Results 111 to 120 of about 3,650 (196)
Image_1_A Potential Compensatory Role of Panx3 in the VNO of a Panx1 Knock Out Mouse Model.JPEG
, 2018 Pannexins (Panx) are integral membrane proteins, with Panx1 being the best-characterized member of the protein family. Panx1 is implicated in sensory processing, and knockout (KO) animal models have become the primary tool to investigate the role(s) of ...
Stefan Kurtenbach (108906) +5 more
core +1 more source
Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway
, 2017 Red blood cell (RBC)-derived adenosine triphosphate (ATP) has been proposed as an integral component in the regulation of oxygen supply to skeletal muscle.
Edwin Kerry Jackson +10 more
core +1 more source
A novel heterozygous missense variant of PANX1 causes human oocyte death and female infertility
Journal of Ovarian ResearchPannexin1 (PANX1) is a highly glycosylated membrane channel-forming protein, which has been found to implicate in multiple physiological and pathophysiological functions.
Juepu Zhou +7 more
doaj +1 more source
A metastasis‐associated pannexin‐1 mutant (Panx1 1‐89 ) forms a minimalist ATP release channel
A truncated form of the ATP release channel pannexin 1 (Panx1), Panx1 1–89 , is enriched in metastatic breast cancer cells and has been proposed to mediate metastatic cell survival by increasing ATP release through mechanosensitive Panx1 channels ...
Dahl, Gerhard +5 more
core +1 more source
C Blue No. 1 is a selective inhibitor of the ATP release channel Panx1
, 2013 The food dye FD&C Blue No. 1 (Brilliant Blue FCF [BB FCF]) is structurally similar to the purinergic receptor antagonist Brilliant Blue G (BBG), which is a well-known inhibitor of the ionotropic P2X7 receptor (P2X7R).
Dahl, Gerhard +5 more
core +1 more source
Microglial Panx1 is a Spinal Determinant of Arthritis Joint Pain
, 2018 Pain is a debilitating feature of arthritis. Despite recent advances in treating joint inflammation and the widespread use of pain medications by arthritis patients, adequate pain control is an ongoing medical problem. A major challenge is that joint pain is poorly understood: some individuals with severe joint damage report little pain, whereas ...
openaire +2 more sources
Military Medical ResearchBackground Extracellular adenosine triphosphate (ATP) is an important signal molecule. In previous studies, intensive research had revealed the crucial roles of family with sequence similarity 3 member A (FAM3A) in controlling hepatic glucolipid ...
Cheng-Qing Hu +14 more
doaj +1 more source
Frontiers in Cell and Developmental BiologyChronic kidney disease (CKD) is a prevalent health concern associated with various pathological conditions, including hypertensive nephropathy. Mesangial cells are crucial in maintaining glomerular function, yet their involvement in CKD pathogenesis ...
Claudia M. Lucero +5 more
doaj +1 more source
Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage
Biological ResearchAbstract Background Alcohol, a widely abused drug, significantly diminishes life quality, causing chronic diseases and psychiatric issues, with severe health, societal, and economic repercussions. Previously, we demonstrated that non-voluntary alcohol consumption increases the opening of Cx43 hemichannels and Panx1 ...
Gonzalo I. Gómez +12 more
openaire +4 more sources