Results 71 to 80 of about 3,413 (197)

Analysis of P2X7 Receptor and Panx1 Expression in Osteoporosis

, 2019
Objectives: Osteoporosis, characterized by bone mineral density decrease, leads to a high risk of bone fracture. It is now widely recognized that purinergic signaling plays an important role in the regulation of bone remodeling [ref:1]. One receptor subtype, P2X receptor is considered to be[for full text, please go to the a.m. URL]
Tang, M, Kauschke, V, El Khassawna, T, Heiß, C, Lips, K   +4 more
openaire   +2 more sources

Blocking Pannexin 1 Channels Alleviates Peripheral Inflammatory Pain but not Paclitaxel-Induced Neuropathy

Journal of Integrative Neuroscience
Background: Pannexin1 (Panx1) is a membrane channel expressed in different cells of the nervous system and is involved in several pathological conditions, including pain and inflammation.
Julia Borges Paes Lemes, Kaue Franco Malange, Nathalia Santos Carvalho, Amanda Ferreira Neves, Marcia Urban-Maldonado, Paula Regina Gelinski Kempe, Catarine Massucato Nishijima, Cecilia Costa Fagundes, Celina Monteiro da Cruz Lotufo, Sylvia Ottile Suadicani, Carlos Amilcar Parada   +10 more
doaj   +1 more source

Pannexin 1 channels: new actors in the regulation of catecholamine release from adrenal chromaffin cells

Frontiers in Cellular Neuroscience, 2014
Chromaffin cells of the adrenal gland medulla synthesize and store hormones and peptides, which are released into the blood circulation in response to stress. Among them, adrenaline is critical for the fight-or-flight response.
Fanny eMomboisse, María José Olivares, Ximena eBáez-Matus, María José Guerra, Carolina eFlores-Muñoz, Juan C. Sáez, Agustin D. Martinez, Ana M. Cárdenas   +7 more
doaj   +1 more source

Neutrophil Extracellular Traps in Wound Healing of Diabetes: Mechanisms, Inducers, and Therapeutic Implications

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Wound healing damage, especially diabetic foot ulcer (DFU), is a serious complication of diabetes mellitus (DM). New evidence shows that neutrophil extracellular traps (NETs) are the key factor of this pathology. This review summarizes the literature from 2015 to 2024 to clarify the mechanism of NETs and its harmful effects on diabetes wounds.
Jiaojiao Xue, Zeyu Wang, Wenxiu Qi, Yao Luo   +3 more
wiley   +1 more source

Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes

Molecular Metabolism, 2015
Objective: Defective glucose uptake in adipocytes leads to impaired metabolic homeostasis and insulin resistance, hallmarks of type 2 diabetes. Extracellular ATP-derived nucleotides and nucleosides are important regulators of adipocyte function, but the ...
Samantha E. Adamson, Akshaya K. Meher, Yu-hsin Chiu, Joanna K. Sandilos, Nathaniel P. Oberholtzer, Natalie N. Walker, Stefan R. Hargett, Scott A. Seaman, Shayn M. Peirce-Cottler, Brant E. Isakson, Coleen A. McNamara, Susanna R. Keller, Thurl E. Harris, Douglas A. Bayliss, Norbert Leitinger   +14 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels

British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Jörg Striessnig, Alasdair J. Gibb, Alistair A. Mathie, Emma L. Veale, Eamonn Kelly, Chloe J. Peach, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, David J. Beech, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Han Chow Chua, Alex C. Conner, Henry Danahay, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Wei Fang, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, George K. Chandy, Mohammad‐Reza Ghovanloo, Steve A. N. Goldstein, Martin Gosling, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Tim G. Hales, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Rian W. Manville, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Pérez‐Reyes, Leigh D. Plant, Stephan A. Pless, Lachlan D. Rash, Dejian Ren, Hussein N. Rubaiy, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Paolo Tammaro, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Paola Vergani, Joris Vriens, Stephen G. Waxman, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +86 more
wiley   +1 more source

Astrocyte and Neuronal Pannexin1 Contribute Distinctly to Seizures

ASN Neuro, 2019
ATP- and adenosine-mediated signaling are prominent types of glia–glia and glia–neuron interaction, with an imbalance of ATP/adenosine ratio leading to altered states of excitability, as seen in epileptic seizures.
Eliana Scemes, Libor Velíšek, Jana Velíšková   +2 more
doaj   +1 more source

Panx1^-/- dams lactate and deliver milk to pups.

, 2016
(A) Evaluation of pup body weights from 1–20 day old pups revealed significant differences between Panx1-/- mice at only a few ages (D6, D16 and D20) compared to Panx1+/+ mice (N = 30–50 pups). ***p≤0.001. (B) Litters from 10 Panx1-/- dams were evaluated
Dale W. Laird (591712), Silvia Penuela (2622640), Michael K. G. Stewart (591711), Isabelle Plante (59556)   +3 more
core   +1 more source

Mesenchymal Stromal Cells Play an Analgesic Role Through a Npy2r Sensory Neuron‐Mediated Lung‐to‐Brain Axis

Advanced Science, Volume 12, Issue 43, November 20, 2025.
Mesenchymal stromal cells (MSC) are considered a promising alternative for neuropathic pain (NP) treatment, but underlying mechanisms remain elusive. Huang et al. illustrate that a Npy2r sensory neuron‐related lung–brain axis contributes to MSC analgesia.
Jing Huang, Taihe Zhou, Yueming Sun, Yuanchen Ma, Yiwen Deng, Keyu Chen, Ruijie Li, Yuan Qiu, Tao Wang, Xiaoyong Chen, Li Huang, Lu Zhu, Xueyi Tu, Ying Wang, Zheming Liu, Rouchen Lin, Yunli Tong, Yuantao Li, Heshe Li, Lin Nie, Rui Fang, Jianqi Feng, Xuhong Wei, Xia Feng, Andy Peng Xiang, Xiaoran Zhang   +25 more
wiley   +1 more source

PANX1 hexamers work but cells prefer heptamers

Journal of General Physiology
Gupta et al. (https://doi.org/10.1085/jgp.202413676) reconcile a disconnect between structural and functional data regarding stoichiometry of PANX1 channels and provide new insights about channel activation.
openaire   +2 more sources