Results 61 to 70 of about 2,772 (166)
Health Science Reports, Volume 9, Issue 6, June 2026.ABSTRACT Background and Aims Extracellular vesicles (EVs) are nanoscale carriers, including exosomes, microvesicles, and apoptotic bodies, that mediate intercellular communication by transporting proteins, nucleic acids, lipids, and metabolites. They regulate immunity, tissue repair, and cell differentiation.
Kajal Kamra +7 more
wiley +1 more source
The Journal of Physiology, Volume 604, Issue 12, Page 4678-4706, 15 June 2026.Abstract figure legend Exacerbated ATP signalling in the carotid body (CB) of spontaneously hypertensive rats (SHRs) arises from expansion of the chemosensory glomus cell compartment and reduced extracellular ATP metabolism, leading to increased purinergic drive.
Igor S. A. Felippe +11 more
wiley +1 more source
Analysis of P2X7 Receptor and Panx1 Expression in Osteoporosis
, 2019 Objectives: Osteoporosis, characterized by bone mineral density decrease, leads to a high risk of bone fracture. It is now widely recognized that purinergic signaling plays an important role in the regulation of bone remodeling [ref:1]. One receptor subtype, P2X receptor is considered to be[for full text, please go to the a.m. URL]
Tang, M +4 more
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Frontiers in Cellular Neuroscience, 2014 Chromaffin cells of the adrenal gland medulla synthesize and store hormones and peptides, which are released into the blood circulation in response to stress. Among them, adrenaline is critical for the fight-or-flight response.
Fanny eMomboisse +7 more
doaj +1 more source
Advanced Science, Volume 13, Issue 28, 18 May 2026.Cell‐sized high‐frequency ultrasound using a lithium niobate transducer, previously ignored in reactive oxygen species (ROS) production, generated intracellular ROS at frequencies higher than conventionally used. The intracellular generation of ROS by cell‐sized high‐frequency ultrasound revealed in this study is expected to be applied to innovative ...
Kotaro Fujishiro +4 more
wiley +1 more source
Journal of Integrative NeuroscienceBackground: Pannexin1 (Panx1) is a membrane channel expressed in different cells of the nervous system and is involved in several pathological conditions, including pain and inflammation.
Julia Borges Paes Lemes +10 more
doaj +1 more source
Journal of Cellular Physiology, Volume 241, Issue 5, May 2026.The immunometabolite itaconate modulates the connexin profile of neural stem cells, and it upregulates Cx36‐based channels, promoting the differentiation toward a neuronal phenotype. These effects were abolished by connexin blockade, supporting a role for itaconate in the neuroimmune axis in inflammatory and neurodegenerative disorders. ABSTRACT Neural
Simona Denaro +8 more
wiley +1 more source
Cardiomyocyte PANX1 Controls Glycolysis and Neutrophil Recruitment in Hypertrophy
Circulation ResearchBACKGROUND: PANX1 (pannexin 1), a ubiquitously expressed ATP release membrane channel, has been shown to play a role in inflammation, blood pressure regulation, and myocardial infarction. However, the possible role of PANX1 in cardiomyocytes in the progression of heart failure has not yet been investigated.
Caitlin M. Pavelec +13 more
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Astrocyte and Neuronal Pannexin1 Contribute Distinctly to Seizures
ASN Neuro, 2019 ATP- and adenosine-mediated signaling are prominent types of glia–glia and glia–neuron interaction, with an imbalance of ATP/adenosine ratio leading to altered states of excitability, as seen in epileptic seizures.
Eliana Scemes +2 more
doaj +1 more source
PANX1 hexamers work but cells prefer heptamers
Journal of General PhysiologyGupta et al. (https://doi.org/10.1085/jgp.202413676) reconcile a disconnect between structural and functional data regarding stoichiometry of PANX1 channels and provide new insights about channel activation.
openaire +2 more sources