Results 71 to 80 of about 25,301 (246)
Scientific Reports, 2021 There is increasing evidence for the vulnerability of specific retinal ganglion cell (RGC) types in those with glaucoma and in animal models. In addition, the P2X7-receptor (P2X7-R) has been suggested to contribute to RGC death following stimulation and ...
Anna Y. M. Wang +6 more
doaj +1 more source
Alternatively Spliced Isoforms of the P2X7 Receptor: Structure, Function and Disease Associations
International Journal of Molecular Sciences, 2022 The P2X7 receptor (P2X7R) is an ATP-gated membrane ion channel that is expressed by multiple cell types. Following activation by extracellular ATP, the P2X7R mediates a broad range of cellular responses including cytokine and chemokine release, cell ...
Sophie K. F. De Salis +6 more
semanticscholar +1 more source
WONOEP appraisal: Biomarkers and treatment strategies beyond the synapse
Epilepsia, EarlyView.Abstract Epilepsy is a heterogeneous neurological disorder affecting more than 70 million people worldwide, posing significant challenges for clinicians due to its complex etiology, diverse manifestations, variable treatment responses, and the inability to predict seizures or disease onset reliably.
Mirte Scheper +11 more
wiley +1 more source
P2X7 Receptor Modulation of Visual Responses in the Retina [PDF]
, 2015 Adenosine 5’ triphosphate (ATP)-gated P2X7 receptors (P2X7Rs) are known to act as conduits for photoreceptor and retinal ganglion cell (RGC) damage, consequences of various neurodegenerative conditions within the visual pathway. Growing evidence supports
Chavda, S
core
P2X7 on mouse T cells: one channel, many functions
Frontiers in Immunology, 2015 The P2X7 receptor is an adenosine triphosphate (ATP)-gated cation channel that is expressed by several cells of the immune system. P2X7 is best known for its proinflammatory role in promoting inflammasome formation and release of mature IL-1β by innate ...
Björn eRissiek +6 more
doaj +1 more source
Organoid Coculture Models for Cancer Research and Immunotherapy
Med Research, EarlyView.This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang +9 more
wiley +1 more source
, 2013 Cells were pre-incubated or not with a specific inhibitor of P2X7 (BBG) at 20 µM for 20 minutes before incubation with HMW-HA or MMW-HA or LMW-HA at 0.2% for 24-hours. P2X7 activation was evaluated by YO-PRO-1 dye uptake.
Jean-Michel Warnet (298323) +3 more
core +1 more source
European Journal of Immunology, 2022 Extracellular ATP activates the P2X7 receptor, leading to inflammasome activation and release of pro‐inflammatory cytokines in monocytes. However, a detailed analysis of P2X7 receptor expression and function in the human T cell compartment has not been ...
Riekje Winzer +13 more
semanticscholar +1 more source
Environmental Toxicology, EarlyView.ABSTRACT Mold growth in damp indoor environments is a widespread problem associated with respiratory health effects, though causal mechanisms remain incompletely understood. We established a human cell‐based in vitro test system using bronchial epithelial cells (NuLi‐1) and macrophages (THP‐1) to assess inhalation toxicity and immunomodulatory effects ...
Anja Wolff +8 more
wiley +1 more source
Characterization of a functional P2X7-like receptor in cerebellar granule neurons from P2X7 knockout mice [PDF]
, 2005 The presence of ionotropic P2X7 receptor has been studied in mice brain from wild type and P2X7 receptor knockout animals. Western blot and immunocytochemical assays show the presence of a protein containing the P2X7 immunogenic epitopes in the brain of ...
Miras-Portugal, M. Teresa +5 more
core +1 more source