Results 61 to 70 of about 3,413 (197)

Connexin Regulation and Modulation of Neural Stem Cell Differentiation Induced by Cell‐Permeable Itaconate

Journal of Cellular Physiology, Volume 241, Issue 5, May 2026.
The immunometabolite itaconate modulates the connexin profile of neural stem cells, and it upregulates Cx36‐based channels, promoting the differentiation toward a neuronal phenotype. These effects were abolished by connexin blockade, supporting a role for itaconate in the neuroimmune axis in inflammatory and neurodegenerative disorders. ABSTRACT Neural
Simona Denaro, Simona Rosa Spina, Simona D'Aprile, Anna Gervasi, Filippo Torrisi, Carmela Parenti, Agata Zappalà, Nunzio Vicario, Rosalba Parenti   +8 more
wiley   +1 more source

Overlap in synaptic neurological condition susceptibility pathways and the neural pannexin 1 interactome revealed by bioinformatics analyses

Channels, 2023
Many neurological conditions exhibit synaptic impairments, suggesting mechanistic convergence. Additionally, the pannexin 1 (PANX1) channel and signaling scaffold is linked to several of these neurological conditions and is an emerging regulator of ...
Simona D Frederiksen, Leigh E Wicki-Stordeur, Leigh Anne Swayne   +2 more
doaj   +1 more source

Pre- and postsynaptic components of altered Panx1^−/− LTP.

, 2012
a, Evoked LTP in presence of 3 µM adenosine: Panx1−/− derived fEPSPs during early and persistent LTP phases are restored towards LTP levels of the untreated controls.
Stefan Kurtenbach (108906), Nora Prochnow (4627), Georg Zoidl (90612), Julian Hanske (108912), Galina Dvoriantchikova (108911), Elisabeth Petrasch-Parwez (69110), Denise Manahan-Vaughan (84573), Verena Wildförster (108909), Valery I. Shestopalov (108914), Rolf Dermietzel (90615), Amr Abdulazim (108903)   +10 more
core   +1 more source

Sequences of mouse and wildtype human Panx1 and variants.

, 2023
(A) Comparison between amino acid sequences of mouse and human pannexin proteins. In red are amino acids found in human Panx1 that differ from those found in mouse. (B).
Preeti Dohare (17655559), David C. Spray (294210), Antonio Cibelli (8847641), Eliana Scemes (204874)   +3 more
core   +1 more source

Astrocytes as central integrators of neural circuit function: Mechanisms and dysregulation in neuropsychiatric disorders

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
1. Astrocytes are central integrators of neural circuit function through tripartite synapse modulation and neurovascular coupling. 2. Dysregulation of glutamate/GABA homeostasis and neuroinflammation represents shared mechanisms across diverse neuropsychiatric disorders. 3.
Xinyu Liu, Xinyue Zhou, Ruotong Meng, Yanxi Chen, You Chen, Blake Highet, Maurice Curtis, Bernhard Hirt, Shunying Yu, Jin Zhou, Linya You   +10 more
wiley   +1 more source

Inhibition of PANX1 Channels Reduces the Malignant Properties of Human High-Risk Neuroblastoma

Journal of Cancer, 2023
Pannexin 1 (PANX1) is expressed in many tissue types including tissues of neural origin. Neuroblastoma (NB) is a neural crest-derived malignancy mainly occurring in children. The majority of NB patients present with high-risk disease for which current therapies are ineffective. Here, we show that while PANX1 is expressed in NB of all stages, high PANX1
Langlois, Stéphanie, St-Pierre, Marie-Eve, Holland, Stephen H., Xiang, Xiao, Freeman, Emily, Mohamed, Hisham, Dural, Ahmet Cem, Hammad, Ahmed, Karami, Sanaz, van de Panne, Chloé, Cowan, Kyle N.   +10 more
openaire   +2 more sources

Pannexin 1 dysregulation in Duchenne muscular dystrophy and its exacerbation of dystrophic features in mdx mice

Skeletal Muscle
Background Duchenne muscular dystrophy (DMD) is associated with impaired muscle regeneration, progressive muscle weakness, damage, and wasting. While the cause of DMD is an X-linked loss of function mutation in the gene encoding dystrophin, the exact ...
Emily Freeman, Stéphanie Langlois, Marcos F. Leyba, Tarek Ammar, Zacharie Léger, Hugh J. McMillan, Jean-Marc Renaud, Bernard J. Jasmin, Kyle N. Cowan   +8 more
doaj   +1 more source

Targeting inflammation in cardiometabolic disease: Icosapent ethyl modulates monocyte‐derived macrophages isolated from patients with cardiovascular disease with or without type 2 diabetes

Diabetic Medicine, Volume 43, Issue 4, April 2026.
Abstract Aims Despite intensive lipid‐lowering therapy, individuals with atherosclerotic cardiovascular disease (ASCVD) exhibit residual inflammatory risk, which drives recurrent cardiovascular events. This risk is amplified in type 2 diabetes mellitus (T2DM), where a pro‐inflammatory milieu accelerates atherogenesis. Monocyte‐derived macrophages (MDMs)
J. K. Ward, M. U. Shah, K. Lee, P. E. Squires, C. E. Hills   +4 more
wiley   +1 more source

Upregulation of metabotropic glutamate receptor 4 in Panx1^−/− mice.

, 2012
a, Volcano plot representing the expression of 84 genes relevant for synaptic plasticity (Panx1+/+/Panx1−/−, n = 4). b, Inhibition of grm4 by bath application of 100 µM UBP1112. Fifteen minutes post-HFS, UBP1112 induced impaired persistent LTP in Panx1−/−
Stefan Kurtenbach (108906), Nora Prochnow (4627), Georg Zoidl (90612), Julian Hanske (108912), Galina Dvoriantchikova (108911), Elisabeth Petrasch-Parwez (69110), Denise Manahan-Vaughan (84573), Verena Wildförster (108909), Valery I. Shestopalov (108914), Rolf Dermietzel (90615), Amr Abdulazim (108903)   +10 more
core   +1 more source

Metabolic reprogramming of efferocytosis in the tumour microenvironment: From apoptotic‐cell clearance to therapeutic targeting

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
This review systematically deconstructs the pathological efferocytic—metabolic axis in tumours, framing it as a three‐stage, self‐reinforcing cycle: from metabolite‐driven macrophage recruitment, through hijacked surface recognition, to post‐phagocytic metabolic reprogramming that locks in immunosuppression.
Qianlu Yang, Jie Yan, Qianxi Yang
wiley   +1 more source