Results 81 to 90 of about 13,166 (177)

P2X7 receptor knockout does not alter renal function or prevent angiotensin II-induced kidney injury in F344 rats

Scientific Reports
P2X7 receptors mediate immune and endothelial cell responses to extracellular ATP. Acute pharmacological blockade increases renal blood flow and filtration rate, suggesting that receptor activation promotes tonic vasoconstriction.
Josselin Nespoux, Marie-Louise T. Monaghan, Natalie K. Jones, Kevin Stewart, Laura Denby, Alicja Czopek, John J. Mullins, Robert I. Menzies, Andrew H. Baker, Matthew A. Bailey   +9 more
doaj   +1 more source

P2X7 a new therapeutic target to block vesicle-dependent metastasis in colon carcinoma: Role of the A2A/CD39/CD73 axis

Cell Death and Disease
Extracellular vesicle-driven cancer metastasis represents a therapeutic challenge due to the lack of effective blocking drugs. Our study shows that activation of the P2X7 receptor on colon carcinoma cells causes the release of vesicles carrying CD39 and ...
Anna Pegoraro, Elena De Marchi, Luigia Ruo, Michele Zanoni, Sofia Chioccioli, Giovanna Caderni, Letizia Alfieri, Marianna Grignolo, Paola Ulivi, Alessandro Passardi, Graziana Gallo, Luca Antonioli, Francesco Di Virgilio, Elena Adinolfi   +13 more
doaj   +1 more source

Macrophage expression of P2X7 controls autoimmune uveitis

Journal of Neuroinflammation
The release of danger-associated molecular patterns (DAMPs) such as ATP from stressed or damaged cells is a key initiator of sterile inflammation. In autoimmune diseases, extracellular ATP acts as a potent pro-inflammatory signal by activating the ...
Paul-Alexandre Déchelle-Marquet, Yueshen Che, Camille Roux, Frédéric Blond, Kaitryn E. Ronning, Sébastien Augustin, Pauline Lagouge-Roussey, Caroline Nous, Sara Touhami, Bahram Bodaghi, Jean Kanellopoulos, Sahil Adriouch, Xavier Guillonneau, Florian Sennlaub, Cécile Delarasse   +14 more
doaj   +1 more source

Paradoxical P2X7 [PDF]

Science-Business eXchange, 2012
openaire   +1 more source

P2X7 receptor and neuroinflammation in neurodegenerative disorders: an autoradiography study with [ 18 F]JNJ-64413739. [PDF]

Nucl Med Commun
Ashok AH, Field S, Ramakrishnan NK, Thompson S, O'Brien JT, Aigbirhio FI.   +5 more
europepmc   +1 more source

Positive allosteric modulator activity of ginsenosides is restricted to P2X7 and P2X4 receptors. [PDF]

Purinergic Signal
Allum E, Stokes L.
europepmc   +2 more sources

Transition-state analysis of the arginine-specific human ADP-ribosyltransferase 1. [PDF]

Proc Natl Acad Sci U S A
Groom DP, Aguilan JT, Lopacinski A, Garforth SJ, Schramm VL.   +4 more
europepmc   +1 more source

Increased P2X7 level does not affect anxiety or stress-coping behavior in male mice. [PDF]

Purinergic Signal
Urbina-Treviño L, Tang H, von Mücke-Heim IA, Engel T, Nicke A, Deussing JM.   +5 more
europepmc   +1 more source

P2X7 receptor [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

P2X7 receptors promote atrial remodeling and atrial fibrillation susceptibility via reactive oxygen species-mediated mitogen-activated protein kinase signaling activation. [PDF]

J Cell Commun Signal
Zhang L, Zhu Y, Gu X.
europepmc   +1 more source