Results 11 to 20 of about 21,240,958 (197)
Pannexin 1 activity in astroglia sets hippocampal neuronal network patterns [PDF]
PLoS Biology, 2022 Astroglial release of molecules is thought to actively modulate neuronal activity, but the nature, release pathway, and cellular targets of these neuroactive molecules are still unclear.
Flora Vasile +10 more
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Pannexin 1 channels in skeletal muscles [PDF]
Frontiers in Physiology, 2014 Normal myotubes and adult innervated skeletal myofibers express the glycoprotein pannexin1 (Panx1). Six of them form a gap junction hemichannel-like structure that connects the cytoplasm with the extracellular space; here they will be called Panx1 ...
Luis Andrés Cea +6 more
doaj +5 more sources
Low levels of pannexin‐1 in Behçet’s syndrome [PDF]
International Journal of Rheumatic Diseases, 2019 AbstractObjectiveBehçet's syndrome (BS) is a chronic, multisystemic and inflammatory syndrome. In our study, we aimed to compare the initiator, effector and inflammatory caspases and pannexin channel protein, which is thought to have an activity in inflammation, in the inflammatory process of BS, with healthy subjects, to investigate their level in ...
Ali Şahin +4 more
core +6 more sources
Emerging functions of Pannexin 1 in the eye [PDF]
Frontiers in Cellular Neuroscience, 2014 Pannexin 1 (Panx1) is a high-conductance, voltage-gated channel protein found in vertebrates. It has been shown that Panx1 is widely expressed in many organs and tissues, including sensory systems.
Sarah eKurtenbach +2 more
doaj +3 more sources
Perspectives on the role of Pannexin 1 in neural precursor cell biology [PDF]
Neural Regeneration Research, 2016 We recently reported that targeted deletion of Pannexin 1 in neural precursor cells of the ventricular zone impairs the maintenance of these cells in healthy and stroke-injured brain. Here we frame this exciting new finding in the context of our previous
Juan C Sanchez-Arias +2 more
doaj +2 more sources
Pannexin 1 Influences Lineage Specification of Human iPSCs [PDF]
Frontiers in Cell and Developmental Biology, 2021 Every single cell in the body communicates with nearby cells to locally organize activities with their neighbors and dysfunctional cell-cell communication can be detrimental during cell lineage commitment, tissue patterning and organ development ...
Rebecca J. Noort +2 more
doaj +5 more sources
The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes [PDF]
Journal of Biological Chemistry, 2009 The inflammasome is a multiprotein complex involved in innate immunity. Activation of the inflammasome causes the processing and release of the cytokines interleukins 1beta and 18. In primary macrophages, potassium ion flux and the membrane channel pannexin 1 have been suggested to play roles in inflammasome activation. However, the molecular mechanism(
William R, Silverman +7 more
openaire +4 more sources
Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism. [PDF]
PLoS ONE, 2014 P2X7 is a ligand-gated ion channel which is activated by ATP and displays secondary permeability characteristics. The mechanism of development of the secondary permeability pathway is currently unclear, although a role for the hemichannel protein ...
Archana Bhaskaracharya +7 more
doaj +5 more sources
Pannexin 1 forms an anion-selective channel [PDF]
Pflügers Archiv - European Journal of Physiology, 2012 Pannexin 1 (Panx1) is expressed in various mammalian tissues including the brain and immune cells. Here, we present evidence that Panx1 when expressed in mammalian cells, forms anion-selective channels, with a rank order of permeabilities: NO (3) (-)> I(-) > Br (-)> Cl (-) > F (-)>> aspartate (-)≈ glutamate (-)≈ gluconate(-).
Ma, Weihong +6 more
openaire +4 more sources
Pannexin 1 in erythrocytes: Function without a gap [PDF]
Proceedings of the National Academy of Sciences, 2006 ATP is a widely used extracellular signaling molecule. The mechanism of ATP release from cells is presently unresolved and may be either vesicular or channel-mediated. Erythrocytes release ATP in response to low oxygen or to shear stress. In the absence of vesicles, the release has to be through channels. Erythrocytes do not form gap junctions.
Silviu, Locovei, Li, Bao, Gerhard, Dahl
openaire +4 more sources