Results 51 to 60 of about 25,301 (246)
Cell Death Discovery, 2021 Instability and excessive use of the knee joint can cause osteoarthritis (OA). Reasonable exercise can enhance the stability of the knee joint and prevent and relieve the occurrence and development of OA.
Zihao Li +7 more
semanticscholar +1 more source
Rod and cone pathway signalling is altered in the P2X7 receptor knock out mouse.
PLoS ONE, 2012 The P2X7 receptor (P2X7-R) is expressed in the retina and brain and has been implicated in neurodegenerative diseases. However, whether it is expressed by neurons and plays a role as a neurotransmitter receptor has been the subject of controversy.
Kirstan A Vessey, Erica L Fletcher
doaj +1 more source
6-Furopyridine Hexamethylene Amiloride Is a Non-Selective P2X7 Receptor Antagonist
Biomolecules, 2022 P2X7 is an extracellular adenosine 5′-triphopshate (ATP)-gated cation channel present on leukocytes, where its activation induces pro-inflammatory cytokine release and ectodomain shedding of cell surface molecules.
Peter Cuthbertson +12 more
doaj +1 more source
The P2X7 Carboxyl Tail Is a Regulatory Module of P2X7 Receptor Channel Activity [PDF]
Journal of Biological Chemistry, 2008 P2X(7) receptors are ATP-gated cation channels composed of three identical subunits, each having intracellular amino and carboxyl termini and two transmembrane segments connected by a large ectodomain. Within the P2X family, P2X(7) subunits are unique in possessing an extended carboxyl tail.
Daniel, Becker +6 more
openaire +2 more sources
bioRxiv, 2022 Inflammation is a tightly coordinated response against bacterial and viral infections, triggered by the production of pro-inflammatory cytokines. SARS-CoV-2 infection induces COVID-19 disease, characterized by an inflammatory response mediated through ...
J. García-Villalba +7 more
semanticscholar +1 more source
Frontiers in Cellular Neuroscience, 2021 Purinergic receptors play important roles in central nervous system (CNS), where the bulk of these receptors are implicated in neuroinflammatory responses and regulation of cellular function of neurons, microglial and astrocytes.
P. Territo, H. Zarrinmayeh
semanticscholar +1 more source
An S-Palmitoyltransferase Modulates P2X7 Function [PDF]
, 2015 The P2X7 receptor is an ATP gated ion channel that plays significant roles in the immune response and neurodegeneration. In a heterologous system, P2X7 channels open only when triggered by a high concentration of ATP (EC50 [ALMOST EQUAL TO] 100 to 1000 ...
Levenstein, Daniel
core +6 more sources
Role of P2X7 Receptors in Immune Responses During Neurodegeneration
Frontiers in Cellular Neuroscience, 2021 P2X7 receptors are ion-gated channels activated by ATP. Under pathological conditions, the extensive release of ATP induces sustained P2X7 receptor activation, culminating in induction of proinflammatory pathways with inflammasome assembly and cytokine ...
Ágatha Oliveira-Giacomelli +6 more
semanticscholar +1 more source
Journal of NeuroinflammationNeuroinflammation is highly influenced by microglia, particularly through activation of the NLRP3 inflammasome and subsequent release of IL-1β. Extracellular ATP is a strong activator of NLRP3 by inducing K^+ efflux as a key signaling event, suggesting ...
A. Rifat +14 more
semanticscholar +1 more source
P2X7 Receptor–Mediated Inflammation in Cardiovascular Disease
Frontiers in Pharmacology, 2021 Purinergic P2X7 receptor, a nonselective cation channel, is highly expressed in immune cells as well as cardiac smooth muscle cells and endothelial cells.
Junteng Zhou +5 more
semanticscholar +1 more source