Results 41 to 50 of about 21,240,958 (197)

Pannexin 1 as a driver of inflammation and ischemia–reperfusion injury [PDF]

Purinergic Signalling, 2021
Pannexin 1 (Panx1) is a ubiquitously expressed protein forming large conductance channels that are central to many distinct inflammation and injury responses. There is accumulating evidence showing ATP released from Panx1 channels, as well as metabolites, provide effective paracrine and autocrine signaling molecules that regulate different elements of ...
Michael Koval, Aleksandra Cwiek, Thomas Carr, Miranda E. Good, Alexander W. Lohman, Brant E. Isakson   +5 more
openaire   +2 more sources

Functional implications of calcium permeability of the channel formed by pannexin 1. [PDF]

, 2006
Although human pannexins (PanX) are homologous to gap junction molecules, their physiological function in vertebrates remains poorly understood. Our results demonstrate that overexpression of PanX1 results in the formation of Ca(2+)-permeable gap ...
Ivanov, Dmitry, V, Panchin, YV, Vanden Abeele, F, Fabien Vanden Abeele, Panchin, Yuri V, Gordienko, D, Yuri V. Panchin, Baranova, AV, Skryma, R, Baranova, Ancha, V, Skryma, Roman, Gordienko, Dmitri, Gabriel Bidaux, Beck, Benjamin, Ivanov, DV, Prevarskaya, N, Ancha V. Baranova, Baranova, Ancha V, Natalia Prevarskaya, Benjamin Beck, Ivanov, Dmitry V, Panchin, Yuri, Ivanov, Dimitri, Prevarskaya, Natalia, Vanden Abeele, Fabien, Bidaux, G, Bidaux, Gabriel, Dmitry V. Ivanov, Beck, B, Panchin, Yuri, V, Roman Skryma, Dmitri Gordienko   +31 more
core   +1 more source

Identification of Pannexins in Rat Nasal Mucosa

Allergy & Rhinology, 2013
Pannexins are a second family of gap-junction proteins in vertebrates, classified as pannexin-1, pannexin-2, and pannexin-3. Pannexin-1 is one of the candidates for channel-mediated ATP release into the extracellular space.
Toyoaki Ohbuchi M.D., Nobusuke Hohchi M.D., Jun-ichi Ohkubo M.D., Koichi Hashida M.D., Hiroki Koizumi M.D., Tetsuro Wakasugi M.D., Fumiko Takenaga M.D., Hideaki Suzuki M.D., Ph.D.   +7 more
doaj   +1 more source

Emerging concepts regarding pannexin 1 in the vasculature [PDF]

Biochemical Society Transactions, 2015
Pannexin channels are newly discovered ATP release channels expressed throughout the body. Pannexin 1 (Panx1) channels have become of great interest as they appear to participate in a multitude of signalling cascades, including regulation of vascular function. Although numerous Panx1 pharmacological inhibitors have been discovered, these inhibitors are
Miranda E, Good, Daniela, Begandt, Leon J, DeLalio, Alexander S, Keller, Marie, Billaud, Brant E, Isakson   +5 more
openaire   +2 more sources

Structural order in Pannexin 1 cytoplasmic domains [PDF]

Channels, 2014
Pannexin 1 forms ion and metabolite permeable hexameric channels with abundant expression in the central nervous system and elsewhere. Although pannexin 1 does not form intercellular channels, a common channel topology and oligomerization state, as well as involvement of the intracellular carboxyl terminal (CT) domain in channel gating, is shared with ...
Gaelle, Spagnol, Paul L, Sorgen, David C, Spray   +2 more
openaire   +2 more sources

Pannexin-1 in silico modeling towards physiological and pathological functioning [PDF]

, 2020
The transmembrane pore protein Pannexin-1 (Panx1) forms channels allowing the release of purine nucleotides and participates in processes related to purinergic signaling, including blood pressure regulation, apoptotic cell clearance, and neuropathic pain.

core   +1 more source

Is the Pannexin-1 channel a mechanism underlying hypertension in humans? A translational study of human hypertension [PDF]

, 2022
Background: In preclinical models, the pannexin-1 channel has been shown to be involved in blood pressure regulation through an effect on peripheral vascular resistance. Pannexin-1 releases ATP, which can activate constrictive purinergic receptors on the
Gliemann, Lasse, Ehlers, Thomas Svare, Tamariz-Ellemann, Andrea, Hellsten, Ylva, Møller, Sophie, Hansen, Camilla Collin   +5 more
core   +1 more source

Single-cell dynamics of pannexin-1-facilitated programmed ATP loss during apoptosis

eLife, 2020
ATP is essential for all living cells. However, how dead cells lose ATP has not been well investigated. In this study, we developed new FRET biosensors for dual imaging of intracellular ATP level and caspase-3 activity in single apoptotic cultured human ...
Hiromi Imamura, Shuichiro Sakamoto, Tomoki Yoshida, Yusuke Matsui, Silvia Penuela, Dale W Laird, Shin Mizukami, Kazuya Kikuchi, Akira Kakizuka   +8 more
doaj   +1 more source

Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma. [PDF]

FEBS J
Abstract In this study, we explored the intricate relationship between Pannexin 1 (PANX1) and the Hippo signaling pathway effector, Yes-associated protein (YAP). Analysis of The Cancer Genome Atlas (TCGA) data revealed a significant positive correlation between PANX1 mRNA and core Hippo components, YAP, TAZ, and Hippo scaffold, IQGAP1 ...
Sayedyahossein S, Huang K, Zhang C, Karimi M, Bahmani M, O'Donnell BL, Wakefield B, Li Z, Johnston D, Leighton SE, Huver MS, Dagnino L, Sacks DB, Penuela S.   +13 more
europepmc   +4 more sources

Distinct Molecular Mechanisms Underlying Potassium Efflux for NLRP3 Inflammasome Activation

Frontiers in Immunology, 2020
The NLRP3 inflammasome is a core component of innate immunity, and dysregulation of NLRP3 inflammasome involves developing autoimmune, metabolic, and neurodegenerative diseases.
Ziwei Xu, Zi-mo Chen, Xiaoyan Wu, Linjie Zhang, Ying Cao, Pingzheng Zhou   +5 more
doaj   +1 more source