Knockout of Pannexin-1 Induces Hearing Loss [PDF]
International Journal of Molecular Sciences, 2018 Mutations of gap junction connexin genes induce a high incidence of nonsyndromic hearing loss. Pannexin genes also encode gap junctional proteins in vertebrates. Recent studies demonstrated that Pannexin-1 (Panx1) deficiency in mice and mutation in humans are also associated with hearing loss.
Chen, Jin +4 more
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Powerful partnership: crosstalk between pannexin 1 and the cytoskeleton [PDF]
Frontiers in Physiology, 2014 Pannexin 1 (Panx1) large-pore ion and metabolite channels are emerging as key proteins in many physiological and pathophysiological scenarios. Recent evidence has tightly linked Panx1 trafficking and function to the cytoskeleton, a multi-component ...
Andrew Kenneth Jameson Boyce +5 more
doaj +3 more sources
Role of Pannexin 1, P2X7, and CFTR in ATP Release and Autocrine Signaling by Principal Cells of the Epididymis [PDF]
FunctionExtracellular adenosine triphosphate (ATP) is a signaling molecule that acts as a paracrine and autocrine modulator of cell function. Here, we characterized the role of luminal ATP in the regulation of epithelial principal cells (PCs) in the epididymis ...
Kéliane Brochu +4 more
doaj +2 more sources
Inhibition of pannexin‐1 does not restore electrolyte balance in precystic Pkd1 knockout mice [PDF]
Physiological ReportsMutations in PKD1 and PKD2 cause autosomal dominant polycystic kidney disease (ADPKD), which is characterized by the formation of fluid‐filled cysts in the kidney.
Wouter H. vanMegen +5 more
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Probenecid, a gout remedy, inhibits pannexin 1 channels [PDF]
American Journal of Physiology-Cell Physiology, 2008 Probenecid is a well-established drug for the treatment of gout and is thought to act on an organic anion transporter, thereby affecting uric acid excretion in the kidney by blocking urate reuptake. Probenecid also has been shown to affect ATP release, leading to the suggestion that ATP release involves an organic anion transporter.
William, Silverman +2 more
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Pannexin-1 Channels as Mediators of Neuroinflammation [PDF]
International Journal of Molecular Sciences, 2021 Neuroinflammation is a major component of central nervous system (CNS) injuries and neurological diseases, including Alzheimer’s disease, multiple sclerosis, neuropathic pain, and brain trauma. The activation of innate immune cells at the damage site causes the release of pro-inflammatory cytokines and chemokines, which alter the functionality of ...
Seo, Joon Ho +2 more
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Plasma and aqueous humor levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy [PDF]
International Journal of Ophthalmology, 2022 AIM: To evaluate plasma and aqueous levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy. METHODS: The study included three age and gender-matched groups of 20 cataract patients with no diabetes or additional disease ...
Fatih Cem Gül +4 more
doaj +1 more source
Pannexin-1 channel regulates nuclear content packaging into apoptotic bodies and their size [PDF]
, 2021 Apoptotic bodies (ApoBDs), which are large extracellular vesicles exclusively released by apoptotic cells, possess therapeutically exploitable properties including biomolecule loadability and transferability.
Ivan Poon (9481238) +7 more
core +1 more source
Investigation of Gasdermin-D and Pannexin-1 in Omental Adipose and Placental Tissues in Obese Pregnant Women [PDF]
Haseki Tıp BülteniAim: Gasdermin-D (GSDMD) and pannexin-1 (PANX1), which are proinflammatory proteins, may be involved in the pathogenesis of complications in pregnant women with obesity.
Fatma Karasabanoglu +5 more
doaj +3 more sources
Dual Regulatory Roles of Pannexin 1 in the Pathogenesis and Recovery of Sepsis-Induced Acute Lung Injury. [PDF]
Infect Drug ResistQiancheng Xu,1,* Yan Qian,2,* Yingya Cao,1 Weihua Lu,1 Jianguo Li3 1Department of Critical Care Medicine, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, Anhui, 241000, People’s
Xu Q, Qian Y, Cao Y, Lu W, Li J.
europepmc +3 more sources