Cryo-EM structures of pannexin 1 and 3 reveal differences among pannexin isoforms [PDF]
Nature CommunicationsPannexins are single-membrane large-pore channels that release ions and ATP upon activation. Three isoforms of pannexins 1, 2, and 3, perform diverse cellular roles and differ in their pore lining residues.
Nazia Hussain +7 more
doaj +3 more sources
HIF-Regulated Pannexin-1 Channel Drives Luminal ATP Accumulation in Kidney Cysts. [PDF]
FASEB JAutosomal dominant polycystic kidney disease causes progressive cyst enlargement in the kidneys, leading to hypoxia and induction of HIF‐1α. Our study identifies HIF‐1α‐dependent transcriptional upregulation of Pannexin1 (PANX1) in the apical membrane of cyst epithelial cells, promoting ATP release into the cyst lumen.
Skoczynski K +10 more
europepmc +2 more sources
Pannexin 1 targets mitophagy to mediate renal ischemia/reperfusion injury [PDF]
Communications Biology, 2023 Renal ischemia/reperfusion (I/R) injury contributes to the development of acute kidney injury (AKI). Kidney is the second organ rich in mitochondrial content next to the heart. Mitochondrial damage substantially contributes for AKI development. Mitophagy
Lianjiu Su +8 more
doaj +2 more sources
Pannexin 1 induces Rhabdomyosarcoma cell fusion by downregulating APOBEC2 [PDF]
OncogenesisRhabdomyosarcoma (RMS) is an aggressive cancer thought to arise from impaired myogenesis. This can be substantially overcome by increasing the levels of pannexin 1 (PANX1), a critical component of the myogenic program, but the mechanism involved is ...
Alexandra Welten +6 more
doaj +2 more sources
The Role of Pannexin-1 Channels in HIV and NeuroHIV Pathogenesis [PDF]
Cells, 2022 The human immunodeficiency virus-1 (HIV) enters the brain shortly after infection, leading to long-term neurological complications in half of the HIV-infected population, even in the current anti-retroviral therapy (ART) era. Despite decades of research,
Cristian A. Hernandez, Eugenin Eliseo
doaj +2 more sources
Type II Cells in the Human Carotid Body Display P2X7 Receptor and Pannexin-1 Immunoreactivity [PDF]
BiomoleculesThe carotid body is a peripheral chemoreceptor that consists of clusters of chemoreceptive type I cells, glia-like type II cells, afferent and efferent nerves, and sinusoidal capillaries and arterioles.
Marcos Anache +10 more
doaj +2 more sources
Serum levels of neurotensin, pannexin-1, and sestrin-2 and the correlations with sleep quality or/and cognitive function in the patients with chronic insomnia disorder [PDF]
Frontiers in PsychiatryObjectivesTo examine serum concentrations of neurotensin, pannexin-1 and sestrin-2, and their correlations with subjective and objective sleep quality and cognitive function in the patients with chronic insomnia disorder (CID).MethodsSixty-five CID ...
Ai-Xi Su +7 more
doaj +2 more sources
Pannexin-1 Modulates Inhibitory Transmission and Hippocampal Synaptic Plasticity [PDF]
Biomolecules, 2023 Pannexin-1 (Panx1) hemichannel is a non-selective transmembrane channel that may play important roles in intercellular signaling by allowing the permeation of ions and metabolites, such as ATP. Although recent evidence shows that the Panx1 hemichannel is
Francisca García-Rojas +6 more
doaj +2 more sources
Role of Pannexin 1, P2X7, and CFTR in ATP Release and Autocrine Signaling by Principal Cells of the Epididymis [PDF]
FunctionExtracellular adenosine triphosphate (ATP) is a signaling molecule that acts as a paracrine and autocrine modulator of cell function. Here, we characterized the role of luminal ATP in the regulation of epithelial principal cells (PCs) in the epididymis ...
Kéliane Brochu +4 more
doaj +2 more sources
Inhibition of pannexin‐1 does not restore electrolyte balance in precystic Pkd1 knockout mice [PDF]
Physiological ReportsMutations in PKD1 and PKD2 cause autosomal dominant polycystic kidney disease (ADPKD), which is characterized by the formation of fluid‐filled cysts in the kidney.
Wouter H. vanMegen +5 more
doaj +2 more sources