Results 51 to 60 of about 2,772 (166)

Intracellular Cysteine 346 Is Essentially Involved in Regulating Panx1 Channel Activity [PDF]

Journal of Biological Chemistry, 2010
Pannexins constitute a family of proteins exhibiting predominantly hemichannel activity. Pannexin channels have been suggested to participate in a wide spectrum of biological functions such as propagation of calcium waves, release of IL-1β, and responses to ischemic conditions.
Stefanie, Bunse, Matthias, Schmidt, Nora, Prochnow, Georg, Zoidl, Rolf, Dermietzel   +4 more
openaire   +2 more sources

Hepatic pannexin‐1 mediates ST2+ regulatory T cells promoting resolution of inflammation in lipopolysaccharide‐induced endotoxemia

Clinical and Translational Medicine, 2022
Sepsis remains the most lethal infectious disease and substantially impairs patient prognosis after liver transplantation (LT). Our previous study reported a role of the pannexin 1 (PANX1)–interleukin‐33 (IL‐33) axis in activating innate immunity to ...
Pusen Wang, Baojie Shi, Chunguang Wang, Yuanyuan Wang, Weitao Que, Zhongyi Jiang, Xueni Liu, Qianwei Jiang, Hao Li, Zhihai Peng, Lin Zhong   +10 more
doaj   +1 more source

Overlap in synaptic neurological condition susceptibility pathways and the neural pannexin 1 interactome revealed by bioinformatics analyses

Channels, 2023
Many neurological conditions exhibit synaptic impairments, suggesting mechanistic convergence. Additionally, the pannexin 1 (PANX1) channel and signaling scaffold is linked to several of these neurological conditions and is an emerging regulator of ...
Simona D Frederiksen, Leigh E Wicki-Stordeur, Leigh Anne Swayne   +2 more
doaj   +1 more source

PANX2 Suppresses Lung Adenocarcinoma Progression by Inducing Disulfidptosis and Enhancing Antitumor Immunity

Advanced Science, Volume 13, Issue 44, 7 August 2026.
ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen, Zhao‐Yu Liu, Gao‐Wen Qu, Run‐Hao Zeng, Wen‐Xia Yao, Yong‐Bing Zhou, Xue Liang, Yu‐Xiong Lai   +7 more
wiley   +1 more source

Astrocyte Mechanobiology: Linking Biomechanical Forces to Biochemical Signaling in the Central Nervous System

Glia, Volume 74, Issue 7, July 2026.
Astrocytes are key sensors and transducers of biomechanical stimuli within the central nervous system. Astrocyte development is highly dependent on mechanical stimuli such as surrounding tissue stiffness and biomechanical strain. Mechanosensory pathways including integrins, connexins and pannexins, and mechanosensitive channels regulate astrocyte ...
Ana N. Strat, Alima Ahmed, Mariano Viapiano, Preethi S. Ganapathy   +3 more
wiley   +1 more source

Pannexin 1 dysregulation in Duchenne muscular dystrophy and its exacerbation of dystrophic features in mdx mice

Skeletal Muscle
Background Duchenne muscular dystrophy (DMD) is associated with impaired muscle regeneration, progressive muscle weakness, damage, and wasting. While the cause of DMD is an X-linked loss of function mutation in the gene encoding dystrophin, the exact ...
Emily Freeman, Stéphanie Langlois, Marcos F. Leyba, Tarek Ammar, Zacharie Léger, Hugh J. McMillan, Jean-Marc Renaud, Bernard J. Jasmin, Kyle N. Cowan   +8 more
doaj   +1 more source

Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes

Molecular Metabolism, 2015
Objective: Defective glucose uptake in adipocytes leads to impaired metabolic homeostasis and insulin resistance, hallmarks of type 2 diabetes. Extracellular ATP-derived nucleotides and nucleosides are important regulators of adipocyte function, but the ...
Samantha E. Adamson, Akshaya K. Meher, Yu-hsin Chiu, Joanna K. Sandilos, Nathaniel P. Oberholtzer, Natalie N. Walker, Stefan R. Hargett, Scott A. Seaman, Shayn M. Peirce-Cottler, Brant E. Isakson, Coleen A. McNamara, Susanna R. Keller, Thurl E. Harris, Douglas A. Bayliss, Norbert Leitinger   +14 more
doaj   +1 more source

Molecular Mechanism of the IRF1/NFE2L1‐DT/ALKBH5/Cx43 Axis in Radiation‐Induced Injury in Vascular Endothelial Cells Through Pyroptosis

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 7, July 2026.
ABSTRACT Radiotherapy effectively eradicates tumor cells but can also trigger pyroptotic damage in vascular endothelial cells. This study investigates the role of interferon regulatory factor 1 (IRF1) in radiation‐induced endothelial injury, aiming to provide mechanistic insights for optimizing radiotherapy.
Chen Li, Jia‐Wen Yang, Yong‐Rui Jia, Jie Zhang, Qiao Gou   +4 more
wiley   +1 more source

When can AlphaFold predict the oligomeric states of proteins?

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Homooligomerisation is a prevalent and important process that many proteins undergo to form the quaternary structures required for biological function. However, determining oligomeric states and structures experimentally remains technically challenging and time‐consuming for many proteins.
Yiechang Lin, Ciara Wallis, Ben Corry
wiley   +1 more source

Amino acid modulation of the carotid body selectively modulates peripheral chemoreceptor respiratory reflex

The Journal of Physiology, Volume 604, Issue 14, Page 6196-6224, 15 July 2026.
Abstract figure legend When the carotid body (CB) detects low oxygen levels (hypoxia), this leads to: (1) depolarization of the chemosensory cells (glomus cells) within the CB – the resulting increase in intracellular Ca2+ stimulates the exocytotic co‐release of vesicles containing ATP and glutamate; (2) synaptic ATP acts on postsynaptic petrosal ...
Olivia M. S. Gold, Audrys G. Pauza, Igor S. A. Felippe, Xin Shen, Julian F. R. Paton   +4 more
wiley   +1 more source