Results 131 to 140 of about 13,166 (177)

Expression of Purinergic and Endothelial Activation Markers in Brain Tissue From Fatal Microcephaly Associated With ZIKV. [PDF]

Immun Inflamm Dis
Sousa JR, Batista Ferro G, Vieira Teixeira L, Silva C, Lima L, Neto O, Azevedo R, Chiang JO, Casseb LMN, Filho AJM, Martins LC, Quaresma JAS, Vasconcelos PFDC.   +12 more
europepmc   +1 more source

P2X7 and inflammatory fingerprinting of patients with carotid atherosclerosis and the risk of abdominal aortic aneurysm. [PDF]

Sci Rep
Lombardi M, Spartano L, Ardita V, Valente FBA, Galati N, Castellano R, Chiesa R, Baccellieri D, Foglieni C.   +8 more
europepmc   +1 more source

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The Elusive P2X7 Macropore

Trends in Cell Biology, 2018
ATP, which is released under pathological conditions and is considered a damage-associated molecular pattern (DAMP), activates P2X7 receptors (P2X7Rs), trimeric plasma membrane ion channels selective for small cations. P2X7Rs are partners in NOD-like receptor containing a pyrin (NLRP3) inflammasome activation and promoters of tumor cell growth.
Fritz Markwardt, GÜNTHER Schmalzing, Francesco Di Virgilio   +2 more
exaly   +4 more sources

The P2X7 Receptor

2017
The P2X7 receptor is a trimeric ion channel gated by extracellular adenosine 5'-triphosphate. The receptor is present on an increasing number of different cells types including stem, blood, glial, neural, ocular, bone, dental, exocrine, endothelial, muscle, renal and skin cells.
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Tissue distribution of the P2X7 receptor

Neuropharmacology, 1997
The P2X7 receptor is a bifunctional molecule. The binding of ATP induces within milliseconds the opening of a channel selective for small cations, and within seconds a larger pore opens which allows permeation by molecules as large as propidium dyes (629 Da).
COLLO, Luigia Rinalda, NEIDHART S, KAWASHIMA E, KOSCO VILBOIS M, NORTH RA, BUELL G.   +5 more
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P2X7 receptors in the nervous system

Progress in Neurobiology, 2006
P2X(7) receptors are ligand-gated ion channels, expressed as homo-oligomeric assemblies of individual subunits. They are widely distributed at immunocompetent cells of the central and peripheral nervous system and are believed to be primarily involved in host-defense reaction. However, a growing amount of evidence indicates that their signaling role in
Beáta, Sperlágh, E Sylvester, Vizi, Kerstin, Wirkner, Peter, Illes   +3 more
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Novel P2X7 receptor antagonists

Bioorganic & Medicinal Chemistry Letters, 2003
The synthesis and pharmacological evaluation of a new series of potent P2X(7) receptor antagonists is disclosed. The compounds inhibit BzATP-mediated pore formation in THP-1 cells. The distribution of the P2X(7) receptor in inflammatory cells, most notably the macrophage, mast cell and lymphocyte, suggests that P2X(7) antagonists have a significant ...
L, Alcaraz, A, Baxter, J, Bent, K, Bowers, M, Braddock, D, Cladingboel, D, Donald, M, Fagura, M, Furber, C, Laurent, M, Lawson, M, Mortimore, M, McCormick, N, Roberts, M, Robertson   +14 more
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Effects of antidepressants on P2X7 receptors

Psychiatry Research, 2016
Antidepressants including paroxetine, fluoxetine and desipramine are commonly used for treating depression. P2×7 receptors are member of the P2X family. Recent studies indicate that these receptors may constitute a novel potential target for the treatment of depression. In the present study, we examined the action of these antidepressants on cloned rat
Wei, Wang, Zheng-Hua, Xiang, Chun-Lei, Jiang, Wei-Zhi, Liu, Zhi-Lei, Shang   +4 more
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P2X7 Receptor as a Therapeutic Target

2016
P2X7 receptor is an ATP-gated cation channel that upon agonist interaction leads to cellular influx of Na(+) and Ca(2+) and efflux of K(+). P2X7 is expressed by a wide variety of cells and its activation mediates a large number of biological processes like inflammation, neuromodulation, cell death or cell proliferation and it has been associated to ...
DE MARCHI, Elena, ORIOLI, Elisa, Dal Ben, Diego, ADINOLFI, Elena   +3 more
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