Results 71 to 80 of about 3,650 (196)
Glia, Volume 74, Issue 7, July 2026.Astrocytes are key sensors and transducers of biomechanical stimuli within the central nervous system. Astrocyte development is highly dependent on mechanical stimuli such as surrounding tissue stiffness and biomechanical strain. Mechanosensory pathways including integrins, connexins and pannexins, and mechanosensitive channels regulate astrocyte ...
Ana N. Strat +3 more
wiley +1 more source
Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes
Molecular Metabolism, 2015 Objective: Defective glucose uptake in adipocytes leads to impaired metabolic homeostasis and insulin resistance, hallmarks of type 2 diabetes. Extracellular ATP-derived nucleotides and nucleosides are important regulators of adipocyte function, but the ...
Samantha E. Adamson +14 more
doaj +1 more source
The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 7, July 2026.ABSTRACT Radiotherapy effectively eradicates tumor cells but can also trigger pyroptotic damage in vascular endothelial cells. This study investigates the role of interferon regulatory factor 1 (IRF1) in radiation‐induced endothelial injury, aiming to provide mechanistic insights for optimizing radiotherapy.
Chen Li +4 more
wiley +1 more source
When can AlphaFold predict the oligomeric states of proteins?
Protein Science, Volume 35, Issue 7, July 2026.Abstract Homooligomerisation is a prevalent and important process that many proteins undergo to form the quaternary structures required for biological function. However, determining oligomeric states and structures experimentally remains technically challenging and time‐consuming for many proteins.
Yiechang Lin, Ciara Wallis, Ben Corry
wiley +1 more source
Upregulation of metabotropic glutamate receptor 4 in Panx1−/− mice.
, 2012 a, Volcano plot representing the expression of 84 genes relevant for synaptic plasticity (Panx1+/+/Panx1−/−, n = 4). b, Inhibition of grm4 by bath application of 100 µM UBP1112. Fifteen minutes post-HFS, UBP1112 induced impaired persistent LTP in Panx1−/−
Stefan Kurtenbach (108906) +10 more
core +1 more source
Frontiers in Cellular Neuroscience, 2014 Chromaffin cells of the adrenal gland medulla synthesize and store hormones and peptides, which are released into the blood circulation in response to stress. Among them, adrenaline is critical for the fight-or-flight response.
Fanny eMomboisse +7 more
doaj +1 more source
The Journal of Physiology, Volume 604, Issue 14, Page 6196-6224, 15 July 2026.Abstract figure legend When the carotid body (CB) detects low oxygen levels (hypoxia), this leads to: (1) depolarization of the chemosensory cells (glomus cells) within the CB – the resulting increase in intracellular Ca2+ stimulates the exocytotic co‐release of vesicles containing ATP and glutamate; (2) synaptic ATP acts on postsynaptic petrosal ...
Olivia M. S. Gold +4 more
wiley +1 more source
Astrocyte and Neuronal Pannexin1 Contribute Distinctly to Seizures
ASN Neuro, 2019 ATP- and adenosine-mediated signaling are prominent types of glia–glia and glia–neuron interaction, with an imbalance of ATP/adenosine ratio leading to altered states of excitability, as seen in epileptic seizures.
Eliana Scemes +2 more
doaj +1 more source
Health Science Reports, Volume 9, Issue 6, June 2026.ABSTRACT Background and Aims Extracellular vesicles (EVs) are nanoscale carriers, including exosomes, microvesicles, and apoptotic bodies, that mediate intercellular communication by transporting proteins, nucleic acids, lipids, and metabolites. They regulate immunity, tissue repair, and cell differentiation.
Kajal Kamra +7 more
wiley +1 more source
Panx1-/- dams lactate and deliver milk to pups.
, 2016 (A) Evaluation of pup body weights from 1–20 day old pups revealed significant differences between Panx1-/- mice at only a few ages (D6, D16 and D20) compared to Panx1+/+ mice (N = 30–50 pups). ***p≤0.001. (B) Litters from 10 Panx1-/- dams were evaluated
Dale W. Laird (591712) +3 more
core +1 more source