Results 81 to 90 of about 3,650 (196)

PANX1 hexamers work but cells prefer heptamers

Journal of General Physiology
Gupta et al. (https://doi.org/10.1085/jgp.202413676) reconcile a disconnect between structural and functional data regarding stoichiometry of PANX1 channels and provide new insights about channel activation.
openaire   +2 more sources

Cardiomyocyte PANX1 Controls Glycolysis and Neutrophil Recruitment in Hypertrophy

Circulation Research
BACKGROUND: PANX1 (pannexin 1), a ubiquitously expressed ATP release membrane channel, has been shown to play a role in inflammation, blood pressure regulation, and myocardial infarction. However, the possible role of PANX1 in cardiomyocytes in the progression of heart failure has not yet been investigated.
Caitlin M. Pavelec, Alexander P. Young, Hannah L. Luviano, Emily E. Orrell, Anna Szagdaj, Nabin Poudel, Abigail G. Wolpe, Samantha H. Thomas, Scott Yeudall, Clint M. Upchurch, Mark D. Okusa, Brant E. Isakson, Matthew J. Wolf, Norbert Leitinger   +13 more
openaire   +2 more sources

Blocking Pannexin 1 Channels Alleviates Peripheral Inflammatory Pain but not Paclitaxel-Induced Neuropathy

Journal of Integrative Neuroscience
Background: Pannexin1 (Panx1) is a membrane channel expressed in different cells of the nervous system and is involved in several pathological conditions, including pain and inflammation.
Julia Borges Paes Lemes, Kaue Franco Malange, Nathalia Santos Carvalho, Amanda Ferreira Neves, Marcia Urban-Maldonado, Paula Regina Gelinski Kempe, Catarine Massucato Nishijima, Cecilia Costa Fagundes, Celina Monteiro da Cruz Lotufo, Sylvia Ottile Suadicani, Carlos Amilcar Parada   +10 more
doaj   +1 more source

Periodontitis as a Model for Inflammatory Uncoupling of Bone Remodeling

Journal of Periodontal Research, Volume 61, Issue 6, Page 662-694, June 2026.
Periodontitis can be viewed as a state of inflammatory uncoupling of bone remodeling, in which excessive osteoclast‐mediated resorption coexists with impaired bone formation. This review integrates emerging insights from osteoimmunology, osteocyte biology, mechanobiology, aging, and resolution pathways to position periodontitis as an accessible in vivo
Rafael Scaf de Molon, Sotirios Tetradis, Rolando Vernal, Fabio Renato Manzolli Leite, Thomas E. Van Dyke   +4 more
wiley   +1 more source

Exacerbated ATP transmission in the carotid body is linked to glomus cell expansion in spontaneously hypertensive rats

The Journal of Physiology, Volume 604, Issue 12, Page 4678-4706, 15 June 2026.
Abstract figure legend Exacerbated ATP signalling in the carotid body (CB) of spontaneously hypertensive rats (SHRs) arises from expansion of the chemosensory glomus cell compartment and reduced extracellular ATP metabolism, leading to increased purinergic drive.
Igor S. A. Felippe, Audrys Pauza, Olivia M. S. Gold, Xin Shen, Fernanda Brognara, Rosanna Roberts Nonu, Dylan K. Pen, Aabharika Bose, Emma N. Bardsley, Anna P. Ponnampalam, Davi J. A. Moraes, Julian F. R. Paton   +11 more
wiley   +1 more source

Unlike full-length mouse Panx1, Panx1 truncated at amino acid 379 (Δ379) is constitutively active.

, 2014
(A) HEK293T cells transfected with Δ379, full-length (FL) Panx1, or pCDNA3.1 vector alone (mock) were assayed for Yo-Pro influx (example images shown). Scale bars are 100 µm. (B) Time-lapse fluorescence microscopy was used to collect images of the Yo-Pro
David H. Hackos (574892), Michelle Dourado (574890), Evera Wong (574891)   +2 more
core   +1 more source

Image_2_A Potential Compensatory Role of Panx3 in the VNO of a Panx1 Knock Out Mouse Model.JPEG

, 2018
Pannexins (Panx) are integral membrane proteins, with Panx1 being the best-characterized member of the protein family. Panx1 is implicated in sensory processing, and knockout (KO) animal models have become the primary tool to investigate the role(s) of ...
Stefan Kurtenbach (108906), Peter L. Carlen (503661), Georg Zoidl (90612), Christiane Zoidl (475818), Paige Whyte-Fagundes (5145230), Valery I. Shestopalov (108914)   +5 more
core   +1 more source

Intracellular Reactive Oxygen Species Generation Induced by High‐Frequency Ultrasound in Thickness Vibration Mode

Advanced Science, Volume 13, Issue 28, 18 May 2026.
Cell‐sized high‐frequency ultrasound using a lithium niobate transducer, previously ignored in reactive oxygen species (ROS) production, generated intracellular ROS at frequencies higher than conventionally used. The intracellular generation of ROS by cell‐sized high‐frequency ultrasound revealed in this study is expected to be applied to innovative ...
Kotaro Fujishiro, Satoshi Okada, Filippo Rossi, Takahiro Kuchimaru, Yuta Kurashina   +4 more
wiley   +1 more source

Panx1^-/- mice have normal mammary glands at parturition.

, 2016
(A) Evaluation of body weight, mammary gland weight and normalized mammary gland weight revealed that Panx1-/- mice were similar to control mice at parturition. (B) Whole mount analysis revealed numerous alveoli filling the mammary fat pad.
Dale W. Laird (591712), Silvia Penuela (2622640), Michael K. G. Stewart (591711), Isabelle Plante (59556)   +3 more
core   +1 more source

Probenecid Disrupts a Novel Pannexin 1-Collapsin Response Mediator Protein 2 Interaction and Increases Microtubule Stability

Frontiers in Cellular Neuroscience, 2018
Neurite formation relies on finely-tuned control of the cytoskeleton. Here we identified a novel protein-protein interaction between the ion and metabolite channel protein Pannexin 1 (Panx1) and collapsin response mediator protein 2 (Crmp2), a positive ...
Xiaoxue Xu, Leigh E. Wicki-Stordeur, Juan C. Sanchez-Arias, Mei Liu, Mei Liu, Maria S. Weaver, Catherine S. W. Choi, Leigh A. Swayne, Leigh A. Swayne, Leigh A. Swayne   +9 more
doaj   +1 more source