Results 31 to 40 of about 25,301 (246)
Oxidative Medicine and Cellular Longevity, 2021 Osteoarthritis (OA) is an urgent public health problem; however, the underlying causal mechanisms remain unclear, especially in terms of inflammatory mediators in cartilage degradation and chondrocyte imbalance.
Zihao Li +7 more
semanticscholar +1 more source
Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation. [PDF]
PLoS ONE, 2012 P2X7 is a homotrimeric ion channel with two transmembrane domains and a large extracellular ATP-binding domain. It plays a key role in the response of immune cells to danger signals released from cells at sites of inflammation.
Nicole Schwarz +8 more
doaj +1 more source
Irradiation causes senescence, ATP release, and P2X7 receptor isoform switch in glioblastoma
Cell Death and Disease, 2022 Glioblastoma (GBM) is the most lethal brain tumor in adults. Radiation, together with temozolomide is the standard treatment, but nevertheless, relapse occurs in nearly all cases.
M. Zanoni +13 more
semanticscholar +1 more source
Frontiers in Molecular Neuroscience, 2020 The ionotropic ATP-gated P2X7 receptor is an important contributor to inflammatory signaling cascades via the release of Interleukin-1β, as well as having roles in cell death, neuronal plasticity and the release of neurotransmitters.
Giorgia Conte +11 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance The extracellular concentration of adenosine triphosphate (ATP) reaches several hundred micromoles in the inflamed tissues or tumor environment.
Yuta Ryoden, Katsumori Segawa, S. Nagata
semanticscholar +1 more source
Science Advances, 2022 Initial T cell activation is triggered by the formation of highly dynamic, spatiotemporally restricted Ca2+ microdomains. Purinergic signaling is known to be involved in Ca2+ influx in T cells at later stages compared to the initial microdomain formation.
Valerie J. Brock +12 more
semanticscholar +1 more source
تأثیر تمرینات HIIT بر تغییرات Pannexin-1،P2X7، NLRP-1 بافت قلب موشهای صحرایی نر نژاد ویستار مبتلا به دیابت نوع 2 [PDF]
مجله دانشکده پزشکی اصفهانمقاله پژوهشیمقدمه: هدف پژوهش حاضر، مطالعهی تأثیر تمرینات HIIT بر تغییرات سطوح پروتئینهای Pannexin-1، P2X7، NLRP-1 بافت قلب موشهای صحرایی نر نژاد ویستار مبتلا به دیابت نوع 2 میباشد.روشها: در این مطالعه، تعداد 40 سر موش صحرایی نر 8 هفتهای از نژاد ...
یاسمن رفیعی +3 more
doaj +1 more source
Gallic Acid Alleviates Visceral Pain and Depression via Inhibition of P2X7 Receptor
International Journal of Molecular Sciences, 2022 Chronic visceral pain can occur in many disorders, the most common of which is irritable bowel syndrome (IBS). Moreover, depression is a frequent comorbidity of chronic visceral pain.
Lequan Wen +12 more
semanticscholar +1 more source
The relationship between P2X4 and P2X7: a physiologically important interaction? [PDF]
, 2013 Purinergic signaling within the kidney is becoming an important focus in the study of renal health and disease. The effectors of ATP signaling, the P2Y and P2X receptors, are expressed to varying extents in and along the nephron.
Unwin, RJ +18 more
core +1 more source
Administration of P2X7 Receptor Blockers in Oncological Experimental Models
, 2022 The tumor microenvironment is rich in components that strongly influence cancer cell survival. One of the pivotal molecules present at the tumor bed is ATP, which has an essential role in promoting cancer proliferation and metastasis and immune responses
Adinolfi E., Pegoraro A., De Marchi E.
core +1 more source