Results 1 to 10 of about 25,301 (246)

P2X7 Variants in Oncogenesis [PDF]

Cells, 2021
The P2X7 receptor for extracellular ATP is a well-established mediator of tumoral development and progression both in solid cancers and hematological malignancies.
Elena Adinolfi, Anna Pegoraro, Elena de Marchi   +2 more
exaly   +8 more sources

Blocking P2X7 by intracerebroventricular injection of P2X7-specific nanobodies reduces stroke lesions [PDF]

Journal of Neuroinflammation, 2022
Background Previous studies have demonstrated that purinergic receptors could be therapeutic targets to modulate the inflammatory response in multiple models of brain diseases.
Maximilian Wilmes, Carolina Pinto Espinoza, Peter Ludewig, Joschi Stabernack, Arthur Liesz, Annette Nicke, Mathias Gelderblom, Christian Gerloff, Simonetta Falzoni, Eva Tolosa, Francesco Di Virgilio, Björn Rissiek, Nikolaus Plesnilla, Friedrich Koch-Nolte, Tim Magnus   +14 more
doaj   +7 more sources

P2X7 receptor in inflammation and pain

Brain Research Bulletin, 2022
Different studies have confirmed P2X7 receptor-mediated inflammatory mediators play a key role in the development of pain. P2X7 receptor activation can induce the development of pain by mediating the release of inflammatory mediators. In view of the fact
Shi-qi Hu, Jia-ling Hu, Fei-long Zou, Ji-peng Liu, Hong-liang Luo, Dong-xia Hu, Li-dong Wu, Wen-jun Zhang   +7 more
doaj   +4 more sources

P2X7 in Cancer: From Molecular Mechanisms to Therapeutics

Frontiers in Pharmacology, 2020
P2X7 is a transmembrane receptor expressed in multiple cell types including neurons, dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of physiological responses from pain transduction to immune response.
Romain Lara, Elena Adinolfi, Catherine A. Harwood, Mike Philpott, Julian A. Barden, Francesco Di Virgilio, Shaun McNulty   +6 more
doaj   +2 more sources

Mesenchymal stem cells as cellular factories for targeted P2X7 blockade after traumatic brain injury. [PDF]

Neuroprotection
This manuscript presents a novel therapeutic strategy using mesenchymal stem cells (MSCs) engineered as living drug factories to deliver a P2X7‐blocking nanobody for treatment of ischemic stroke. By combining targeted cellular delivery with sustained local immunomodulation, the approach aims to overcome key limitations of systemic biologic ...
Fadon-Padilla L, Chu C, McDougall L, Liang Y, Sarkar C, Lipinski M, Magnus T, Janowski M, Walczak P.   +8 more
europepmc   +2 more sources

P2X7 promotes metastatic spreading and triggers release of miRNA-containing exosomes and microvesicles from melanoma cells

Cell Death and Disease, 2021
Tumor growth and metastatic spreading are heavily affected by the P2X7 receptor as well as microvesicles and exosomes release into the tumor microenvironment. P2X7 receptor stimulation is known to trigger vesicular release from immune and central nervous
Anna Pegoraro, Elena De Marchi, Manuela Ferracin, Elisa Orioli, Michele Zanoni, Cristian Bassi, Anna Tesei, Marina Capece, Emi Dika, Massimo Negrini, Francesco Di Virgilio, Elena Adinolfi   +11 more
doaj   +2 more sources

The P2X7 Receptor: Central Hub of Brain Diseases

Frontiers in Molecular Neuroscience, 2020
The P2X7 receptor is a cation channel activated by high concentrations of adenosine triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming a wide pore that leads to cell death and increased release of ATP into the ...
Roberta Andrejew, Ágatha Oliveira-Giacomelli, Deidiane Elisa Ribeiro, Talita Glaser, Vanessa Fernandes Arnaud-Sampaio, Claudiana Lameu, Henning Ulrich   +6 more
doaj   +2 more sources

ATP Release and Purinergic Signaling Potentiate β-Adrenergic Effects on Brown Adipocytes. [PDF]

Acta Physiol (Oxf)
ABSTRACT Aim Brown adipose tissue (BAT) specializes in energy consumption and thermogenesis in response to cold stress. Brown adipocytes (BA) express purinergic receptors, yet little is known about the source of extracellular ATP and the role of purinergic signaling, and the potential interaction with β‐adrenergic signaling.
Tozzi M, Berggreen EB, Zhang R, Gudiksen A, Li W, Matz MB, Pilegaard H, Hansen JB, Novak I.   +8 more
europepmc   +2 more sources

P2X7 is an important mediator of BMP9-induced osteogenic differentiation of mesenchymal stem cells [PDF]

Cell Communication and Signaling
Background Bone morphogenetic protein 9 (BMP9) has been demonstrated to robustly induce osteogenic differentiation of mesenchymal stem cells (MSCs), offering substantial potential for advancements in bone tissue engineering.
Lulu Zhang, Ziyun Li, Yannian Gou, Habu Jiwa, Jiayu Wang, Wei Zhang, Jinyong Luo   +6 more
doaj   +2 more sources

Targeted P2X7/NLRP3 signaling pathway against inflammation, apoptosis, and pyroptosis of retinal endothelial cells in diabetic retinopathy

Cell Death and Disease, 2022
Retinal endothelial cells (RECs) are the primary target cells for diabetes-induced vascular damage. The P2X7/NLRP3 pathway plays an essential role in amplifying inflammation via an ATP feedback loop, promoting the inflammatory response, pyroptosis, and ...
Hui Kong, Hong-Ran Zhao, Tianran Chen, Yanling Song, Yan Cui   +4 more
semanticscholar   +1 more source