Exercise training lowers arterial blood pressure independently of Pannexin 1 in men with essential hypertension [PDF]
, 2022 Introduction: Regular exercise training reduces arterial blood pressure but the underlying mechanisms are unclear. Here, we evaluated the potential involvement of Pannexin 1, an ATP releasing channel, in the blood pressure-reducing effect of training ...
Gliemann, Lasse +21 more
core +1 more source
Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents [PDF]
, 2017 The release of ATP from spinal microglia via pannexin-1 channels is required for withdrawal symptoms after termination of chronic opioid treatment in rodents, and pharmacological blockade of pannexin-1 channels reduces the severity of withdrawal without ...
Burma, Nicole E +33 more
core +1 more source
Extracellular ATP hydrolysis inhibits synaptic transmission by increasing ph buffering in the synaptic cleft. [PDF]
PLoS Biology, 2014 Neuronal computations strongly depend on inhibitory interactions. One such example occurs at the first retinal synapse, where horizontal cells inhibit photoreceptors.
Rozan Vroman +6 more
doaj +1 more source
A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP [PDF]
, 2009 Pannexin 1 forms a large membrane channel that, based on its biophysical properties and its expression pattern, is a prime candidate to represent an ATP release channel. Pannexin 1 channel activity is potentially deleterious for cells as indicated by its
Dahl, Gerhard, Qiu, Feng
core +1 more source
Pannexin‐1 in the CNS: Emerging concepts in health and disease [PDF]
Journal of Neurochemistry, 2020 AbstractPannexin‐1 (Panx1) is a large pore membrane channel with unique conduction properties ranging from non‐selective ion permeability to the extracellular release of signalling molecules. The release of ATP by Panx1 has been particularly well‐characterized with implications in purine signalling across a variety of biological contexts.
Albert K. Yeung +2 more
openaire +2 more sources
Pannexin-1 as a potentiator of ligand-gated receptor signaling [PDF]
Channels, 2014 Pannexins are a class of plasma membrane spanning proteins that presumably form a hexameric, non-selective ion channel. Although similar in secondary structure to the connexins, pannexins notably do not form endogenous gap junctions and act as bona fide ion channels.
Isakson, Brant E, Thompson, Roger J
openaire +2 more sources
Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation [PDF]
Journal of Cell Science, 2010 Pannexin (Panx) 1 and Panx3 are integral membrane proteins that share some sequence homology with the innexin family of invertebrate gap junctions. They are expressed in mammalian skin. Pannexins have been reported to form functional mechanosensitive single-membrane channels, but their importance in regulating cellular function is poorly understood. In
Steven J, Celetti +5 more
openaire +2 more sources
Die kardiale Phänotypisierung von TASK-1- und Pannexin-1-defizienten Mäusen [PDF]
, 2016 Erkrankungen des Herz-Kreislauf-Systems stellen weltweit die häufigste Todesursache dar. 40 % der Todesfälle in Deutschland lassen sich darauf zurückführen.
Schulte, Stella
core +2 more sources
Taking a close look at a large-pore channel
eLife, 2020 The structure of pannexin 1, a channel protein with a large pore, has been determined for the first time.
Pablo S Gaete, Jorge E Contreras
doaj +1 more source
Neurodegeneration in Multiple Sclerosis: The Role of Nrf2-Dependent Pathways
Antioxidants, 2022 Multiple sclerosis (MS) encompasses a chronic, irreversible, and predominantly immune-mediated disease of the central nervous system that leads to axonal degeneration, neuronal death, and several neurological symptoms.
Paloma P. Maldonado +5 more
doaj +1 more source