Results 61 to 70 of about 3,650 (196)
Behavioral dysfunctions of Panx1−/− mice.
, 2012 a, Pre-pulse inhibition of the acoustic startle response (PPI) showing a tendency towards lower levels in Panx1−/− (n = 8) compared to Panx1+/+ (n = 6) mice at the intensities of 62 and 64 dB.
Stefan Kurtenbach (108906) +10 more
core +1 more source
Analysis of P2X7 Receptor and Panx1 Expression in Osteoporosis
, 2019 Objectives: Osteoporosis, characterized by bone mineral density decrease, leads to a high risk of bone fracture. It is now widely recognized that purinergic signaling plays an important role in the regulation of bone remodeling [ref:1]. One receptor subtype, P2X receptor is considered to be[for full text, please go to the a.m. URL]
Tang, M +4 more
openaire +2 more sources
Clinical and Translational Medicine, 2022 Sepsis remains the most lethal infectious disease and substantially impairs patient prognosis after liver transplantation (LT). Our previous study reported a role of the pannexin 1 (PANX1)–interleukin‐33 (IL‐33) axis in activating innate immunity to ...
Pusen Wang +10 more
doaj +1 more source
Channels, 2023 Many neurological conditions exhibit synaptic impairments, suggesting mechanistic convergence. Additionally, the pannexin 1 (PANX1) channel and signaling scaffold is linked to several of these neurological conditions and is an emerging regulator of ...
Simona D Frederiksen +2 more
doaj +1 more source
Migraine: Epidemiology, Risk Factors, Pathophysiology, and Treatment
MedComm, Volume 7, Issue 9, September 2026.Migraine is a highly prevalent, female‐predominant, and disabling brain disorder shaped by genetic susceptibility, hormonal influences, modifiable attack factors, and comorbidity‐related progression. This review integrates current evidence on migraine epidemiology, phase‐specific neurovascular and neuroglial mechanisms, including CGRP signaling and ...
Weiwei Lu +9 more
wiley +1 more source
Advanced Science, Volume 13, Issue 44, 7 August 2026.ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen +7 more
wiley +1 more source
Skeletal MuscleBackground Duchenne muscular dystrophy (DMD) is associated with impaired muscle regeneration, progressive muscle weakness, damage, and wasting. While the cause of DMD is an X-linked loss of function mutation in the gene encoding dystrophin, the exact ...
Emily Freeman +8 more
doaj +1 more source
Journal of Clinical Laboratory Analysis, Volume 40, Issue 15, August 2026.Clinical utility of trio WGS and time metrics in a neonate with congenital anomalies and hemolytic anemia. ABSTRACT Background Neonates with complex and evolving phenotypes often lack sufficiently specific clinical features to guide targeted genetic testing.
Hyun‐Woo Lee +8 more
wiley +1 more source
Pre- and postsynaptic components of altered Panx1−/− LTP.
, 2012 a, Evoked LTP in presence of 3 µM adenosine: Panx1−/− derived fEPSPs during early and persistent LTP phases are restored towards LTP levels of the untreated controls.
Stefan Kurtenbach (108906) +10 more
core +1 more source
Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.Stress‐induced switch. Under stress conditions, small extracellular vesicle release shifts from the constitutive ‘torn bag mechanism’ to exocytosis of multivesicular endosomes. https://BioRender.com/xn1pa1e. ABSTRACT The biogenesis of small extracellular vesicles (sEVs) is only partially understood.
Dorina Lenzinger +18 more
wiley +1 more source