Results 41 to 50 of about 25,301 (246)

Aluminum induces neuroinflammation via P2X7 receptor activating NLRP3 inflammasome pathway.

Ecotoxicology and Environmental Safety, 2022
INTRODUCTION Aluminum is everywhere in nature and is a recognized neurotoxicant closely associated with various neurodegenerative diseases. Neuroinflammation occurs in the early stage of neurodegenerative diseases, but the underlying mechanism by which ...
Xiaoying Zhu, Wudi Hao, Zi-Yue Liu, Yushuai Song, Chenyu Hao, Sheng-Wen Wu, Xiaobo Lu, Jing-Hua Yang, Cui-Hong Jin   +8 more
semanticscholar   +1 more source

Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors. [PDF]

, 2013
Recent investigations have revealed that the genetic deletion of P2X7 receptors (P2rx7) results in an antidepressant phenotype in mice. However, the link between the deficiency of P2rx7 and changes in behavior has not yet been explored.
Zsilla Gabriella, Csölle Cecília, Csölle, Cecília, Illes Peter, Flóra Gölöncsér, Gabriella Zsilla, Mária Baranyi, Sperlágh, Beáta, Baranyi, Mária, Kittel Ágnes, Peter Illes, Baranyi Mária, Beáta Sperlágh, Vizi E. Szilveszter, E Sylvester Vizi, Zsilla, Gabriella, Papp Edit, Gölöncsér Flóra, Illés, Péter, Gölöncsér, Flóra, E. Sylvester Vizi, Sperlágh Beáta, Illes P, Vizi, E. Szilveszter, Papp, Edit, Edit Papp, Kittel, Ágnes, Agnes Kittel, Cecilia Csölle, Vizi E. Sylvester   +29 more
core   +2 more sources

The role of microglial P2X7: modulation of cell death and cytokine release

Journal of Neuroinflammation, 2017
Background ATP-gated P2X7 is a non-selective cation channel, which participates in a wide range of cellular functions as well as pathophysiological processes including neuropathic pain, immune response, and neuroinflammation.
Yingbo He, Natalie Taylor, Lawrence Fourgeaud, Anindya Bhattacharya   +3 more
doaj   +1 more source

The P2X7 Receptor in Microglial Cells Modulates the Endolysosomal Axis, Autophagy, and Phagocytosis

Frontiers in Cellular Neuroscience, 2021
Microglial cells regulate neural homeostasis by coordinating both immune responses and clearance of debris, and the P2X7 receptor for extracellular ATP plays a central role in both functions.
Keith E Campagno, C. Mitchell
semanticscholar   +1 more source

Maternal P2X7 receptor inhibition prevents autism-like phenotype in male mouse offspring through the NLRP3-IL-1β pathway.

Brain, behavior, and immunity, 2022
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition caused by interactions of environmental and genetic factors. Recently we showed that activation of the purinergic P2X7 receptors is necessary and sufficient to convert maternal ...
Dorottya Szabó, Pál Tod, F. Gölöncsér, V. Román, B. Lendvai, Lilla Otrokocsi, B. Sperlágh   +6 more
semanticscholar   +1 more source

Recent Advances in CNS P2X7 Physiology and Pharmacology: Focus on Neuropsychiatric Disorders

Frontiers in Pharmacology, 2018
The ATP-gated P2X7 ion channel is an abundant microglial protein in the CNS that plays an important pathological role in executing ATP-driven danger signal transduction.
Anindya Bhattacharya
doaj   +1 more source

P2X7 promotes the progression of MLL-AF9 induced acute myeloid leukemia by upregulation of Pbx3

Haematologica, 2020
Nucleotides mediate intercellular communication by activating purinergic receptors and take part in various physiological and pathological processes. Abnormal purinergic signaling plays important roles in malignant progression. P2X7, which belongs to the
Wenli Feng, Xiao Yang, Lina Wang, Rong Wang, Feifei Yang, Hao Wang, Xiaoli Liu, Qian Ren, Yingchi Zhang, Xiaofan Zhu, Guoguang Zheng   +10 more
doaj   +1 more source

P2X7 receptor signaling during adult hippocampal neurogenesis [PDF]

, 2019
Neurogenesis is a persistent and essential feature of the adult mammalian hippocampus. Granular neurons generated from resident pools of stem or progenitor cells provide a mechanism for the formation and consolidation of new memories.
Lovelace, Michael, Leeson, Hannah, Chan-Ling, Tailoi, Leeson, H, Leeson, Hannah C, Weible, Michael, Brownlie, Jeremy C, Gu, Ben J, Lovelace, Michael D, Gu, Ben, Chan-Ling, T, Weible, Michael W, Brownlie, J, Brownlie, Jeremy, Lovelace, M ; https://orcid.org/, Weible, M, Gu, B   +16 more
core   +1 more source

Melatonin Suppresses NLRP3 Inflammasome Activation via TLR4/NF-κB and P2X7R Signaling in High-Fat Diet-Induced Murine NASH Model

Journal of Inflammation Research, 2022
Moumita Saha,1 Krishnendu Manna,2 Krishna Das Saha1 1Cancer Biology and Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, Kolkata, West Bengal, India; 2Department of Food and Nutrition, University of Kalyani, Kalyani, West Bengal,
Saha M, Manna K, Das Saha K
doaj  

P2X7 Receptor Modulation of the Gut Microbiota and the Inflammasome Determines the Severity of Toxoplasma gondii-Induced Ileitis

Biomedicines, 2023
In mice, oral Toxoplasma gondii infection induces severe ileitis. The aim of the present study was to investigate the impact of the P2X7 receptor (P2X7) on the inflammatory response to T. gondii-induced ileitis. Cysts of the ME49 strain of T. gondii were
Aline Cristina Abreu Moreira-Souza, Hayandra Ferreira Nanini, Thuany Prado Rangel, Sthefani Rodrigues Batista da Silva, Beatriz Pêgo Damasceno, Beatriz Elias Ribeiro, Cynthia M. Cascabulho, Fabiano Thompson, Camille Leal, Patrícia Teixeira Santana, Siane Lopes Bittencourt Rosas, Kívia Queiroz de Andrade, Claudia L. Martins Silva, Rossiane Claudia Vommaro, Heitor Siffert Pereira de Souza, Robson Coutinho-Silva   +15 more
doaj   +1 more source