Results 51 to 60 of about 3,413 (197)
The role of extracellular vesicles in cell–cell crosstalk in cardiotoxicity
The Journal of Physiology, EarlyView.Abstract figure legend Administration of a pharmacological agent can result in off‐target cardiotoxicity which can be driven by cell–cell crosstalk between healthy and dysfunctional cardiac cells. Extracellular vesicles (EVs) are lipid bilayer structures that can move biological cargo between cells, facilitating cell–cell crosstalk.
Gabriella Bachynskyj‐Bilas +5 more
wiley +1 more source
Glia, Volume 74, Issue 7, July 2026.Astrocytes are key sensors and transducers of biomechanical stimuli within the central nervous system. Astrocyte development is highly dependent on mechanical stimuli such as surrounding tissue stiffness and biomechanical strain. Mechanosensory pathways including integrins, connexins and pannexins, and mechanosensitive channels regulate astrocyte ...
Ana N. Strat +3 more
wiley +1 more source
The Journal of Physiology, Volume 604, Issue 12, Page 4678-4706, 15 June 2026.Abstract figure legend Exacerbated ATP signalling in the carotid body (CB) of spontaneously hypertensive rats (SHRs) arises from expansion of the chemosensory glomus cell compartment and reduced extracellular ATP metabolism, leading to increased purinergic drive.
Igor S. A. Felippe +11 more
wiley +1 more source
Intracellular Cysteine 346 Is Essentially Involved in Regulating Panx1 Channel Activity [PDF]
Journal of Biological Chemistry, 2010 Pannexins constitute a family of proteins exhibiting predominantly hemichannel activity. Pannexin channels have been suggested to participate in a wide spectrum of biological functions such as propagation of calcium waves, release of IL-1β, and responses to ischemic conditions.
Stefanie, Bunse +4 more
openaire +2 more sources
The Ant1 / panx1 pathway sensitizes patients with NAFLD to lifestyle interventions [PDF]
, 2022 Abstract Background: Different patients have different sensitivities to lifestyle interventions (LSI) and thus different outcomes (improved or unchanged). In the present study, we aim to find key markers that can identify patients sensitive to lifestyle interventions.
Bo Sun +3 more
openaire +1 more source
Promises and pitfalls of a Pannexin1 transgenic mouse line.
Frontiers in Pharmacology, 2013 Gene targeting strategies have become a powerful technology for elucidating mammalian gene function. The recently generated knockout (KO)-first strategy produces a knockout at the RNA processing level and also allows for the generation of conditional KO ...
Regina eHanstein +7 more
doaj +1 more source
Frontiers in Immunology, 2019 Mast cells (MCs) release pro-inflammatory mediators through a process called degranulation response. The latter may be induced by several conditions, including antigen recognition through immunoglobulin E (IgE) or “cross-linking,” classically associated ...
Paloma A. Harcha +11 more
doaj +1 more source
Clinical and Translational Medicine, 2022 Sepsis remains the most lethal infectious disease and substantially impairs patient prognosis after liver transplantation (LT). Our previous study reported a role of the pannexin 1 (PANX1)–interleukin‐33 (IL‐33) axis in activating innate immunity to ...
Pusen Wang +10 more
doaj +1 more source
Behavioral dysfunctions of Panx1−/− mice.
, 2012 a, Pre-pulse inhibition of the acoustic startle response (PPI) showing a tendency towards lower levels in Panx1−/− (n = 8) compared to Panx1+/+ (n = 6) mice at the intensities of 62 and 64 dB.
Stefan Kurtenbach (108906) +10 more
core +1 more source
Advanced Science, Volume 13, Issue 28, 18 May 2026.Cell‐sized high‐frequency ultrasound using a lithium niobate transducer, previously ignored in reactive oxygen species (ROS) production, generated intracellular ROS at frequencies higher than conventionally used. The intracellular generation of ROS by cell‐sized high‐frequency ultrasound revealed in this study is expected to be applied to innovative ...
Kotaro Fujishiro +4 more
wiley +1 more source