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Proximal tubule pannexin 1 contributes to mitochondrial dysfunction and cell death during acute kidney injury. [PDF]
Am J Physiol Renal PhysiolPoudel N +14 more
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Cx43 Hemichannel and Panx1 Channel Modulation by Gap19 and 10Panx1 Peptides
International Journal of Molecular Sciences, 2023 Cx43 hemichannels (HCs) and Panx1 channels are two genetically distant protein families. Despite the lack of sequence homology, Cx43 and Panx1 channels have been the subject of debate due to their overlapping expression and the fact that both channels present similarities in terms of their membrane topology and electrical properties.
Luc Leybaert +2 more
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A novel heterozygous variant in PANX1 is associated with oocyte death and female infertility
Journal of Assisted Reproduction and Genetics, 2022Oocyte death is a severe clinical phenotype that causes female infertility and recurrent in vitro fertilization and intracytoplasmic sperm injection failure. We aimed to identify pathogenic variants in a female infertility patient with oocyte death phenotype.Sanger sequencing was performed to screen PANX1 variants in the affected patient.
Jun Tan
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Double deletion of Panx1 and Panx3 affects skin and bone but not hearing
Journal of Molecular Medicine, 2019 Pannexins (Panxs), large-pore channel forming glycoproteins, are expressed in a wide variety of tissues including the skin, bone, and cochlea. To date, the use of single knock-out mouse models of both Panx1 and Panx3 have demonstrated their roles in skin development, bone formation, and auditory phenotypes.
Silvia Peñuela
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Destination and consequences of Panx1 and mutant expression in polarized MDCK cells
Experimental Cell Research, 2019The channel-forming membrane glycoprotein pannexin 1 (Panx1) is best characterized as an ATP release channel. To investigate the trafficking and sorting of Panx1, we used polarized MDCK cells and non-polarized BICR-M1Rk cells to track the fate of GFP-tagged Panx1.
Qing Shao +2 more
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Homozygous variants in PANX1 cause human oocyte death and female infertility
European Journal of Human Genetics, 2021PANX1, one of the members of the pannexin family, is a highly glycosylated channel-forming protein. Recently, we identified heterozygous variants in PANX1 that follow an autosomal dominant inheritance pattern and cause female infertility characterized by oocyte death. In this study, we screened for novel PANX1 variants in patients with the phenotype of
Shujia Zhu, Li Jin, Ronggui Qu
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Sleep-wake cycle and experimental models of Panx1 mutations
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2018To test the hypothesis of a possible role of the Panx1 (pannexin-1) mutation in changing the sleep - wake cycle.Continuous 24 h recording of the EEG and movement activity in Panx1 knockout and wild type mice was performed.A significant increase in wake percentage at the expense of a decrease in slow-wave sleep was found in knockout mice as compared to ...
V M, Kovalzon +3 more
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Spreading Depression Triggers Headache by Activating Neuronal Panx1 Channels
Science, 2013How Migraine Develops Migraine is a common medical disorder. Unfortunately, how and why migraine headache is initiated is unclear. Karatas et al. (p. 1092 ) now describe
Hulya, Karatas +6 more
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[Distribution and regulation of Panx1 protein].
Sheng li ke xue jin zhan [Progress in physiology], 2014Pannexin1 (Panx1) is a subtype of the newly discovered gap junction proteins named Pannexin(s). Panx1 is widely expressed in the nervous system, cardiovascular system, etc and can form non-selective and large conductance hemichannel. It has been demonstrated that various conditions can regulate Panx1 open and affect the body's physiological function ...
Xiang-Xing, Kong +3 more
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