Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism. [PDF]
PLoS ONE, 2014 P2X7 is a ligand-gated ion channel which is activated by ATP and displays secondary permeability characteristics. The mechanism of development of the secondary permeability pathway is currently unclear, although a role for the hemichannel protein ...
Archana Bhaskaracharya +7 more
doaj +1 more source
Physiological Reports, 2023 Development of autosomal dominant polycystic kidney disease (ADPKD) involves renal epithelial cell abnormalities. Cystic fluid contains a high level of ATP that, among other effects, leads to a reduced reabsorption of electrolytes in cyst‐lining cells ...
Sergey N. Arkhipov +5 more
doaj +1 more source
P2X4 assembles with P2X7 and pannexin-1 in gingival epithelial cells and modulates ATP-induced reactive oxygen species production and inflammasome activation. [PDF]
PLoS ONE, 2013 We have previously reported that Porphyromonas gingivalis infection of gingival epithelial cells (GEC) requires an exogenous danger signal such as ATP to activate an inflammasome and caspase-1, thereby inducing secretion of interleukin (IL)-1β ...
Shu-Chen Hung +7 more
doaj +1 more source
Pannexin 1 Influences Lineage Specification of Human iPSCs
Frontiers in Cell and Developmental Biology, 2021 Every single cell in the body communicates with nearby cells to locally organize activities with their neighbors and dysfunctional cell-cell communication can be detrimental during cell lineage commitment, tissue patterning and organ development ...
Rebecca J. Noort +2 more
doaj +1 more source
Dual Regulatory Roles of Pannexin 1 in the Pathogenesis and Recovery of Sepsis-Induced Acute Lung Injury. [PDF]
Infect Drug ResistQiancheng Xu,1,* Yan Qian,2,* Yingya Cao,1 Weihua Lu,1 Jianguo Li3 1Department of Critical Care Medicine, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, Anhui, 241000, People’s
Xu Q, Qian Y, Cao Y, Lu W, Li J.
europepmc +2 more sources
Identification of Pannexins in Rat Nasal Mucosa
Allergy & Rhinology, 2013 Pannexins are a second family of gap-junction proteins in vertebrates, classified as pannexin-1, pannexin-2, and pannexin-3. Pannexin-1 is one of the candidates for channel-mediated ATP release into the extracellular space.
Toyoaki Ohbuchi M.D. +7 more
doaj +1 more source
Single-cell dynamics of pannexin-1-facilitated programmed ATP loss during apoptosis
eLife, 2020 ATP is essential for all living cells. However, how dead cells lose ATP has not been well investigated. In this study, we developed new FRET biosensors for dual imaging of intracellular ATP level and caspase-3 activity in single apoptotic cultured human ...
Hiromi Imamura +8 more
doaj +1 more source
Functional implications of calcium permeability of the channel formed by pannexin 1. [PDF]
, 2006 Although human pannexins (PanX) are homologous to gap junction molecules, their physiological function in vertebrates remains poorly understood. Our results demonstrate that overexpression of PanX1 results in the formation of Ca(2+)-permeable gap ...
Ivanov, Dmitry, V +31 more
core +1 more source
Pannexin 1 channels in skeletal muscles
Frontiers in Physiology, 2014 Normal myotubes and adult innervated skeletal myofibers express the glycoprotein pannexin1 (Panx1). Six of them form a gap junction hemichannel-like structure that connects the cytoplasm with the extracellular space; here they will be called Panx1 ...
Luis Andrés Cea +6 more
doaj +1 more source
Pannexin-1 channel regulates nuclear content packaging into apoptotic bodies and their size
, 2021 Apoptotic bodies (ApoBDs), which are large extracellular vesicles exclusively released by apoptotic cells, possess therapeutically exploitable properties including biomolecule loadability and transferability.
Ivan Poon (9481238) +7 more
core +1 more source