Results 21 to 30 of about 3,650 (196)

SCAM analysis of Panx1 suggests a peculiar pore structure [PDF]

Journal of General Physiology, 2010
Vertebrates express two families of gap junction proteins: the well-characterized connexins and the pannexins. In contrast to connexins, pannexins do not appear to form gap junction channels but instead function as unpaired membrane channels.
Dahl, Gerhard, Gerhard Dahl, Junjie Wang, Wang, Junjie   +3 more
core   +3 more sources

Mechanisms of Pannexin 1 (PANX1) Channel Mechanosensitivity and Its Pathological Roles [PDF]

International Journal of Molecular Sciences, 2022
Pannexins (PANX) were cloned based on their sequence homology to innexins (Inx), invertebrate gap junction proteins. Although there is no sequence homology between PANX and connexins (Cx), these proteins exhibit similar configurations.
Kai Yang, Ruotong Weng, Taolei Sun, Xinyue Zhao, Zhupeng Xiao, Xueai He   +5 more
core   +3 more sources

Apically localized PANX1 impacts neuroepithelial expansion in human cerebral organoids

Cell Death Discovery
Dysfunctional paracrine signaling through Pannexin 1 (PANX1) channels is linked to several adult neurological pathologies and emerging evidence suggests that PANX1 plays an important role in human brain development.
Rebecca J. Noort, Hanrui Zhu, Robert T. Flemmer, Craig S. Moore, Thomas J. Belbin, Jessica L. Esseltine   +5 more
doaj   +3 more sources

Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury. [PDF]

PLoS ONE, 2012
Pannexin1 (Panx1) forms large nonselective membrane channel that is implicated in paracrine and inflammatory signaling. In vitro experiments suggested that Panx1 could play a key role in ischemic death of hippocampal neurons. Since retinal ganglion cells
Galina Dvoriantchikova, Dmitry Ivanov, David Barakat, Alexander Grinberg, Rong Wen, Vladlen Z Slepak, Valery I Shestopalov   +6 more
doaj   +1 more source

Endothelial pannexin 1–TRPV4 channel signaling lowers pulmonary arterial pressure in mice

eLife, 2021
Pannexin 1 (Panx1), an ATP-efflux pathway, has been linked with inflammation in pulmonary capillaries. However, the physiological roles of endothelial Panx1 in the pulmonary vasculature are unknown.
Zdravka Daneva, Matteo Ottolini, Yen Lin Chen, Eliska Klimentova, Maniselvan Kuppusamy, Soham A Shah, Richard D Minshall, Cheikh I Seye, Victor E Laubach, Brant E Isakson, Swapnil K Sonkusare   +10 more
doaj   +1 more source

Stomatin inhibits pannexin-1-mediated whole-cell currents by interacting with its carboxyl terminal. [PDF]

PLoS ONE, 2012
The pannexin-1 (Panx1) channel (often referred to as the Panx1 hemichannel) is a large-conductance channel in the plasma membrane of many mammalian cells.
Haiying Zhan, Craig S Moore, Bojun Chen, Xin Zhou, Xin-Ming Ma, Kumiko Ijichi, Michael V L Bennett, Xue-Jun Li, Stephen J Crocker, Zhao-Wen Wang   +9 more
doaj   +1 more source

Pannexin 1 Influences Lineage Specification of Human iPSCs

Frontiers in Cell and Developmental Biology, 2021
Every single cell in the body communicates with nearby cells to locally organize activities with their neighbors and dysfunctional cell-cell communication can be detrimental during cell lineage commitment, tissue patterning and organ development ...
Rebecca J. Noort, Grace A. Christopher, Jessica L. Esseltine   +2 more
doaj   +1 more source

Panx1 promotes invasion-metastasis cascade in hepatocellular carcinoma [PDF]

Journal of Cancer, 2019
Background: The molecular function of pannexin1 (Panx1) in different tumor types has been remained equivocal. Until now, there is no study focused on the function of panx1 in hepatocellular carcinoma (HCC). This study aimed to explore the role of Panx1 in the invasion and metastasis of HCC.
Shi, Guangjun, Liu, Chuanliang, Yang, Yiming, Song, Liwei, Liu, Xueni, Wang, Chuanxu, Peng, Zhihai, Li, Hao, Zhong, Lin   +8 more
openaire   +2 more sources

Expression levels of mouse and human Panx1.

, 2023
(A) Mean ± SEM values of the relative expression levels of Panx1 transcripts obtained by q-RT-PCR performed in N2a cell expressing endogenous mPanx1 (parental), N2a lacking Panx1 (Panx1-null), and in N2a expressing human wildtype Panx1 (hPanx1) and two ...
Preeti Dohare (17655559), David C. Spray (294210), Antonio Cibelli (8847641), Eliana Scemes (204874)   +3 more
core   +1 more source

Expression of Pannexin 1 in the Human Kidney during Embryonal, Early Fetal and Postnatal Development and Its Prognostic Significance in Diabetic Nephropathy

Biomedicines, 2022
Pannexins are transmembrane glycoproteins that constitute channels involved in purinergic signaling through ATP release from cells in various physiological and pathological processes.
Ivo Jeličić, Katarina Vukojević, Anita Racetin, Davor Čarić, Merica Glavina Durdov, Mirna Saraga-Babić, Natalija Filipović   +6 more
doaj   +1 more source