Mouse Panx1 Is Dispensable for Hearing Acquisition and Auditory Function [PDF]
Frontiers in Molecular Neuroscience, 2017 Panx1 forms plasma membrane channels in brain and several other organs, including the inner ear. Biophysical properties, activation mechanisms and modulators of Panx1 channels have been characterized in detail, however the impact of Panx1 on auditory ...
Veronica Zorzi +23 more
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Loss of Panx1 Impairs Mammary Gland Development at Lactation: Implications for Breast Tumorigenesis. [PDF]
PLoS ONE, 2016 Pannexin1 (Panx1) subunits oligomerize to form large-pore channels between the intracellular and extracellular milieu that have been shown to regulate proliferation, differentiation and cell death mechanisms.
Michael K G Stewart +3 more
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Astrocyte and Neuronal Panx1 Support Long-Term Reference Memory in Mice
ASN Neuro, 2023 Pannexin 1 (Panx1) is an ubiquitously expressed protein that forms plasma membrane channels permeable to anions and moderate-sized signaling molecules (e.g., ATP, glutamate).
Price Obot +7 more
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Neuronal Panx1 drives peripheral sensitization in experimental plantar inflammatory pain
Military Medical ResearchBackground The channel-forming protein Pannexin1 (Panx1) has been implicated in both human studies and animal models of chronic pain, but the underlying mechanisms remain incompletely understood.
Qu Xing +7 more
doaj +3 more sources
Apically localized PANX1 impacts neuroepithelial expansion in human cerebral organoids
Cell Death DiscoveryDysfunctional paracrine signaling through Pannexin 1 (PANX1) channels is linked to several adult neurological pathologies and emerging evidence suggests that PANX1 plays an important role in human brain development.
Rebecca J. Noort +5 more
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Cationic control of Panx1 channel function [PDF]
American Journal of Physiology-Cell Physiology, 2018 The sequence and predicted membrane topology of pannexin1 (Panx1) places it in the family of gap junction proteins. However, rather than forming gap junction channels, Panx1 forms channels in the nonjunctional membrane. Panx1 operates in two distinct open states, depending on the mode of stimulation.
Junjie, Wang +2 more
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Structural basis of PANX1 permeation and positive modulation by mefloquine. [PDF]
Nat CommunPurinergic signaling relies on ATP release through exocytosis and large-pore channels. Large-pore channels permeate both small anions like chloride and large signaling molecules like ATP, but how this broad cargo selectivity is structurally controlled remains elusive.
Li Y +6 more
europepmc +3 more sources
Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury. [PDF]
PLoS ONE, 2012 Pannexin1 (Panx1) forms large nonselective membrane channel that is implicated in paracrine and inflammatory signaling. In vitro experiments suggested that Panx1 could play a key role in ischemic death of hippocampal neurons. Since retinal ganglion cells
Galina Dvoriantchikova +6 more
doaj +1 more source
Endothelial pannexin 1–TRPV4 channel signaling lowers pulmonary arterial pressure in mice
eLife, 2021 Pannexin 1 (Panx1), an ATP-efflux pathway, has been linked with inflammation in pulmonary capillaries. However, the physiological roles of endothelial Panx1 in the pulmonary vasculature are unknown.
Zdravka Daneva +10 more
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Pannexin-1 Contributes to the Apoptosis of Spinal Neurocytes in Spinal Cord Injury
Frontiers in Physiology, 2021 Currently, the role of Pannexin-1, a homomeric membrane hemichannel on the neuron cell membrane, in the development of spinal cord injury (SCI) is largely unknown. Herein, we assessed the contribution of Panx1 in the development of SCI.
Yu Huang +3 more
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