Results 21 to 30 of about 13,166 (177)

Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody

eLife, 2018
The P2X7 channel is involved in the pathogenesis of various CNS diseases. An increasing number of studies suggest its presence in neurons where its putative functions remain controversial for more than a decade.
Karina Kaczmarek-Hajek, Jiong Zhang, Robin Kopp, Antje Grosche, Björn Rissiek, Anika Saul, Santina Bruzzone, Tobias Engel, Tina Jooss, Anna Krautloher, Stefanie Schuster, Tim Magnus, Christine Stadelmann, Swetlana Sirko, Friedrich Koch-Nolte, Volker Eulenburg, Annette Nicke   +16 more
doaj   +1 more source

P2X7 Receptor Modulation of the Gut Microbiota and the Inflammasome Determines the Severity of Toxoplasma gondii-Induced Ileitis

Biomedicines, 2023
In mice, oral Toxoplasma gondii infection induces severe ileitis. The aim of the present study was to investigate the impact of the P2X7 receptor (P2X7) on the inflammatory response to T. gondii-induced ileitis. Cysts of the ME49 strain of T. gondii were
Aline Cristina Abreu Moreira-Souza, Hayandra Ferreira Nanini, Thuany Prado Rangel, Sthefani Rodrigues Batista da Silva, Beatriz Pêgo Damasceno, Beatriz Elias Ribeiro, Cynthia M. Cascabulho, Fabiano Thompson, Camille Leal, Patrícia Teixeira Santana, Siane Lopes Bittencourt Rosas, Kívia Queiroz de Andrade, Claudia L. Martins Silva, Rossiane Claudia Vommaro, Heitor Siffert Pereira de Souza, Robson Coutinho-Silva   +15 more
doaj   +1 more source

Rod and cone pathway signalling is altered in the P2X7 receptor knock out mouse.

PLoS ONE, 2012
The P2X7 receptor (P2X7-R) is expressed in the retina and brain and has been implicated in neurodegenerative diseases. However, whether it is expressed by neurons and plays a role as a neurotransmitter receptor has been the subject of controversy.
Kirstan A Vessey, Erica L Fletcher
doaj   +1 more source

6-Furopyridine Hexamethylene Amiloride Is a Non-Selective P2X7 Receptor Antagonist

Biomolecules, 2022
P2X7 is an extracellular adenosine 5′-triphopshate (ATP)-gated cation channel present on leukocytes, where its activation induces pro-inflammatory cytokine release and ectodomain shedding of cell surface molecules.
Peter Cuthbertson, Amal Elhage, Dena Al-Rifai, Reece A. Sophocleous, Ross J. Turner, Ashraf Aboelela, Hiwa Majed, Richard S. Bujaroski, Iman Jalilian, Michael J. Kelso, Debbie Watson, Benjamin J. Buckley, Ronald Sluyter   +12 more
doaj   +1 more source

The P2X7 Carboxyl Tail Is a Regulatory Module of P2X7 Receptor Channel Activity [PDF]

Journal of Biological Chemistry, 2008
P2X(7) receptors are ATP-gated cation channels composed of three identical subunits, each having intracellular amino and carboxyl termini and two transmembrane segments connected by a large ectodomain. Within the P2X family, P2X(7) subunits are unique in possessing an extended carboxyl tail.
Daniel, Becker, Ronja, Woltersdorf, Wolfgang, Boldt, Stephan, Schmitz, Ursula, Braam, Günther, Schmalzing, Fritz, Markwardt   +6 more
openaire   +2 more sources

The P2X7 Receptor in Infection and Inflammation [PDF]

Immunity, 2017
Adenosine triphosphate (ATP) accumulates at sites of tissue injury and inflammation. Effects of extracellular ATP are mediated by plasma membrane receptors named P2 receptors (P2Rs). The P2R most involved in inflammation and immunity is the P2X7 receptor (P2X7R), expressed by virtually all cells of innate and adaptive immunity.
DI VIRGILIO, Francesco, Dal Ben, Diego, SARTI, Alba Clara, GIULIANI, Anna Lisa, FALZONI, Simonetta   +4 more
openaire   +4 more sources

The cellular distribution of P2X7, P2Y6, and P2Y12 during or after pilocarpine-induced status epilepticus and literature review

Brain Circulation
BACKGROUND: When a seizure occurs, the distribution of purine receptors in different cell types at various time points remains poorly understood. Our literature review revealed that P2X7, P2Y6, and P2Y12 are expressed in different cells during epilepsy ...
Yue Li, Fengru Tang, Yumin Luo
doaj   +1 more source

Increased P2X7 Receptor Binding Is Associated With Neuroinflammation in Acute but Not Chronic Rodent Models for Parkinson’s Disease

Frontiers in Neuroscience, 2019
The purinergic P2X7 receptor is a key mediator in (neuro)inflammation, a process that is associated with neurodegeneration and excitotoxicity in Parkinson’s disease (PD). Recently, P2X7 imaging has become possible with [11C]JNJ-(54173)717.
Melissa Crabbé, Melissa Crabbé, Anke Van der Perren, Anke Van der Perren, Ilse Bollaerts, Savannah Kounelis, Savannah Kounelis, Veerle Baekelandt, Veerle Baekelandt, Veerle Baekelandt, Guy Bormans, Guy Bormans, Cindy Casteels, Cindy Casteels, Lieve Moons, Lieve Moons, Koen Van Laere, Koen Van Laere   +17 more
doaj   +1 more source

P2X7 mediates ATP-driven invasiveness in prostate cancer cells. [PDF]

PLoS ONE, 2014
The ATP-gated P2X7 has been shown to play an important role in invasiveness and metastasis of some tumors. However, the possible links and underlying mechanisms between P2X7 and prostate cancer have not been elucidated.
Ying Qiu, Wei-Hua Li, Hong-Quan Zhang, Yan Liu, Xin-Xia Tian, Wei-Gang Fang   +5 more
doaj   +1 more source

The P2X7 Receptor: Central Hub of Brain Diseases

Frontiers in Molecular Neuroscience, 2020
The P2X7 receptor is a cation channel activated by high concentrations of adenosine triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming a wide pore that leads to cell death and increased release of ATP into the ...
Roberta Andrejew, Ágatha Oliveira-Giacomelli, Deidiane Elisa Ribeiro, Talita Glaser, Vanessa Fernandes Arnaud-Sampaio, Claudiana Lameu, Henning Ulrich   +6 more
doaj   +1 more source