Results 51 to 60 of about 13,166 (177)

Synergistic Effects of Bacterial Mimetic and Mechanical Stimulation in Dental Pulp Cell Inflammatory Signalling: A Laboratory Investigation

International Endodontic Journal, EarlyView.
ABSTRACT Objectives Mechanical and/or microbial stimuli can prompt extracellular ATP release in many cell types, where it acts as an inflammatory mediator to amplify pain signals and inflammation. This study aimed to investigate the synergistic effects of microbial and/or mechanical stimulation on ATP and cytokine release from dental pulp cells (DPCs ...
Orla M. Dunne, Lorcan P. McGarvey, Imad About, Fionnuala T. Lundy, Ikhlas El‐Karim   +4 more
wiley   +1 more source

Periodontitis as a Model for Inflammatory Uncoupling of Bone Remodeling

Journal of Periodontal Research, EarlyView.
Periodontitis can be viewed as a state of inflammatory uncoupling of bone remodeling, in which excessive osteoclast‐mediated resorption coexists with impaired bone formation. This review integrates emerging insights from osteoimmunology, osteocyte biology, mechanobiology, aging, and resolution pathways to position periodontitis as an accessible in vivo
Rafael Scaf de Molon, Sotirios Tetradis, Rolando Vernal, Fabio Renato Manzolli Leite, Thomas E. Van Dyke   +4 more
wiley   +1 more source

Antipsychotics‐Induced Hyposalivation Mediated by Impaired Salivary Ca2+ Signaling

Oral Diseases, EarlyView.
ABSTRACT Objectives Antipsychotic‐induced salivary dysfunction such as hyposalivation is a prevalent clinical challenge that severely compromises oral health and quality of life. Although typical and atypical antipsychotics have their therapeutic target in the central nervous system, their direct molecular mechanisms within the salivary glands remain ...
Chaelin Chung, Soohyun Kim, Yoo‐Bin Kim, Hee‐Kyung Park, Se‐Young Choi   +4 more
wiley   +1 more source

Different localization of P2X4 and P2X7 receptors in native mouse lung - lack of evidence for a direct P2X4-P2X7 receptor interaction

Frontiers in Immunology
IntroductionP2X receptors are a family of homo- and heterotrimeric cation channels gated by extracellular ATP. The P2X4 and P2X7 subunits show overlapping expression patterns and have been involved in similar physiological processes, such as pain and ...
Juan Sierra-Marquez, Lena Schaller, Lukas Sassenbach, Antonio Ramírez-Fernández, Philipp Alt, Björn Rissiek, Béla Zimmer, Johann Schredelseker, Johann Schredelseker, Julia Hector, Tobias Stähler, Friedrich Koch-Nolte, Claudia A. Staab-Weijnitz, Claudia A. Staab-Weijnitz, Alexander Dietrich, Robin Kopp, Annette Nicke   +16 more
doaj   +1 more source

AMPK-dependent and independent actions of P2X7 in regulation of mitochondrial and lysosomal functions in microglia

Cell Communication and Signaling, 2018
Background P2X7 is ubiquitously expressed in myeloid cells and regulates the pathophysiology of inflammatory diseases. Since mitochondrial function in microglia is highly associated with microglial functions in controlling neuronal plasticity and brain ...
Ponarulselvam Sekar, Duen-Yi Huang, Shie-Liang Hsieh, Shwu-Fen Chang, Wan-Wan Lin   +4 more
doaj   +1 more source

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

ATP/P2X7 receptor signal aggravates ischemic stroke injury by activating Th17 cells via STAT3/IL-21 pathway

Frontiers in Immunology
BackgroundDuring cerebral ischemia, adenosine triphosphate (ATP) is released into the extracellular matrix from damaged neurons and glial cells, functioning as a danger signal.
Wenying Liu, Wenying Liu, Denghui Li, Mengjie Zhang, Jun Yin, Peng Wang, Paiyu Liu, Zhiqiang Song, Bing Ni, Yanmeng Peng   +9 more
doaj   +1 more source

Understanding exosomes in regenerative dentistry

Periodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad, Anton Sculean, Richard J. Miron   +2 more
wiley   +1 more source

Tyrosine Phosphorylation of HSP90 within the P2X7 Receptor Complex Negatively Regulates P2X7 Receptors [PDF]

Journal of Biological Chemistry, 2003
The purinergic P2X7 receptor not only gates the opening of a cationic channel, but also couples to several downstream signaling events such as rapid membrane blebbing, microvesicle shedding, and interleukin-1beta release. Protein-protein interactions are likely to be involved in most of these signaling cascades; and recently, a P2X7 receptor-protein ...
ADINOLFI, Elena, KIM M, YOUNG MT, DI VIRGILIO, Francesco, SURPRENANT A.   +4 more
openaire   +6 more sources

Electromagnetic field treatment increases purinergic receptor P2X7 expression and activates its downstream Akt/GSK3β/β-catenin axis in mesenchymal stem cells under osteogenic induction

Stem Cell Research & Therapy, 2019
Background Imbalance in bone formation and resorption is a crucial component of the pathological process leading to osteoporosis. Electromagnetic fields (EMFs) have been reported to be beneficial to osteogenesis, although the exact mechanism has not been
Yingchi Zhang, Wenkai Li, Chaoxu Liu, Jiyuan Yan, Xuefeng Yuan, Wei Wang, Huaixi Wang, Hua Wu, Yong Yang   +8 more
doaj   +1 more source