Results 41 to 50 of about 29,697,217 (152)

Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents [PDF]

, 2017
The release of ATP from spinal microglia via pannexin-1 channels is required for withdrawal symptoms after termination of chronic opioid treatment in rodents, and pharmacological blockade of pannexin-1 channels reduces the severity of withdrawal without ...
Burma, Nicole E, Baimel, Corey, Bonin, Robert P, De Koninck, Yves, Patrick L Stemkowski, Baimoukhametova, Dinara, Corey Baimel, Gerald W Zamponi, Mousseau, Michael, Yves De Koninck, Jaideep S Bains, Heather Leduc-Pessah, Antle, Michael C, Stephanie L Borgland, DeKoninck, Yves, Jhenkruthi Vijaya Shankara, Michael C Antle, Zoe F Cairncross, Shankara, Jhenkruthi Vijaya, Yves DeKoninck, Tuan Trang, Nicole E Burma, Borgland, Stephanie L, Robert P Bonin, Michael Mousseau, Trang, Tuan, Cairncross, Zoe F, Cahill, Catherine M, Catherine M Cahill, Stemkowski, Patrick L, Bains, Jaideep S, Dinara Baimoukhametova, Leduc-Pessah, Heather, Zamponi, Gerald W   +33 more
core   +1 more source

Extracellular vesicles regulate gap junction-mediated intercellular communication and HIV-1 infection of human neural progenitor cells

Neurobiology of Disease, 2021
Human immunodeficiency virus-1 (HIV-1) has been shown to cross the blood-brain barrier and cause HIV-associated neurocognitive disorders (HAND) through a process that may involve direct or indirect interactions with the central nervous system (CNS) cells
Hyung Joon Cho, Martina Velichkovska, Nicolette Schurhoff, Ibolya E. András, Michal Toborek   +4 more
doaj   +1 more source

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Differential profiles of pannexin-1 in diabetes and wound healing during aging [PDF]

, 2023
Diabetes mellitus is a very common disease with a global prevalence of 470 million in 2017. Diabetics have a higher risk of developing a number of complications in the cornea including dysfunctional wound healing, many of which currently have risky or ...
Machen, Cody
core   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Ubiquitination and Proteasomal Regulation of Pannexin 1 and Pannexin 3

, 2020
Pannexin 1 (PANX1) and Pannexin 3 (PANX3) are single-membrane channel glycoproteins that allow for communication between the cell and its environment to regulate cellular differentiation, proliferation, and apoptosis.
Blinder, Anna
core   +1 more source

Pannexin 1 inhibition delays maturation and improves development of Bos taurus oocytes

Journal of Ovarian Research, 2020
Background Intercellular exchange between the oocyte and its surrounding cells within the follicular environment is critical for oocyte maturation and subsequent development.
Zachary Timothy Dye, Lauren Virginia Rutledge, Silvia Penuela, Paul William Dyce   +3 more
doaj   +1 more source

Mechanistic insights into severe pulmonary inflammation caused by silica stimulation: The role of macrophage pyroptosis

Ecotoxicology and Environmental Safety, 2023
Respirable silica dust is a common hazard faced by occupational workers and prolonged exposure to this dust can lead to pulmonary inflammation, fibrosis and, in severe cases, silicosis.
Lin Zhang, Jiaqi Tian, Lan Ma, Shuyin Duan   +3 more
doaj   +1 more source

Immune cells in the pathogenesis of abdominal aortic aneurysm: Roles, regulation and targeted interventions

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review provides a comprehensive overview of how macrophages, neutrophils, T cells and other immune cells infiltrate the aortic wall, undergo phenotypic shifts and interact with one another in abdominal aortic aneurysm (AAA). Background Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease with no approved clinical drugs. Immune
Junqi Peng, Hanqing Zhang, Yun Wu, Song Chen   +3 more
wiley   +1 more source

Exploring the Impact of Urolithins A and B on Muscle Health: A Transcriptomic Analysis in Human Myotubes

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Urolithin A (UA) and urolithin B (UB) are gut microbiota‐derived metabolites of ellagitannins reported to influence mitochondrial function, inflammation and muscle metabolism. Their comparative transcriptomic effects in human skeletal muscle cells remain undefined.
Yves Henrotin, Antoine Florin, Christelle Sanchez, Prescilia Centonze, Tiago Pinto Coelho, Sophie Bekisz, Jean‐Emile Dubuc, Olivier Galand, Cécile Lambert   +8 more
wiley   +1 more source