Results 81 to 90 of about 2,772 (166)

The ATP-exporting channel Pannexin 1 promotes CD8+ T cell effector and memory responses

iScience
Summary: Sensing of extracellular ATP (eATP) controls CD8+ T cell function. Their accumulation can occur through export by specialized molecules, such as the release channel Pannexin 1 (Panx1). Whether Panx1 controls CD8+ T cell immune responses in vivo,
Trupti Vardam-Kaur, Alma Banuelos, Maria Gabaldon-Parish, Bruna Gois Macedo, Caio Loureiro Salgado, Kelsey Marie Wanhainen, Maggie Hanqi Zhou, Sarah van Dijk, Igor Santiago-Carvalho, Angad S. Beniwal, Chloe L. Leff, Changwei Peng, Nhan L. Tran, Stephen C. Jameson, Henrique Borges da Silva   +14 more
doaj   +1 more source

Human pannexin 1 channel is not phosphorylated by Src tyrosine kinase at Tyr199 and Tyr309

eLife
Protein phosphorylation is one of the major molecular mechanisms regulating protein activity and function throughout the cell. Pannexin 1 (PANX1) is a large-pore channel permeable to ATP and other cellular metabolites.
Zheng Ruan, Junuk Lee, Yangyang Li, Juan Du, Wei Lü   +4 more
doaj   +1 more source

The C-terminal activating domain promotes Panx1 channel opening

ABSTRACT Pannexin 1 (Panx1) constitutes a large pore channel responsible for the release of ATP from apoptotic cells. Strong evidence indicates that caspase-mediated cleavage of the C-terminus promotes the opening of the Panx1 channel by unplugging the pore.
Erik Henze, Jacqueline J. Ehrlich, Janice L. Robertson, Toshimitsu Kawate   +3 more
openaire   +2 more sources

Cold Exposure Rejuvenates the Metabolic Phenotype of Panx1−/− Mice

Biomolecules
Pannexin1 (Panx1) ATP channels are important in adipocyte biology, potentially influencing energy storage and expenditure. We compared the metabolic phenotype of young (14 weeks old) and mature (20 weeks old) wild-type (WT) and Panx1−/− mice exposed or not to cold (6 °C) during 28 days, a condition promoting adipocyte browning.
Molica, Filippo, Ehrlich, Avigail, Pelli, Graziano, Rusiecka, Olga, Montessuit, Christophe Albert, Chanson, Marc, Kwak, Brenda   +6 more
openaire   +4 more sources

Global pannexin 1 deletion increases tumor‐infiltrating lymphocytes in the BRAF/Pten mouse melanoma model

Molecular Oncology
Immunotherapies for malignant melanoma seek to boost the anti‐tumoral response of CD8+ T cells, but have a limited patient response rate, in part due to limited tumoral immune cell infiltration.
Rafael E. Sanchez‐Pupo, Garth A. Finch, Danielle E. Johnston, Heather Craig, Rober Abdo, Kevin Barr, Steven Kerfoot, Lina Dagnino, Silvia Penuela   +8 more
doaj   +1 more source

A novel heterozygous missense variant of PANX1 causes human oocyte death and female infertility

Journal of Ovarian Research
Pannexin1 (PANX1) is a highly glycosylated membrane channel-forming protein, which has been found to implicate in multiple physiological and pathophysiological functions.
Juepu Zhou, Ruolin Mao, Meng Wang, Rui Long, Limin Gao, Xiangfei Wang, Lei Jin, Lixia Zhu   +7 more
doaj   +1 more source

Microglial Panx1 is a Spinal Determinant of Arthritis Joint Pain

, 2018
Pain is a debilitating feature of arthritis. Despite recent advances in treating joint inflammation and the widespread use of pain medications by arthritis patients, adequate pain control is an ongoing medical problem. A major challenge is that joint pain is poorly understood: some individuals with severe joint damage report little pain, whereas ...
openaire   +2 more sources

Activation of Pannexin-1 channels causes cell dysfunction and damage in mesangial cells derived from angiotensin II-exposed mice

Frontiers in Cell and Developmental Biology
Chronic kidney disease (CKD) is a prevalent health concern associated with various pathological conditions, including hypertensive nephropathy. Mesangial cells are crucial in maintaining glomerular function, yet their involvement in CKD pathogenesis ...
Claudia M. Lucero, Laura Navarro, Cristián Barros-Osorio, Patricio Cáceres-Conejeros, Juan A. Orellana, Gonzalo I. Gómez   +5 more
doaj   +1 more source

PANX1-mediated ATP release confers FAM3A’s suppression effects on hepatic gluconeogenesis and lipogenesis

Military Medical Research
Background Extracellular adenosine triphosphate (ATP) is an important signal molecule. In previous studies, intensive research had revealed the crucial roles of family with sequence similarity 3 member A (FAM3A) in controlling hepatic glucolipid ...
Cheng-Qing Hu, Tao Hou, Rui Xiang, Xin Li, Jing Li, Tian-Tian Wang, Wen-Jun Liu, Song Hou, Di Wang, Qing-He Zhao, Xiao-Xing Yu, Ming Xu, Xing-Kai Liu, Yu-Jing Chi, Ji-Chun Yang   +14 more
doaj   +1 more source

Pannexin 1 (PANX1) [PDF]

Science-Business eXchange, 2014
openaire   +1 more source