Results 101 to 110 of about 3,413 (197)

Virgin Panx1^-/- mice have normal mammary glands.

, 2016
(A) Evaluation of body weights at 4 and 7 weeks revealed that pre-pubertal Panx1-/- mice were significantly larger at 4 weeks compared to control mice. Values are mean body weights ± S.E.M. * P -/- compared to Panx1+/+ mice. Values are mean weights ± S.E.
Dale W. Laird (591712), Silvia Penuela (2622640), Michael K. G. Stewart (591711), Isabelle Plante (59556)   +3 more
core   +1 more source

Panx1^-/- mice have normal mammary glands at parturition.

, 2016
(A) Evaluation of body weight, mammary gland weight and normalized mammary gland weight revealed that Panx1-/- mice were similar to control mice at parturition. (B) Whole mount analysis revealed numerous alveoli filling the mammary fat pad.
Dale W. Laird (591712), Silvia Penuela (2622640), Michael K. G. Stewart (591711), Isabelle Plante (59556)   +3 more
core   +1 more source

Involuting Panx1^-/- mouse mammary glands have normal gland regression.

, 2016
(A) Evaluation of body weight, mammary gland weight and normalized mammary gland weight revealed no significant difference between in Panx1-/- mice compared to control mice.
Dale W. Laird (591712), Silvia Penuela (2622640), Michael K. G. Stewart (591711), Isabelle Plante (59556)   +3 more
core   +1 more source

The ATP-exporting channel Pannexin 1 promotes CD8+ T cell effector and memory responses

iScience
Summary: Sensing of extracellular ATP (eATP) controls CD8+ T cell function. Their accumulation can occur through export by specialized molecules, such as the release channel Pannexin 1 (Panx1). Whether Panx1 controls CD8+ T cell immune responses in vivo,
Trupti Vardam-Kaur, Alma Banuelos, Maria Gabaldon-Parish, Bruna Gois Macedo, Caio Loureiro Salgado, Kelsey Marie Wanhainen, Maggie Hanqi Zhou, Sarah van Dijk, Igor Santiago-Carvalho, Angad S. Beniwal, Chloe L. Leff, Changwei Peng, Nhan L. Tran, Stephen C. Jameson, Henrique Borges da Silva   +14 more
doaj   +1 more source

Stomatin and Panx1 were both enriched in the plasma membrane region.

, 2013
Myc-tagged Panx1 (Panx1::Myc) and HA-tagged stomatin (Stomatin::HA) were coexpressed in HEK-293 cells. Panx1 and stomatin were visualized by double immunostaining with antibodies to Myc and HA, respectively. Shown are representative images of Panx1::Myc (
Zhao-Wen Wang (317498), Haiying Zhan (317485), Xin Zhou (54275), Bojun Chen (317487), Stephen J. Crocker (317497), Michael V. L. Bennett (317494), Xue-Jun Li (244909), Xin-Ming Ma (317489), Craig S. Moore (317486), Kumiko Ijichi (317491)   +9 more
core   +1 more source

Cold Exposure Rejuvenates the Metabolic Phenotype of Panx1−/− Mice

Biomolecules
Pannexin1 (Panx1) ATP channels are important in adipocyte biology, potentially influencing energy storage and expenditure. We compared the metabolic phenotype of young (14 weeks old) and mature (20 weeks old) wild-type (WT) and Panx1−/− mice exposed or not to cold (6 °C) during 28 days, a condition promoting adipocyte browning.
Molica, Filippo, Ehrlich, Avigail, Pelli, Graziano, Rusiecka, Olga, Montessuit, Christophe Albert, Chanson, Marc, Kwak, Brenda   +6 more
openaire   +4 more sources

Human pannexin 1 channel is not phosphorylated by Src tyrosine kinase at Tyr199 and Tyr309

eLife
Protein phosphorylation is one of the major molecular mechanisms regulating protein activity and function throughout the cell. Pannexin 1 (PANX1) is a large-pore channel permeable to ATP and other cellular metabolites.
Zheng Ruan, Junuk Lee, Yangyang Li, Juan Du, Wei Lü   +4 more
doaj   +1 more source

Microglial Panx1 is a Spinal Determinant of Arthritis Joint Pain

, 2018
Pain is a debilitating feature of arthritis. Despite recent advances in treating joint inflammation and the widespread use of pain medications by arthritis patients, adequate pain control is an ongoing medical problem. A major challenge is that joint pain is poorly understood: some individuals with severe joint damage report little pain, whereas ...
openaire   +2 more sources

Global pannexin 1 deletion increases tumor‐infiltrating lymphocytes in the BRAF/Pten mouse melanoma model

Molecular Oncology
Immunotherapies for malignant melanoma seek to boost the anti‐tumoral response of CD8+ T cells, but have a limited patient response rate, in part due to limited tumoral immune cell infiltration.
Rafael E. Sanchez‐Pupo, Garth A. Finch, Danielle E. Johnston, Heather Craig, Rober Abdo, Kevin Barr, Steven Kerfoot, Lina Dagnino, Silvia Penuela   +8 more
doaj   +1 more source

Loss of Panx1 alters postsynaptic responses in the hippocampal CA1 area.

, 2012
a, IO-relations demonstrate increased excitability of acute Panx1−/− hippocampal slices (−/−, solid line; +/+, dashed line). b, fEPSP sample traces at 10, 50, 100% of the maximum input stimulus intensity.
Stefan Kurtenbach (108906), Nora Prochnow (4627), Georg Zoidl (90612), Julian Hanske (108912), Galina Dvoriantchikova (108911), Elisabeth Petrasch-Parwez (69110), Denise Manahan-Vaughan (84573), Verena Wildförster (108909), Valery I. Shestopalov (108914), Rolf Dermietzel (90615), Amr Abdulazim (108903)   +10 more
core   +1 more source