Results 111 to 120 of about 3,413 (197)
The C-terminal activating domain promotes Panx1 channel opening
ABSTRACT Pannexin 1 (Panx1) constitutes a large pore channel responsible for the release of ATP from apoptotic cells. Strong evidence indicates that caspase-mediated cleavage of the C-terminus promotes the opening of the Panx1 channel by unplugging the pore.
Erik Henze +3 more
openaire +2 more sources
A novel heterozygous missense variant of PANX1 causes human oocyte death and female infertility
Journal of Ovarian ResearchPannexin1 (PANX1) is a highly glycosylated membrane channel-forming protein, which has been found to implicate in multiple physiological and pathophysiological functions.
Juepu Zhou +7 more
doaj +1 more source
C Blue No. 1 is a selective inhibitor of the ATP release channel Panx1
, 2013 The food dye FD&C Blue No. 1 (Brilliant Blue FCF [BB FCF]) is structurally similar to the purinergic receptor antagonist Brilliant Blue G (BBG), which is a well-known inhibitor of the ionotropic P2X7 receptor (P2X7R).
Dahl, Gerhard +5 more
core +1 more source
Military Medical ResearchBackground Extracellular adenosine triphosphate (ATP) is an important signal molecule. In previous studies, intensive research had revealed the crucial roles of family with sequence similarity 3 member A (FAM3A) in controlling hepatic glucolipid ...
Cheng-Qing Hu +14 more
doaj +1 more source
Frontiers in Cell and Developmental BiologyChronic kidney disease (CKD) is a prevalent health concern associated with various pathological conditions, including hypertensive nephropathy. Mesangial cells are crucial in maintaining glomerular function, yet their involvement in CKD pathogenesis ...
Claudia M. Lucero +5 more
doaj +1 more source
A metastasis‐associated pannexin‐1 mutant (Panx1 1‐89 ) forms a minimalist ATP release channel
A truncated form of the ATP release channel pannexin 1 (Panx1), Panx1 1–89 , is enriched in metastatic breast cancer cells and has been proposed to mediate metastatic cell survival by increasing ATP release through mechanosensitive Panx1 channels ...
Dahl, Gerhard +5 more
core +1 more source
Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway
, 2017 Red blood cell (RBC)-derived adenosine triphosphate (ATP) has been proposed as an integral component in the regulation of oxygen supply to skeletal muscle.
Edwin Kerry Jackson +10 more
core +1 more source
Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage
Biological ResearchAbstract Background Alcohol, a widely abused drug, significantly diminishes life quality, causing chronic diseases and psychiatric issues, with severe health, societal, and economic repercussions. Previously, we demonstrated that non-voluntary alcohol consumption increases the opening of Cx43 hemichannels and Panx1 ...
Gonzalo I. Gómez +12 more
openaire +4 more sources
Protective effect of Panx1 KO in ischemic retina.
, 2012 A. Representative micrographs of retinas from experimental (post-IR) and control sham treated (sham) eyes from WT, Panx1 CKO (CKO) and Panx1 KO (KO) animals challenged by retinal IR.
Vladlen Z. Slepak (113409) +6 more
core +1 more source