Results 51 to 60 of about 3,650 (196)

Promises and pitfalls of a Pannexin1 transgenic mouse line.

Frontiers in Pharmacology, 2013
Gene targeting strategies have become a powerful technology for elucidating mammalian gene function. The recently generated knockout (KO)-first strategy produces a knockout at the RNA processing level and also allows for the generation of conditional KO ...
Regina eHanstein, Hiromitsu eNegoro, Naman K. Patel, Anne eCharollais, Paolo eMeda, David C. Spray, Sylvia O. Suadicani, Eliana eScemes   +7 more
doaj   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). I. Treatments in preclinical and early clinical development

Epilepsia, EarlyView.
Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Delayed onset of EAE in Panx1 KO mice.

, 2013
(A - right) Time course of clinical signs recorded from Panx1 wild type (WT) and Panx1 knockout (KO) mice immunized for MOG. (A-left) The graph depicts the initial acute phase of the disease (blue rectangle in A) showing that up to day 12 post ...
Sylvia O. Suadicani (424633), Leonid Tarassishin (326809), Juan Carlos Chara Ventura (424630), Naman K. Patel (204869), Sarah E. Lutz (204871), Hiromitsu Negoro (424632), Sunhee C. Lee (326811), Carlos Matute (201313), Eliana Scemes (204874), Estibaliz González-Fernández (424629), Alberto Pérez-Samartín (424631)   +10 more
core   +1 more source

The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity

Epilepsia Open, EarlyView.
Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Mohammad Reza Seyedtaghia, Jina Babanzadeh, Marcello Scala, Lorenzo Perilli, Pasquale Striano   +4 more
wiley   +1 more source

Pannexin-1 Channels Are Essential for Mast Cell Degranulation Triggered During Type I Hypersensitivity Reactions

Frontiers in Immunology, 2019
Mast cells (MCs) release pro-inflammatory mediators through a process called degranulation response. The latter may be induced by several conditions, including antigen recognition through immunoglobulin E (IgE) or “cross-linking,” classically associated ...
Paloma A. Harcha, Paloma A. Harcha, Ximena López, Ximena López, Pablo J. Sáez, Pablo J. Sáez, Pablo J. Sáez, Paola Fernández, Iván Barría, Agustín D. Martínez, Juan C. Sáez, Juan C. Sáez   +11 more
doaj   +1 more source

The role of extracellular vesicles in cell–cell crosstalk in cardiotoxicity

The Journal of Physiology, EarlyView.
Abstract figure legend Administration of a pharmacological agent can result in off‐target cardiotoxicity which can be driven by cell–cell crosstalk between healthy and dysfunctional cardiac cells. Extracellular vesicles (EVs) are lipid bilayer structures that can move biological cargo between cells, facilitating cell–cell crosstalk.
Gabriella Bachynskyj‐Bilas, Debbie J. Otto, Daniel Stratton, Katja Rietdorf, Daniel M. Johnson, Calum J. McMullen   +5 more
wiley   +1 more source

Inhibition of PANX1 Channels Reduces the Malignant Properties of Human High-Risk Neuroblastoma

Journal of Cancer, 2023
Pannexin 1 (PANX1) is expressed in many tissue types including tissues of neural origin. Neuroblastoma (NB) is a neural crest-derived malignancy mainly occurring in children. The majority of NB patients present with high-risk disease for which current therapies are ineffective. Here, we show that while PANX1 is expressed in NB of all stages, high PANX1
Langlois, Stéphanie, St-Pierre, Marie-Eve, Holland, Stephen H., Xiang, Xiao, Freeman, Emily, Mohamed, Hisham, Dural, Ahmet Cem, Hammad, Ahmed, Karami, Sanaz, van de Panne, Chloé, Cowan, Kyle N.   +10 more
openaire   +2 more sources

TNFSF14/LIGHT responses in intestinal and oesophageal fibroblasts are differentially modulated by hydroxylase inhibitors

The Journal of Physiology, EarlyView.
Abstract figure legend LIGHT is a mutual mediator of intestinal and oesophageal fibroblast inflammation with common as well as tissue‐specific effects. Hydroxylase inhibitors can selectively suppress inflammatory factors in both cell types, albeit targeting different signalling pathways.
Cian M. Ohlendieck, Carlos Matellan, Cristina Bauset, Bella Raphael, Mary Nwaezeigwe, Emer Flynn, Kevin Okamoto, Desmond Winter, Colm Collins, Katie Doogan, Seán T. Martin, Glen Doherty, Seema S. Aceves, Mario C. Manresa   +13 more
wiley   +1 more source

Sequences of mouse and wildtype human Panx1 and variants.

, 2023
(A) Comparison between amino acid sequences of mouse and human pannexin proteins. In red are amino acids found in human Panx1 that differ from those found in mouse. (B).
Preeti Dohare (17655559), David C. Spray (294210), Antonio Cibelli (8847641), Eliana Scemes (204874)   +3 more
core   +1 more source

Intracellular Cysteine 346 Is Essentially Involved in Regulating Panx1 Channel Activity [PDF]

Journal of Biological Chemistry, 2010
Pannexins constitute a family of proteins exhibiting predominantly hemichannel activity. Pannexin channels have been suggested to participate in a wide spectrum of biological functions such as propagation of calcium waves, release of IL-1β, and responses to ischemic conditions.
Stefanie, Bunse, Matthias, Schmidt, Nora, Prochnow, Georg, Zoidl, Rolf, Dermietzel   +4 more
openaire   +2 more sources