Results 81 to 90 of about 3,413 (197)
PIEZO Force Sensing in Vascular Biology: An Explosion of New Knowledge, Concepts and Opportunity
Advanced Science, Volume 12, Issue 41, November 6, 2025.Knowledge of the remarkable mechanical force sensing and electrically transducing PIEZO1 and PIEZO2 channels is discussed across vascular biology and its cell types from the embryonic to adult stages in health, disease and old age. How the channels work, relate to other factors and signal for tissue responses to mechanical forces is debated.
David J Beech
wiley +1 more source
Image_2_A Potential Compensatory Role of Panx3 in the VNO of a Panx1 Knock Out Mouse Model.JPEG
, 2018 Pannexins (Panx) are integral membrane proteins, with Panx1 being the best-characterized member of the protein family. Panx1 is implicated in sensory processing, and knockout (KO) animal models have become the primary tool to investigate the role(s) of ...
Stefan Kurtenbach (108906) +5 more
core +1 more source
Unlike full-length mouse Panx1, Panx1 truncated at amino acid 379 (Δ379) is constitutively active.
, 2014 (A) HEK293T cells transfected with Δ379, full-length (FL) Panx1, or pCDNA3.1 vector alone (mock) were assayed for Yo-Pro influx (example images shown). Scale bars are 100 µm. (B) Time-lapse fluorescence microscopy was used to collect images of the Yo-Pro
David H. Hackos (574892) +2 more
core +1 more source
Revisiting the Genetics of Hypophosphatasia
Journal of Inherited Metabolic Disease, Volume 48, Issue 6, November 2025.Overview of the genetic concepts in hypophosphatasia reviewed in this manuscript. ABSTRACT Hypophosphatasia (HPP) is a rare, inherited monogenic disorder that is typically caused by variants in the tissue‐nonspecific alkaline phosphatase (ALPL) gene.
Priya S. Kishnani +8 more
wiley +1 more source
Macrophage Efferocytosis as a Therapeutic Strategy in Intervertebral Disc Degeneration
Cell Proliferation, Volume 58, Issue 10, October 2025.Macrophages, integral to degenerated intervertebral discs, play a critical role in disc degeneration. By performing efferocytosis, they clear apoptotic cells. This article explores the process of efferocytosis, its molecular mechanisms, potential therapeutic implications for intervertebral disc degeneration and future strategies for targeted treatments.
Shijie Chen +9 more
wiley +1 more source
Stomatin did not alter total or cell surface expression of Panx1.
, 2013 The amount of total and surface Panx1 protein levels were determined with transfected HEK-293 cells expressing either Myc-tagged Panx1 (Panx1::Myc) alone or Panx1::Myc plus HA-tagged stomatin (Stomatin::HA). The bar graphs show the densities of the Panx1:
Zhao-Wen Wang (317498) +9 more
core +1 more source
Ferroptosis in Cancer and Inflammatory Diseases: Mechanisms and Therapeutic Implications
MedComm, Volume 6, Issue 9, September 2025.Ferroptosis, a form of cell death driven by iron and lipid peroxidation, serves as a bridge between cancer and inflammatory diseases. Microenvironmental factors such as oxidative stress collectively regulate this process. In cancer, ferroptosis exhibits dual roles: while it eliminates drug‐resistant cells, it may also promote tumor metastasis.
Guangyi Shen +4 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2018 Neurite formation relies on finely-tuned control of the cytoskeleton. Here we identified a novel protein-protein interaction between the ion and metabolite channel protein Pannexin 1 (Panx1) and collapsin response mediator protein 2 (Crmp2), a positive ...
Xiaoxue Xu +9 more
doaj +1 more source
Image_1_A Potential Compensatory Role of Panx3 in the VNO of a Panx1 Knock Out Mouse Model.JPEG
, 2018 Pannexins (Panx) are integral membrane proteins, with Panx1 being the best-characterized member of the protein family. Panx1 is implicated in sensory processing, and knockout (KO) animal models have become the primary tool to investigate the role(s) of ...
Stefan Kurtenbach (108906) +5 more
core +1 more source
Image_6_A Potential Compensatory Role of Panx3 in the VNO of a Panx1 Knock Out Mouse Model.jpg
, 2018 Pannexins (Panx) are integral membrane proteins, with Panx1 being the best-characterized member of the protein family. Panx1 is implicated in sensory processing, and knockout (KO) animal models have become the primary tool to investigate the role(s) of ...
Stefan Kurtenbach (108906) +5 more
core +1 more source