels, Panx1 forms channels in the nonjunctional membrane.
Dahl, Gerhard +5 more
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PANX1- Immunosuppressive tumor microenvironment (TME)
, 2021 Research Data for PANX1- Immunosuppressive tumor microenvironment (TME ...
Wuzhen Chen
core +8 more sources
Differential Activation of Mouse and Human Panx1 Channel Variants
PLOS ONE, 2023 Pannexins are ubiquitously expressed in human and mouse tissues. Pannexin 1 (Panx1), the most thoroughly characterized member of this family, forms plasmalemmal membrane channels permeable to relatively large molecules, such as ATP.
Cibelli, Antonio +4 more
core +5 more sources
Normal Taste Acceptance and Preference of PANX1 Knockout Mice [PDF]
Chemical Senses, 2015 Taste compounds detected by G protein-coupled receptors on the apical surface of Type 2 taste cells initiate an intracellular molecular cascade culminating in the release of ATP.
Matsumoto, Ichiro +8 more
core +3 more sources
The impact of Panx1 on inflammation, immunity, and cancer: a comprehensive review [PDF]
Frontiers in MedicinePannexin 1 (Panx1) is a widely expressed membrane channel that regulates ATP release and purinergic signaling, playing essential roles in inflammation, immunity, and tumor progression. This review provides a comprehensive analysis of its structure, activation mechanisms, and its functional relevance in both innate and adaptive immunity.
Claudio Acuña-Castillo
exaly +4 more sources
Selective Inhibition of Panx1 Channels Decreases Hemostasis and Thrombosis in vivo [PDF]
Thrombosis Research, 2019 BACKGROUND: Hemostasis is a tightly regulated physiological process to rapidly induce hemostatic plugs at sites of vascular injury. Inappropriate activation of this process may lead to thrombosis, i.e.
Meens, Merlijn J. +12 more
core +5 more sources