Results 11 to 20 of about 25,301 (246)
P2X7 Variants in Pathophysiology
International Journal of Molecular SciencesP2X7 receptor activation by extracellular adenosine triphosphate (eATP) modulates different intracellular pathways, including pro-inflammatory and tumor-promoting cascades.
Anna Pegoraro +4 more
semanticscholar +6 more sources
P2X7 Receptor in Hematological Malignancies [PDF]
Frontiers in Cell and Developmental Biology, 2021 The P2X7 receptor is an ion channel gated by the nucleotide ATP, known for its role in immune responses and recently emerging as a critical onco-promoting factor.
Elena De Marchi +2 more
doaj +5 more sources
Frontiers in Pharmacology, 2022 The P2X7 ion channel is a key sensor for extracellular ATP and a key trigger of sterile inflammation. Intravenous injection of nanobodies that block P2X7 has shown to be beneficial in mouse models of systemic inflammation.
Carolina Pinto-Espinoza +17 more
doaj +2 more sources
Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody [PDF]
eLife, 2018 The P2X7 channel is involved in the pathogenesis of various CNS diseases. An increasing number of studies suggest its presence in neurons where its putative functions remain controversial for more than a decade.
Karina Kaczmarek-Hajek +16 more
doaj +3 more sources
The P2X7 Receptor Channel: Recent Developments and the Use of P2X7 Antagonists in Models of Disease
Pharmacological Reviews, 2014 The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not exclusively, on immune cells. P2X7 activation results in a number of downstream events, including the release of proinflammatory mediators and cell death and proliferation.
Bartlett, Rachael +2 more
core +6 more sources
The P2X7 Receptor in Infection and Inflammation [PDF]
Immunity, 2017 Adenosine triphosphate (ATP) accumulates at sites of tissue injury and inflammation. Effects of extracellular ATP are mediated by plasma membrane receptors named P2 receptors (P2Rs). The P2R most involved in inflammation and immunity is the P2X7 receptor (P2X7R), expressed by virtually all cells of innate and adaptive immunity.
F. Di Virgilio +4 more
semanticscholar +5 more sources
The P2X7 Receptor in Osteoarthritis [PDF]
Frontiers in Cell and Developmental Biology, 2021 Osteoarthritis (OA) is the most common joint disease. With the increasing aging population, the associated socio-economic costs are also increasing. Analgesia and surgery are the primary treatment options in late-stage OA, with drug treatment only possible in early prevention to improve patients’ quality of life. The most important structural component
Zihao Li, Ziyu Huang, Lunhao Bai
openaire +3 more sources
International Journal of Molecular Sciences, 2023 Diabetic cardiomyopathy (DCM) is a critical complication of long-term chronic diabetes mellitus, and it is characterized by myocardial fibrosis and myocardial hypertrophy.
Shu-Chan Sun +10 more
semanticscholar +1 more source
Chemosphere, 2023 Microplastics (MPs) and cadmium (Cd) are important environmental pollutants, that damage the liver. However, the effect and mechanism of combined Cd and MPs exposure on liver fibrosis are still largely unknown.
Jian Sun +10 more
semanticscholar +1 more source
The P2X7 Receptor in Autoimmunity
International Journal of Molecular Sciences, 2023 The P2X7 receptor (P2X7R) is an ATP-gated nonselective cationic channel that, upon intense stimulation, can progress to the opening of a pore permeable to molecules up to 900 Da. Apart from its broad expression in cells of the innate and adaptive immune systems, it is expressed in multiple cell types in different tissues.
Fabio Grassi, Gaia Salina
openaire +4 more sources