Results 111 to 120 of about 25,301 (246)
Stem Cell Research & Therapy, 2019 Background Imbalance in bone formation and resorption is a crucial component of the pathological process leading to osteoporosis. Electromagnetic fields (EMFs) have been reported to be beneficial to osteogenesis, although the exact mechanism has not been
Yingchi Zhang +8 more
doaj +1 more source
The FASEB Journal, Volume 40, Issue 17, 15 September 2026.Although purinergic P2Y2 receptor can regulate neural stem cell (NSC) proliferation and neurogenesis in mammals, it is downregulated following spinal cord injury (SCI). It was previously unknown whether this receptor regulates these processes in the more‐regenerative zebrafish model, where the contribution of these responses allows near‐complete ...
Isaac J. Sullivan +7 more
wiley +1 more source
, 2012 The P2X7 receptor is a trimeric ligand-gated ion channel, present in many mammalian species including the canine. P2X7 activation by its natural ligand, extracellular adenosine 5´-triphosphate (ATP), leads to the opening of a large non-selective pore ...
Iman Jalilian (543338)
core +1 more source
P2X7, inflammation and gastrointestinal disease [PDF]
The inflammatory bowel diseases, ulcerative colitis and Crohn's disease are characterised by spontaneously relapsing and remitting inflammation, associated with increased mucosal levels of the inflammatory cytokine, interleukin-1 (IL-1)β.
Stevenson, Diane J.
core +3 more sources
BRET‐Based Approaches for Ion Channels: Emerging Applications and Future Directions
Archiv der Pharmazie, Volume 359, Issue 9, September 2026.Bioluminescence resonance energy transfer (BRET) is a versatile method for studying ligand–protein interactions. Its compatibility with high‐throughput screening and real‐time kinetics has made it widely used in drug discovery. Here, we summarize recent applications of BRET‐based methods for studying ligand binding to ion channels, highlighting key ...
Nadine Kock +6 more
wiley +1 more source
Memorias do Instituto Oswaldo Cruz, 2000 The expression of P2Z/P2X7 purinoceptor in different cell types is well established. This receptor is a member of the ionotropic P2X receptor family, which is composed by seven cloned receptor subtypes (P2X1 - P2X7).
Nihei Oscar Kenji +2 more
doaj
Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology
Molecular Psychiatry, 2020 Scientists and health professionals are exhaustively trying to contain the coronavirus disease 2019 (COVID-19) pandemic by elucidating viral invasion mechanisms, possible drugs to prevent viral infection/replication, and health cares to minimize ...
D. Ribeiro +9 more
semanticscholar +1 more source
Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.Natural product flavonoids have a multi‐target therapeutic intervention effect on osteoarthritis. They promote autophagy and cartilage synthesis while alleviating oxidative stress, inhibiting inflammation, and inhibiting matrix degradation. By restoring OPG/RANKL balance and regulating bone metabolism, these compounds synergistically delay the ...
Haibin Wang +6 more
wiley +1 more source
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.The primary function of statins is to inhibit cholesterol synthesis, which contributes to their antidiabetic effects. However, the majority of the diabetic effects of statins are due to inhibition of isoprenoid synthesis. Atorvastatin, simvastatin and rosuvastatin possess the most pronounced diabetogenic properties. In contrast, lovastatin, fluvastatin,
Ali Nosrati Andevari, Mohsen Koolivand
wiley +1 more source
Integrated Engineering of CAR‐T Cells for Solid Tumours
Cell Proliferation, Volume 59, Issue 9, September 2026.Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang +5 more
wiley +1 more source