Results 51 to 60 of about 7,051 (198)

Astrocytic connexin43 phosphorylation contributes to seizure susceptibility after mild traumatic brain injury

The FEBS Journal, EarlyView.
Astrocytic gap junctions formed by connexin43 (Cx43) help maintain brain homeostasis. After mild traumatic brain injury (TBI), total cortical Cx43 increases and redistributes toward a soluble, non‐junctional pool with elevated hemichannel activity and increased phosphorylation at serine 368 (pCx43S368).
Carmen Muñoz‐Ballester, Owen Leitzel, Samantha Golf, Chelsea M. Phillips, Michael J. Zeitz, Rahul Pandit, Elizabeth Wash, Jenna V. Donohue, Elizabeth A. Istre, James W. Smyth, Samy Lamouille, Stefanie Robel   +11 more
wiley   +1 more source

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

The role of pannexin hemichannels in inflammation and regeneration [PDF]

Frontiers in Physiology, 2014
Tissue injury involves coordinated systemic responses including inflammatory response, targeted cell migration, cell-cell communication, stem cell activation and proliferation, and tissue inflammation and regeneration. The inflammatory response is an important prerequisite for regeneration.
Helen P. Makarenkova, Valery I. Shestopalov, Valery I. Shestopalov   +2 more
openaire   +3 more sources

Serum levels of neurotensin, pannexin-1, and sestrin-2 and the correlations with sleep quality or/and cognitive function in the patients with chronic insomnia disorder

Frontiers in Psychiatry
ObjectivesTo examine serum concentrations of neurotensin, pannexin-1 and sestrin-2, and their correlations with subjective and objective sleep quality and cognitive function in the patients with chronic insomnia disorder (CID).MethodsSixty-five CID ...
Ai-Xi Su, Ai-Xi Su, Zi-Jie Ma, Zong-Yin Li, Xue-Yan Li, Lan Xia, Yi-Jun Ge, Gui-Hai Chen   +7 more
doaj   +1 more source

Loci nominally associated with autism from genome-wide analysis show enrichment of brain expression quantitative trait loci but not lymphoblastoid cell line expression quantitative trait loci

Molecular Autism, 2012
Background Autism spectrum disorder is a severe early onset neurodevelopmental disorder with high heritability but significant heterogeneity. Traditional genome-wide approaches to test for an association of common variants with autism susceptibility risk
Davis Lea K, Gamazon Eric R, Kistner-Griffin Emily, Badner Judith A, Liu Chunyu, Cook Edwin H, Sutcliffe James S, Cox Nancy J   +7 more
doaj   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents [PDF]

, 2017
The release of ATP from spinal microglia via pannexin-1 channels is required for withdrawal symptoms after termination of chronic opioid treatment in rodents, and pharmacological blockade of pannexin-1 channels reduces the severity of withdrawal without ...
Burma, Nicole E, Baimel, Corey, Bonin, Robert P, De Koninck, Yves, Patrick L Stemkowski, Baimoukhametova, Dinara, Corey Baimel, Gerald W Zamponi, Mousseau, Michael, Yves De Koninck, Jaideep S Bains, Heather Leduc-Pessah, Antle, Michael C, Stephanie L Borgland, DeKoninck, Yves, Jhenkruthi Vijaya Shankara, Michael C Antle, Zoe F Cairncross, Shankara, Jhenkruthi Vijaya, Yves DeKoninck, Tuan Trang, Nicole E Burma, Borgland, Stephanie L, Robert P Bonin, Michael Mousseau, Trang, Tuan, Cairncross, Zoe F, Cahill, Catherine M, Catherine M Cahill, Stemkowski, Patrick L, Bains, Jaideep S, Dinara Baimoukhametova, Leduc-Pessah, Heather, Zamponi, Gerald W   +33 more
core   +1 more source

Connexin43- and Pannexin-Based Channels in Neuroinflammation and Cerebral Neuropathies

Frontiers in Molecular Neuroscience, 2017
Connexins (Cx) are largely represented in the central nervous system (CNS) with 11 Cx isoforms forming intercellular channels. Moreover, in the CNS, Cx43 can form hemichannels (HCs) at non-junctional membrane as does the related channel-forming Pannexin1
Denis Sarrouilhe, Catherine Dejean, Marc Mesnil   +2 more
doaj   +1 more source

Immune cells in the pathogenesis of abdominal aortic aneurysm: Roles, regulation and targeted interventions

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review provides a comprehensive overview of how macrophages, neutrophils, T cells and other immune cells infiltrate the aortic wall, undergo phenotypic shifts and interact with one another in abdominal aortic aneurysm (AAA). Background Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease with no approved clinical drugs. Immune
Junqi Peng, Hanqing Zhang, Yun Wu, Song Chen   +3 more
wiley   +1 more source

Differential profiles of pannexin-1 in diabetes and wound healing during aging [PDF]

, 2023
Diabetes mellitus is a very common disease with a global prevalence of 470 million in 2017. Diabetics have a higher risk of developing a number of complications in the cornea including dysfunctional wound healing, many of which currently have risky or ...
Machen, Cody
core   +1 more source