Results 101 to 110 of about 3,650 (196)
Emerging functions of Pannexin 1 in the eye
Frontiers in Cellular Neuroscience, 2014 Pannexin 1 (Panx1) is a high-conductance, voltage-gated channel protein found in vertebrates. It has been shown that Panx1 is widely expressed in many organs and tissues, including sensory systems.
Sarah eKurtenbach +2 more
doaj +1 more source
Stomatin and Panx1 were both enriched in the plasma membrane region.
, 2013 Myc-tagged Panx1 (Panx1::Myc) and HA-tagged stomatin (Stomatin::HA) were coexpressed in HEK-293 cells. Panx1 and stomatin were visualized by double immunostaining with antibodies to Myc and HA, respectively. Shown are representative images of Panx1::Myc (
Zhao-Wen Wang (317498) +9 more
core +1 more source
Image_5_A Potential Compensatory Role of Panx3 in the VNO of a Panx1 Knock Out Mouse Model.jpg
, 2018 Pannexins (Panx) are integral membrane proteins, with Panx1 being the best-characterized member of the protein family. Panx1 is implicated in sensory processing, and knockout (KO) animal models have become the primary tool to investigate the role(s) of ...
Stefan Kurtenbach (108906) +5 more
core +1 more source
Loss of Panx1 alters postsynaptic responses in the hippocampal CA1 area.
, 2012 a, IO-relations demonstrate increased excitability of acute Panx1−/− hippocampal slices (−/−, solid line; +/+, dashed line). b, fEPSP sample traces at 10, 50, 100% of the maximum input stimulus intensity.
Stefan Kurtenbach (108906) +10 more
core +1 more source
The C-terminal activating domain promotes Panx1 channel opening
ABSTRACT Pannexin 1 (Panx1) constitutes a large pore channel responsible for the release of ATP from apoptotic cells. Strong evidence indicates that caspase-mediated cleavage of the C-terminus promotes the opening of the Panx1 channel by unplugging the pore.
Erik Henze +3 more
openaire +2 more sources
The ATP-exporting channel Pannexin 1 promotes CD8+ T cell effector and memory responses
iScienceSummary: Sensing of extracellular ATP (eATP) controls CD8+ T cell function. Their accumulation can occur through export by specialized molecules, such as the release channel Pannexin 1 (Panx1). Whether Panx1 controls CD8+ T cell immune responses in vivo,
Trupti Vardam-Kaur +14 more
doaj +1 more source
Image_6_A Potential Compensatory Role of Panx3 in the VNO of a Panx1 Knock Out Mouse Model.jpg
, 2018 Pannexins (Panx) are integral membrane proteins, with Panx1 being the best-characterized member of the protein family. Panx1 is implicated in sensory processing, and knockout (KO) animal models have become the primary tool to investigate the role(s) of ...
Stefan Kurtenbach (108906) +5 more
core +1 more source
Cold Exposure Rejuvenates the Metabolic Phenotype of Panx1−/− Mice
BiomoleculesPannexin1 (Panx1) ATP channels are important in adipocyte biology, potentially influencing energy storage and expenditure. We compared the metabolic phenotype of young (14 weeks old) and mature (20 weeks old) wild-type (WT) and Panx1−/− mice exposed or not to cold (6 °C) during 28 days, a condition promoting adipocyte browning.
Molica, Filippo +6 more
openaire +4 more sources
Molecular OncologyImmunotherapies for malignant melanoma seek to boost the anti‐tumoral response of CD8+ T cells, but have a limited patient response rate, in part due to limited tumoral immune cell infiltration.
Rafael E. Sanchez‐Pupo +8 more
doaj +1 more source
Human pannexin 1 channel is not phosphorylated by Src tyrosine kinase at Tyr199 and Tyr309
eLifeProtein phosphorylation is one of the major molecular mechanisms regulating protein activity and function throughout the cell. Pannexin 1 (PANX1) is a large-pore channel permeable to ATP and other cellular metabolites.
Zheng Ruan +4 more
doaj +1 more source