Results 21 to 30 of about 25,301 (246)
P2X7 receptor activation leads to NLRP3-independent IL-1β release by human macrophages
Cell Communication and Signaling, 2023 Background The purinergic receptor P2X7 plays a crucial role in infection, inflammation, and cell death. It is thought that P2X7 receptor stimulation triggers processing and release of the pro-inflammatory cytokine interleukin (IL)-1β by activation of ...
Judith Bockstiegel +2 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2023 Introduction: Sepsis is defined as a multifactorial debilitating condition with high risks of death. The intense inflammatory response causes deleterious effects on the brain, a condition called sepsis-associated encephalopathy.
Vinicius Alves +17 more
semanticscholar +1 more source
Untangling Macropore Formation and Current Facilitation in P2X7
International Journal of Molecular Sciences, 2023 Macropore formation and current facilitation are intriguing phenomena associated with ATP-gated P2X7 receptors (P2X7). Macropores are large pores formed in the cell membrane that allow the passage of large molecules.
Federico Cevoli +3 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2022 Depression is a common and serious mental disorder. Data on its pathogenesis remain unclear and the options of drug treatments are limited. Here, we explored the role of pyroptosis, a novel pro-inflammatory programmed cell death process, in depression as
Yuhui Chai +8 more
semanticscholar +1 more source
Archives of Medical Science, 2020 Introduction The role of P2X7 in the progression of breast cancer remains unclear; hence, it is necessary to investigate whether the P2X7/NLRP3/caspase 1 signalling pathway is associated with the development of breast cancer.
Xiaolan Yu +6 more
doaj +1 more source
Medicinal research reviews (Print), 2023 The P2X7 receptor is an exceptional member of the P2X purinergic receptor family, with its activation requiring high concentrations of extracellular adenosine 5ʹ‐triphosphate (ATP) that are often associated with tissue damage and inflammation.
Ya-Ling Yin +9 more
semanticscholar +1 more source
The P2X7 Receptor, a Multifaceted Receptor in Alzheimer’s Disease
International Journal of Molecular Sciences, 2023 Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by impaired episodic memory and two pathological lesions: amyloid plaques and neurofibrillary tangles.
Kaitryn E. Ronning +5 more
semanticscholar +1 more source
The P2X7 Receptor in Tumor Immunity [PDF]
Frontiers in Cell and Developmental Biology, 2021 Extracellular adenosine triphosphate (eATP) is a potent mediator of the immune response via stimulation of purinergic P2 receptors. ATP concentration in the extracellular space increases dramatically during tissue damage and eATP acts as a danger-associated molecular pattern (DAMP) to alert innate immune system cells for tissue repair.
Fabio Grassi +2 more
openaire +4 more sources
P2X7 Purinoceptor Affects Ectopic Calcification of Dystrophic Muscles
Frontiers in Pharmacology, 2022 Ectopic calcification (EC) of myofibers is a pathological feature of muscle damage in Duchenne muscular dystrophy (DMD). Mineralisation of muscle tissue occurs concomitantly with macrophage infiltration, suggesting a link between ectopic mineral ...
Robin M. H. Rumney +6 more
doaj +1 more source
Animal Models for the Investigation of P2X7 Receptors
International Journal of Molecular Sciences, 2023 The P2X7 receptor is a trimeric ligand-gated cation channel activated by extracellular adenosine 5′-triphosphate. The study of animals has greatly advanced the investigation of P2X7 and helped to establish the numerous physiological and ...
R. Sluyter +5 more
semanticscholar +1 more source