Results 21 to 30 of about 2,772 (166)

Inhibition of the P2X7–PANX1 complex suppresses spreading depolarization and neuroinflammation [PDF]

Brain, 2017
Abstract Spreading depolarization is a wave of neuronal and glial depolarization. Within minutes after spreading depolarization, the neuronal hemichannel pannexin 1 (PANX1) opens and forms a pore complex with the ligand-gated cation channel P2X7, allowing the release of excitatory neurotransmitters to sustain spreading depolarization ...
Chen, S.P., Qin, T., Seidel, J.L., Zheng, Y., Eikermann, M., Ferrari, M.D., Maagdenberg, A.M.J.M. van den, Moskowitz, M.A., Ayata, C., Eikermann-Haerter, K.   +9 more
openaire   +3 more sources

Stomatin inhibits pannexin-1-mediated whole-cell currents by interacting with its carboxyl terminal. [PDF]

PLoS ONE, 2012
The pannexin-1 (Panx1) channel (often referred to as the Panx1 hemichannel) is a large-conductance channel in the plasma membrane of many mammalian cells.
Haiying Zhan, Craig S Moore, Bojun Chen, Xin Zhou, Xin-Ming Ma, Kumiko Ijichi, Michael V L Bennett, Xue-Jun Li, Stephen J Crocker, Zhao-Wen Wang   +9 more
doaj   +1 more source

Pannexin 1 Influences Lineage Specification of Human iPSCs

Frontiers in Cell and Developmental Biology, 2021
Every single cell in the body communicates with nearby cells to locally organize activities with their neighbors and dysfunctional cell-cell communication can be detrimental during cell lineage commitment, tissue patterning and organ development ...
Rebecca J. Noort, Grace A. Christopher, Jessica L. Esseltine   +2 more
doaj   +1 more source

Panx1 promotes invasion-metastasis cascade in hepatocellular carcinoma [PDF]

Journal of Cancer, 2019
Background: The molecular function of pannexin1 (Panx1) in different tumor types has been remained equivocal. Until now, there is no study focused on the function of panx1 in hepatocellular carcinoma (HCC). This study aimed to explore the role of Panx1 in the invasion and metastasis of HCC.
Shi, Guangjun, Liu, Chuanliang, Yang, Yiming, Song, Liwei, Liu, Xueni, Wang, Chuanxu, Peng, Zhihai, Li, Hao, Zhong, Lin   +8 more
openaire   +2 more sources

Expression of Pannexin 1 in the Human Kidney during Embryonal, Early Fetal and Postnatal Development and Its Prognostic Significance in Diabetic Nephropathy

Biomedicines, 2022
Pannexins are transmembrane glycoproteins that constitute channels involved in purinergic signaling through ATP release from cells in various physiological and pathological processes.
Ivo Jeličić, Katarina Vukojević, Anita Racetin, Davor Čarić, Merica Glavina Durdov, Mirna Saraga-Babić, Natalija Filipović   +6 more
doaj   +1 more source

Pannexin-1 Modulates Inhibitory Transmission and Hippocampal Synaptic Plasticity

Biomolecules, 2023
Pannexin-1 (Panx1) hemichannel is a non-selective transmembrane channel that may play important roles in intercellular signaling by allowing the permeation of ions and metabolites, such as ATP. Although recent evidence shows that the Panx1 hemichannel is
Francisca García-Rojas, Carolina Flores-Muñoz, Odra Santander, Pamela Solis, Agustín D. Martínez, Álvaro O. Ardiles, Marco Fuenzalida   +6 more
doaj   +1 more source

Differential activation of mouse and human Panx1 channel variants

PLOS ONE, 2023
Pannexins are ubiquitously expressed in human and mouse tissues. Pannexin 1 (Panx1), the most thoroughly characterized member of this family, forms plasmalemmal membrane channels permeable to relatively large molecules, such as ATP.
Antonio Cibelli, Preeti Dohare, David C. Spray, Eliana Scemes   +3 more
openaire   +4 more sources

SCAM analysis of Panx1 suggests a peculiar pore structure [PDF]

Journal of General Physiology, 2010
Vertebrates express two families of gap junction proteins: the well-characterized connexins and the pannexins. In contrast to connexins, pannexins do not appear to form gap junction channels but instead function as unpaired membrane channels. Pannexins have no sequence homology to connexins but are distantly related to the invertebrate gap junction ...
Wang, Junjie, Dahl, Gerhard
openaire   +2 more sources

Normal Taste Acceptance and Preference of PANX1 Knockout Mice [PDF]

Chemical Senses, 2015
Taste compounds detected by G protein-coupled receptors on the apical surface of Type 2 taste cells initiate an intracellular molecular cascade culminating in the release of ATP. It has been suggested that this ATP release is accomplished by pannexin 1 (PANX1).
Michael G, Tordoff, Tiffany R, Aleman, Hillary T, Ellis, Makoto, Ohmoto, Ichiro, Matsumoto, Val I, Shestopalov, Claire H, Mitchell, J Kevin, Foskett, Rachel L, Poole   +8 more
openaire   +2 more sources

Mechanisms of Pannexin 1 (PANX1) Channel Mechanosensitivity and Its Pathological Roles [PDF]

International Journal of Molecular Sciences, 2022
Pannexins (PANX) were cloned based on their sequence homology to innexins (Inx), invertebrate gap junction proteins. Although there is no sequence homology between PANX and connexins (Cx), these proteins exhibit similar configurations. The PANX family has three members, PANX1, PANX2 and PANX3.
Yang, Kai, Xiao, Zhupeng, He, Xueai, Weng, Ruotong, Zhao, Xinyue, Sun, Taolei   +5 more
openaire   +2 more sources