Results 1 to 10 of about 13,116 (137)
Cells, 2021 The P2X7 receptor for extracellular ATP is a well-established mediator of tumoral development and progression both in solid cancers and hematological malignancies.
Elena Adinolfi +2 more
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Serum P2X7 as a prognostic biomarker in acute supratentorial intracerebral hemorrhage: a two-center observational study [PDF]
Frontiers in NeurologyIntroductionP2X7 participates in neuroinflammation underlying acute brain injury. In this study, we investigated the prognostic role of serum P2X7 in acute intracerebral hemorrhage (ICH).MethodsThis two-center observational analytic study enrolled 95 ...
Xinle Chen +7 more
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P2X7 is an important mediator of BMP9-induced osteogenic differentiation of mesenchymal stem cells [PDF]
Cell Communication and SignalingBackground Bone morphogenetic protein 9 (BMP9) has been demonstrated to robustly induce osteogenic differentiation of mesenchymal stem cells (MSCs), offering substantial potential for advancements in bone tissue engineering.
Lulu Zhang +6 more
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Affinity-guided labeling reveals P2X7 nanoscale membrane redistribution during BV2 microglial activation [PDF]
eLifeATP-gated purinergic P2X7 receptors are crucial ion channels involved in inflammation. They sense abnormal ATP release during stress or injury and are considered promising clinical targets for therapeutic intervention.
Benoit Arnould +9 more
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Frontiers in Pharmacology, 2022 The P2X7 ion channel is a key sensor for extracellular ATP and a key trigger of sterile inflammation. Intravenous injection of nanobodies that block P2X7 has shown to be beneficial in mouse models of systemic inflammation.
Carolina Pinto-Espinoza +17 more
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P2X7 receptor in inflammation and pain
Brain Research Bulletin, 2022 Different studies have confirmed P2X7 receptor-mediated inflammatory mediators play a key role in the development of pain. P2X7 receptor activation can induce the development of pain by mediating the release of inflammatory mediators. In view of the fact
Shi-qi Hu +7 more
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P2X7 Purinoceptor Affects Ectopic Calcification of Dystrophic Muscles
Frontiers in Pharmacology, 2022 Ectopic calcification (EC) of myofibers is a pathological feature of muscle damage in Duchenne muscular dystrophy (DMD). Mineralisation of muscle tissue occurs concomitantly with macrophage infiltration, suggesting a link between ectopic mineral ...
Robin M. H. Rumney +6 more
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P2X7 in Cancer: From Molecular Mechanisms to Therapeutics
Frontiers in Pharmacology, 2020 P2X7 is a transmembrane receptor expressed in multiple cell types including neurons, dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of physiological responses from pain transduction to immune response.
Romain Lara +6 more
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Frontiers in Molecular Neuroscience, 2020 The ionotropic ATP-gated P2X7 receptor is an important contributor to inflammatory signaling cascades via the release of Interleukin-1β, as well as having roles in cell death, neuronal plasticity and the release of neurotransmitters.
Giorgia Conte +11 more
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Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation. [PDF]
PLoS ONE, 2012 P2X7 is a homotrimeric ion channel with two transmembrane domains and a large extracellular ATP-binding domain. It plays a key role in the response of immune cells to danger signals released from cells at sites of inflammation.
Nicole Schwarz +8 more
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