Results 31 to 40 of about 29,697,217 (152)

Distinct Molecular Mechanisms Underlying Potassium Efflux for NLRP3 Inflammasome Activation

Frontiers in Immunology, 2020
The NLRP3 inflammasome is a core component of innate immunity, and dysregulation of NLRP3 inflammasome involves developing autoimmune, metabolic, and neurodegenerative diseases.
Ziwei Xu, Zi-mo Chen, Xiaoyan Wu, Linjie Zhang, Ying Cao, Pingzheng Zhou   +5 more
doaj   +1 more source

Extracellular ATP hydrolysis inhibits synaptic transmission by increasing ph buffering in the synaptic cleft. [PDF]

PLoS Biology, 2014
Neuronal computations strongly depend on inhibitory interactions. One such example occurs at the first retinal synapse, where horizontal cells inhibit photoreceptors.
Rozan Vroman, Lauw J Klaassen, Marcus H C Howlett, Valentina Cenedese, Jan Klooster, Trijntje Sjoerdsma, Maarten Kamermans   +6 more
doaj   +1 more source

Taking a close look at a large-pore channel

eLife, 2020
The structure of pannexin 1, a channel protein with a large pore, has been determined for the first time.
Pablo S Gaete, Jorge E Contreras
doaj   +1 more source

Neurodegeneration in Multiple Sclerosis: The Role of Nrf2-Dependent Pathways

Antioxidants, 2022
Multiple sclerosis (MS) encompasses a chronic, irreversible, and predominantly immune-mediated disease of the central nervous system that leads to axonal degeneration, neuronal death, and several neurological symptoms.
Paloma P. Maldonado, Coram Guevara, Margrethe A. Olesen, Juan Andres Orellana, Rodrigo A. Quintanilla, Fernando C. Ortiz   +5 more
doaj   +1 more source

Roles of Pannexin-1 Channels in Inflammatory Response through the TLRs/NF-Kappa B Signaling Pathway Following Experimental Subarachnoid Hemorrhage in Rats

Frontiers in Molecular Neuroscience, 2017
Background: Accumulating evidence suggests that neuroinflammation plays a critical role in early brain injury after subarachnoid hemorrhage (SAH). Pannexin-1 channels, as a member of gap junction proteins located on the plasma membrane, releases ATP ...
Ling-Yun Wu, Zhen-Nan Ye, Chen-Hui Zhou, Chun-Xi Wang, Guang-Bin Xie, Xiang-Sheng Zhang, Yong-Yue Gao, Zi-Huan Zhang, Meng-Liang Zhou, Zong Zhuang, Jing-Peng Liu, Chun-Hua Hang, Chun-Hua Hang, Ji-Xin Shi   +13 more
doaj   +1 more source

MSCs-derived apoptotic extracellular vesicles promote muscle regeneration by inducing Pannexin 1 channel-dependent creatine release by myoblasts

International Journal of Oral Science, 2023
Severe muscle injury is hard to heal and always results in a poor prognosis. Recent studies found that extracellular vesicle-based therapy has promising prospects for regeneration medicine, however, whether extracellular vesicles have therapeutic effects
Qingyuan Ye, Xinyu Qiu, Jinjin Wang, Boya Xu, Yuting Su, Chenxi Zheng, Linyuan Gui, Lu Yu, Huijuan Kuang, Huan Liu, Xiaoning He, Zhiwei Ma, Qintao Wang, Yan Jin   +13 more
doaj   +1 more source

Emerging functions of Pannexin 1 in the eye

Frontiers in Cellular Neuroscience, 2014
Pannexin 1 (Panx1) is a high-conductance, voltage-gated channel protein found in vertebrates. It has been shown that Panx1 is widely expressed in many organs and tissues, including sensory systems.
Sarah eKurtenbach, Stefan eKurtenbach, Georg eZoidl   +2 more
doaj   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). I. Treatments in preclinical and early clinical development

Epilepsia, EarlyView.
Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Herb-partitioned moxibustion alleviates colonic inflammation in Crohn's disease rats by inhibiting hyperactivation of the NLRP3 inflammasome via regulation of the P2X7R-Pannexin-1 signaling pathway.

PLoS ONE, 2021
Crohn's disease is a chronic inflammatory bowel disease and the NLRP3 inflammasome plays an important role in Crohn's disease. Previous studies have shown that Herb-partitioned moxibustion treating (at Qihai (CV 6) and Tianshu (ST 25)) prevented the ...
Ji Zhang, Xue-Jun Wang, Li-Jie Wu, Ling Yang, Yan-Ting Yang, Dan Zhang, Jue Hong, Xi-Ying Li, Xiao-Qing Dong, Xiao-Cong Guo, Rong Han, Xiaopeng Ma   +11 more
doaj   +1 more source

Astrocytic connexin43 phosphorylation contributes to seizure susceptibility after mild traumatic brain injury

The FEBS Journal, EarlyView.
Astrocytic gap junctions formed by connexin43 (Cx43) help maintain brain homeostasis. After mild traumatic brain injury (TBI), total cortical Cx43 increases and redistributes toward a soluble, non‐junctional pool with elevated hemichannel activity and increased phosphorylation at serine 368 (pCx43S368).
Carmen Muñoz‐Ballester, Owen Leitzel, Samantha Golf, Chelsea M. Phillips, Michael J. Zeitz, Rahul Pandit, Elizabeth Wash, Jenna V. Donohue, Elizabeth A. Istre, James W. Smyth, Samy Lamouille, Stefanie Robel   +11 more
wiley   +1 more source