Results 61 to 70 of about 25,301 (246)

The cellular distribution of P2X7, P2Y6, and P2Y12 during or after pilocarpine-induced status epilepticus and literature review

Brain Circulation
BACKGROUND: When a seizure occurs, the distribution of purine receptors in different cell types at various time points remains poorly understood. Our literature review revealed that P2X7, P2Y6, and P2Y12 are expressed in different cells during epilepsy ...
Yue Li, Fengru Tang, Yumin Luo
doaj   +1 more source

Increased P2X7 Receptor Binding Is Associated With Neuroinflammation in Acute but Not Chronic Rodent Models for Parkinson’s Disease

Frontiers in Neuroscience, 2019
The purinergic P2X7 receptor is a key mediator in (neuro)inflammation, a process that is associated with neurodegeneration and excitotoxicity in Parkinson’s disease (PD). Recently, P2X7 imaging has become possible with [11C]JNJ-(54173)717.
Melissa Crabbé, Melissa Crabbé, Anke Van der Perren, Anke Van der Perren, Ilse Bollaerts, Savannah Kounelis, Savannah Kounelis, Veerle Baekelandt, Veerle Baekelandt, Veerle Baekelandt, Guy Bormans, Guy Bormans, Cindy Casteels, Cindy Casteels, Lieve Moons, Lieve Moons, Koen Van Laere, Koen Van Laere   +17 more
doaj   +1 more source

P2X7 mediates ATP-driven invasiveness in prostate cancer cells. [PDF]

PLoS ONE, 2014
The ATP-gated P2X7 has been shown to play an important role in invasiveness and metastasis of some tumors. However, the possible links and underlying mechanisms between P2X7 and prostate cancer have not been elucidated.
Ying Qiu, Wei-Hua Li, Hong-Quan Zhang, Yan Liu, Xin-Xia Tian, Wei-Gang Fang   +5 more
doaj   +1 more source

Structural basis for the functional properties of the P2X7 receptor for extracellular ATP

Purinergic Signalling Purinergic Signalling, 2021
The P2X7 receptor, originally known as the P2Z receptor due to its distinctive functional properties, has a structure characteristic of the ATP-gated ion channel P2X receptor family.
Lin-Hua Jiang, Emily A. Caseley, S. Muench, Sébastien Roger   +3 more
semanticscholar   +1 more source

IRE1-mTOR-PERK Axis Coordinates Autophagy and ER Stress-Apoptosis Induced by P2X7-Mediated Ca2+ Influx in Osteoarthritis

Frontiers in Cell and Developmental Biology, 2021
Moderate-intensity exercise can help delay the development of osteoarthritis (OA). Previous studies have shown that the purinergic receptor P2X ligand gated ion channel 7 (P2X7) is involved in OA development and progression.
Zihao Li, Ziyu Huang, He Zhang, Jinghan Lu, Yingliang Wei, Yue Yang, L. Bai   +6 more
semanticscholar   +1 more source

Interaction of Purinergic P2X4 and P2X7 Receptor Subunits

Frontiers in Pharmacology, 2017
P2X4 and P2X7 are members of the P2X receptor family, comprising seven isoforms (P2X1–P2X7) that form homo- and heterotrimeric non-specific cation channels gated by extracellular ATP.
Markus Schneider, Kirsten Prudic, Anja Pippel, Manuela Klapperstück, Ursula Braam, Christa E. Müller, Günther Schmalzing, Fritz Markwardt   +7 more
doaj   +1 more source

Rapid morphologic changes to microglial cells and upregulation of mixed microglial activation state markers induced by P2X7 receptor stimulation and increased intraocular pressure

Journal of Neuroinflammation, 2021
The identification of endogenous signals that lead to microglial activation is a key step in understanding neuroinflammatory cascades. As ATP release accompanies mechanical strain to neural tissue, and as the P2X7 receptor for ATP is expressed on ...
Keith E Campagno, Wen-Nan Lu, A. H. Jassim, Farraj Albalawi, Aurora Cenaj, Huen-Yee Tso, Sophia P Clark, Puttipong Sripinun, N. M. Gómez, C. Mitchell   +9 more
semanticscholar   +1 more source

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

P2X7 Receptor: Warburg effect revisited [PDF]

, 2012
Ability to adapt to conditions of limited nutrient supply is a key feature of all cells. This may require a complex re-organization of metabolic pathways to balance energy generation and production of biosynthetic intermediates.
Amoroso, Francesca Saveria
core  

Gabapentinoids‐duloxetine combination therapy for chronic pain: A mechanism oriented rational to bridge theoretical knowledge and real life setting

British Journal of Clinical Pharmacology, EarlyView.
Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili, Maurizio Evangelista, Elena Lucarini, Elena G. Giugliano, Carla Ghelardini, Laura Micheli, Lorenzo Di Cesare Mannelli   +6 more
wiley   +1 more source