Results 91 to 100 of about 2,772 (166)

Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage

Biological Research
Abstract Background Alcohol, a widely abused drug, significantly diminishes life quality, causing chronic diseases and psychiatric issues, with severe health, societal, and economic repercussions. Previously, we demonstrated that non-voluntary alcohol consumption increases the opening of Cx43 hemichannels and Panx1 ...
Gonzalo I. Gómez, Tanhia F. Alvear, Daniela A. Roa, Arantza Farias-Pasten, Sergio A. Vergara, Luis A. Mellado, Claudio J. Martinez-Araya, Juan Prieto-Villalobos, Claudia García-Rodríguez, Natalia Sánchez, Juan C. Sáez, Fernando C. Ortíz, Juan A. Orellana   +12 more
openaire   +4 more sources

NMDAR-mediated activation of pannexin1 channels contributes to the detonator properties of hippocampal mossy fiber synapses

iScience
Summary: Pannexins are large-pore ion channels expressed throughout the mammalian brain that participate in various neuropathologies; however, their physiological roles remain obscure.
Cinthia Rangel-Sandoval, Marisol Soula, Wei-Ping Li, Pablo E. Castillo, David L. Hunt   +4 more
doaj   +1 more source

The small molecule raptinal can simultaneously induce apoptosis and inhibit PANX1 activity

Cell Death & Disease
AbstractDiscovery of new small molecules that can activate distinct programmed cell death pathway is of significant interest as a research tool and for the development of novel therapeutics for pathological conditions such as cancer and infectious diseases.
Jascinta P. Santavanond, Yu-Hsin Chiu, Rochelle Tixeira, Zonghan Liu, Jeremy K. Y. Yap, Kaiwen W. Chen, Chen-Lu Li, Yi-Ru Lu, Joan Roncero-Carol, Esteban Hoijman, Stephanie F. Rutter, Bo Shi, Gemma F. Ryan, Amy L. Hodge, Sarah Caruso, Amy A. Baxter, Dilara C. Ozkocak, Chad Johnson, Zoe I. Day, Alyce J. Mayfosh, Mark D. Hulett, Thanh K. Phan, Georgia K. Atkin-Smith, Ivan K. H. Poon   +23 more
openaire   +8 more sources

Reduced Serum Pannexin-1 Levels in Obstructive Sleep Apnea and Their Association with Nocturnal Hypoxemic Burden. [PDF]

J Clin Med
Canlı ET, Öztürk Ö, Türkmen Kaya H, Şirin FB, Gümüşcan D, Aydın T, Karaibrahimoğlu A.   +6 more
europepmc   +1 more source

Cardiovascular Characterization of Cx40/Panx1 Single and Double Knockout Mice [PDF]

, 2016
Connexins (Cxs) and pannexins (Panxs) are protein families that form large-pore channels which exist at the plasma membrane for both intracellular and extracellular signaling. Given their potential for overlapping cellular signaling functions we proposed that mice lacking both a connexin and a pannexin would have a severe phenotype. To investigate this
openaire  

Pannexin-1-mediated ATP signaling as a driver of immune communication and chronic inflammation in HIV infection. [PDF]

Front Immunol
Kaufman EK, Swartz TH.
europepmc   +1 more source

Panx1 and P2X7R are associated with impaired skeletal health and delayed bone development in early onset of type 1 diabetes. [PDF]

Front Endocrinol (Lausanne)
Seref-Ferlengez Z, Urban-Maldonado M, Uyar A, Thent ZC, Tun A, Saw BP, Schaffler MB, Suadicani SO, Thi MM.   +8 more
europepmc   +1 more source

Abnormal elevated PANX1 expression hampers endometrial decidualization by upregulating extracellular ATP concentration in patients with recurrent implantation failure. [PDF]

Sci Rep
Liu XL, Yang Q, Liu PP, Cao LY, Li X, Zhang ZQ, Sun XE, Tan J, Cheng Y.   +8 more
europepmc   +1 more source

Panx1 deficiency exacerbates GAN diet-induced obesity by destabilizing β-catenin via GSK3β. [PDF]

iScience
Xu H, Zhao J, Lu S, Wang Q, Sun R, Gao Y, Xie F, Wang Y, Cao R, Feng Y, Liu X, Kou B, Chai M, Li B, Yu X, Zhang J, Zhang Y.   +16 more
europepmc   +1 more source

Connexin 43 and Pannexin 1 in Renal Cell Populations in Diabetic Kidney Disease. [PDF]

Int J Mol Sci
Jelinčić Korčulanin M, Racetin A, Pavlović N, Jeličić I, Glavina Durdov M, Andrzejewska M, Jerčić L, Bočina I, Kević N, Restović I, Vukojević K, Bajt P, Svaguša K, Filipović N.   +13 more
europepmc   +1 more source