Results 11 to 20 of about 13,166 (177)
P2X7 Receptor in Hematological Malignancies [PDF]
Frontiers in Cell and Developmental Biology, 2021 The P2X7 receptor is an ion channel gated by the nucleotide ATP, known for its role in immune responses and recently emerging as a critical onco-promoting factor.
Elena De Marchi +2 more
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Journal of Neuroinflammation, 2022 Background Previous studies have demonstrated that purinergic receptors could be therapeutic targets to modulate the inflammatory response in multiple models of brain diseases.
Maximilian Wilmes +14 more
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The P2X7 Receptor in Osteoarthritis [PDF]
Frontiers in Cell and Developmental Biology, 2021 Osteoarthritis (OA) is the most common joint disease. With the increasing aging population, the associated socio-economic costs are also increasing. Analgesia and surgery are the primary treatment options in late-stage OA, with drug treatment only possible in early prevention to improve patients’ quality of life. The most important structural component
Zihao Li, Ziyu Huang, Lunhao Bai
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The P2X7 Receptor in Autoimmunity
International Journal of Molecular Sciences, 2023 The P2X7 receptor (P2X7R) is an ATP-gated nonselective cationic channel that, upon intense stimulation, can progress to the opening of a pore permeable to molecules up to 900 Da. Apart from its broad expression in cells of the innate and adaptive immune systems, it is expressed in multiple cell types in different tissues.
Fabio Grassi, Gaia Salina
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The P2X7 Receptor in Tumor Immunity [PDF]
Frontiers in Cell and Developmental Biology, 2021 Extracellular adenosine triphosphate (eATP) is a potent mediator of the immune response via stimulation of purinergic P2 receptors. ATP concentration in the extracellular space increases dramatically during tissue damage and eATP acts as a danger-associated molecular pattern (DAMP) to alert innate immune system cells for tissue repair.
Fabio Grassi +2 more
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تأثیر تمرینات HIIT بر تغییرات Pannexin-1،P2X7، NLRP-1 بافت قلب موشهای صحرایی نر نژاد ویستار مبتلا به دیابت نوع 2 [PDF]
مجله دانشکده پزشکی اصفهانمقاله پژوهشیمقدمه: هدف پژوهش حاضر، مطالعهی تأثیر تمرینات HIIT بر تغییرات سطوح پروتئینهای Pannexin-1، P2X7، NLRP-1 بافت قلب موشهای صحرایی نر نژاد ویستار مبتلا به دیابت نوع 2 میباشد.روشها: در این مطالعه، تعداد 40 سر موش صحرایی نر 8 هفتهای از نژاد ...
یاسمن رفیعی +3 more
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The role of microglial P2X7: modulation of cell death and cytokine release
Journal of Neuroinflammation, 2017 Background ATP-gated P2X7 is a non-selective cation channel, which participates in a wide range of cellular functions as well as pathophysiological processes including neuropathic pain, immune response, and neuroinflammation.
Yingbo He +3 more
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Recent Advances in CNS P2X7 Physiology and Pharmacology: Focus on Neuropsychiatric Disorders
Frontiers in Pharmacology, 2018 The ATP-gated P2X7 ion channel is an abundant microglial protein in the CNS that plays an important pathological role in executing ATP-driven danger signal transduction.
Anindya Bhattacharya
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P2X7 promotes the progression of MLL-AF9 induced acute myeloid leukemia by upregulation of Pbx3
Haematologica, 2020 Nucleotides mediate intercellular communication by activating purinergic receptors and take part in various physiological and pathological processes. Abnormal purinergic signaling plays important roles in malignant progression. P2X7, which belongs to the
Wenli Feng +10 more
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Journal of Inflammation Research, 2022 Moumita Saha,1 Krishnendu Manna,2 Krishna Das Saha1 1Cancer Biology and Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, Kolkata, West Bengal, India; 2Department of Food and Nutrition, University of Kalyani, Kalyani, West Bengal,
Saha M, Manna K, Das Saha K
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