Results 121 to 130 of about 3,413 (197)

Deficient IL-1β release from activated Panx1 KO splenic macrophages.

, 2013
Bar histograms showing the mean ± s.e.m. values of interleukin-1β (IL-1β) measured from media bathing Panx1 wild type (WT) and Panx1 knockout (KO) macrophage cultures that were untreated, treated with lipopolysaccharide (LPS) and treated with LPS and ...
Sylvia O. Suadicani (424633), Leonid Tarassishin (326809), Juan Carlos Chara Ventura (424630), Naman K. Patel (204869), Sarah E. Lutz (204871), Hiromitsu Negoro (424632), Sunhee C. Lee (326811), Carlos Matute (201313), Eliana Scemes (204874), Estibaliz González-Fernández (424629), Alberto Pérez-Samartín (424631)   +10 more
core   +1 more source

The small molecule raptinal can simultaneously induce apoptosis and inhibit PANX1 activity

Cell Death & Disease
AbstractDiscovery of new small molecules that can activate distinct programmed cell death pathway is of significant interest as a research tool and for the development of novel therapeutics for pathological conditions such as cancer and infectious diseases.
Jascinta P. Santavanond, Yu-Hsin Chiu, Rochelle Tixeira, Zonghan Liu, Jeremy K. Y. Yap, Kaiwen W. Chen, Chen-Lu Li, Yi-Ru Lu, Joan Roncero-Carol, Esteban Hoijman, Stephanie F. Rutter, Bo Shi, Gemma F. Ryan, Amy L. Hodge, Sarah Caruso, Amy A. Baxter, Dilara C. Ozkocak, Chad Johnson, Zoe I. Day, Alyce J. Mayfosh, Mark D. Hulett, Thanh K. Phan, Georgia K. Atkin-Smith, Ivan K. H. Poon   +23 more
openaire   +8 more sources

NMDAR-mediated activation of pannexin1 channels contributes to the detonator properties of hippocampal mossy fiber synapses

iScience
Summary: Pannexins are large-pore ion channels expressed throughout the mammalian brain that participate in various neuropathologies; however, their physiological roles remain obscure.
Cinthia Rangel-Sandoval, Marisol Soula, Wei-Ping Li, Pablo E. Castillo, David L. Hunt   +4 more
doaj   +1 more source

Distinct Roles of Astrocyte and Neuronal Panx1 in Kainic Acid-Induced Seizures and Related Behavioral Deficits

, 2022
Epileptic seizures result from central nervous system (CNS) hyperexcitation due to imbalances in excitatory and inhibitory signaling. Purinergic signals mediated by extracellular adenosine triphosphate (ATP) can exacerbate seizures by augmenting CNS ...
Obot, Price
core  

Additional file 1 of Neuronal Panx1 drives peripheral sensitization in experimental plantar inflammatory pain

Additional file 1: Table S1 Primer pairs for qRT-PCR. Fig. S1 Detailed pain threshold analysis in WT, global Panx1 KO, NFH-Cre, and GFAP-Cre Panx1 KO mice after CFA inflammation. Fig.
Preeti Dohare (17655559), Greta Luyuan Yang (8628687), David C. Spray (294210), Qing-Hua Li (1633066), Antonio Cibelli (8847641), Eliana Scemes (204874), Qu Xing (18464472), Fang-Xia Guan (18464475)   +7 more
core   +1 more source

Reduced Serum Pannexin-1 Levels in Obstructive Sleep Apnea and Their Association with Nocturnal Hypoxemic Burden. [PDF]

J Clin Med
Canlı ET, Öztürk Ö, Türkmen Kaya H, Şirin FB, Gümüşcan D, Aydın T, Karaibrahimoğlu A.   +6 more
europepmc   +1 more source

Pannexin-1-mediated ATP signaling as a driver of immune communication and chronic inflammation in HIV infection. [PDF]

Front Immunol
Kaufman EK, Swartz TH.
europepmc   +1 more source

Cardiovascular Characterization of Cx40/Panx1 Single and Double Knockout Mice [PDF]

, 2016
Connexins (Cxs) and pannexins (Panxs) are protein families that form large-pore channels which exist at the plasma membrane for both intracellular and extracellular signaling. Given their potential for overlapping cellular signaling functions we proposed that mice lacking both a connexin and a pannexin would have a severe phenotype. To investigate this
openaire  

Panx1 and P2X7R are associated with impaired skeletal health and delayed bone development in early onset of type 1 diabetes. [PDF]

Front Endocrinol (Lausanne)
Seref-Ferlengez Z, Urban-Maldonado M, Uyar A, Thent ZC, Tun A, Saw BP, Schaffler MB, Suadicani SO, Thi MM.   +8 more
europepmc   +1 more source

Role of panx1 in bone marrow-derived macrophages and possible links to atherosclerosis

, 2017
Aim: Atherosclerosis is a major cardiovascular disease and the principal cause of death worldwide. It is a progressive disease of the medium-sized and large arties characterized by a dysfunctional endothelium, an accumulation of lipids and an abnormal ...
Ehrlich, Avigail
core