Results 101 to 110 of about 25,301 (246)

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

Different localization of P2X4 and P2X7 receptors in native mouse lung - lack of evidence for a direct P2X4-P2X7 receptor interaction

Frontiers in Immunology
IntroductionP2X receptors are a family of homo- and heterotrimeric cation channels gated by extracellular ATP. The P2X4 and P2X7 subunits show overlapping expression patterns and have been involved in similar physiological processes, such as pain and ...
Juan Sierra-Marquez, Lena Schaller, Lukas Sassenbach, Antonio Ramírez-Fernández, Philipp Alt, Björn Rissiek, Béla Zimmer, Johann Schredelseker, Johann Schredelseker, Julia Hector, Tobias Stähler, Friedrich Koch-Nolte, Claudia A. Staab-Weijnitz, Claudia A. Staab-Weijnitz, Alexander Dietrich, Robin Kopp, Annette Nicke   +16 more
doaj   +1 more source

AMPK-dependent and independent actions of P2X7 in regulation of mitochondrial and lysosomal functions in microglia

Cell Communication and Signaling, 2018
Background P2X7 is ubiquitously expressed in myeloid cells and regulates the pathophysiology of inflammatory diseases. Since mitochondrial function in microglia is highly associated with microglial functions in controlling neuronal plasticity and brain ...
Ponarulselvam Sekar, Duen-Yi Huang, Shie-Liang Hsieh, Shwu-Fen Chang, Wan-Wan Lin   +4 more
doaj   +1 more source

Understanding exosomes in regenerative dentistry

Periodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad, Anton Sculean, Richard J. Miron   +2 more
wiley   +1 more source

ATP/P2X7 receptor signal aggravates ischemic stroke injury by activating Th17 cells via STAT3/IL-21 pathway

Frontiers in Immunology
BackgroundDuring cerebral ischemia, adenosine triphosphate (ATP) is released into the extracellular matrix from damaged neurons and glial cells, functioning as a danger signal.
Wenying Liu, Wenying Liu, Denghui Li, Mengjie Zhang, Jun Yin, Peng Wang, Paiyu Liu, Zhiqiang Song, Bing Ni, Yanmeng Peng   +9 more
doaj   +1 more source

Tumor‐Regional Immune Microenvironment: A Critical Factor in the Design of Radiotherapy–Immunotherapy Combination Trials

International Journal of Cancer, Volume 159, Issue 8, Page 1857-1872, 15 October 2026.
ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang, Hui Wang, Weiyan Tang, Kai Kang, Kateryna Onyshchenko, Taotao Huang, Dan Liu, Jianxin Xue, You Lu, Gabriele Niedermann, Ren Luo   +10 more
wiley   +1 more source

Adeno‐associated viral vectors encoding anti‐P2X7 nanobodies reduce graft‐versus‐host disease in a humanised mouse model: AAV vectors encoding anti-P2X7 Nbs reduce GVHD

International audienceAbstract Objectives Graft‐versus‐host disease (GVHD) is an inflammatory disorder that arises following allogeneic haematopoietic stem cell transplantation.
Adriouch, Sahil, Sligar, Chloe, Watson, Debbie, Sluyter, Ronald, Hadaya, Janna, H, Elhage, Amal   +5 more
core   +1 more source

P2x7 receptors control demyelination and inflammation in the cuprizone model

Brain, Behavior, & Immunity - Health, 2020
The contribution of P2x7 receptors to multiple sclerosis remains controversial, as both detrimental and beneficial effects resulting from P2x7 receptor loss-of-function have been reported in autoimmune models of the disease.
Ana Bernal-Chico, Andrea Manterola, Raffaela Cipriani, István Katona, Carlos Matute, Susana Mato   +5 more
doaj   +1 more source

P2X7 Interactions and Signaling – Making Head or Tail of It

Frontiers in Molecular Neuroscience, 2019
Extracellular adenine nucleotides play important roles in cell–cell communication and tissue homeostasis. High concentrations of extracellular ATP released by dying cells are sensed as a danger signal by the P2X7 receptor, a non-specific cation channel ...
Robin A. Kopp, Anna Krautloher, Antonio Ramírez-Fernández, A. Nicke   +3 more
semanticscholar   +1 more source

Renal injury in P2X7 knockout rats

P2X7 receptors mediate immune and endothelial cell responses to extracellular ATP. Acute pharmacological blockade increases renal blood flow and filtration rate, suggesting that receptor activation promotes tonic vasoconstriction.
Czopek, Alicja, Mullins, John J, Monaghan, Marie-Louise T, Denby, Laura, Jones, Natalie K, Nespoux, Josselin, Baker, Andrew H, Stewart, Kevin, Menzies, Robert I, Bailey, Matthew   +9 more
core   +1 more source