Results 61 to 70 of about 21,240,958 (197)
Pannexin-1 Deficiency Decreases Epileptic Activity in Mice [PDF]
International Journal of Molecular Sciences, 2020 Objective: Pannexin-1 (Panx1) is suspected of having a critical role in modulating neuronal excitability and acute neurological insults. Herein, we assess the changes in behavioral and electrophysiological markers of excitability associated with Panx1 via three distinct models of epilepsy.
Mark S. Aquilino +6 more
openaire +3 more sources
Differential profiles of pannexin-1 in diabetes and wound healing during aging [PDF]
, 2023 Diabetes mellitus is a very common disease with a global prevalence of 470 million in 2017. Diabetics have a higher risk of developing a number of complications in the cornea including dysfunctional wound healing, many of which currently have risky or ...
Machen, Cody
core
Frontiers in Molecular Neuroscience, 2017 Background: Accumulating evidence suggests that neuroinflammation plays a critical role in early brain injury after subarachnoid hemorrhage (SAH). Pannexin-1 channels, as a member of gap junction proteins located on the plasma membrane, releases ATP ...
Ling-Yun Wu +13 more
doaj +1 more source
International Journal of Oral Science, 2023 Severe muscle injury is hard to heal and always results in a poor prognosis. Recent studies found that extracellular vesicle-based therapy has promising prospects for regeneration medicine, however, whether extracellular vesicles have therapeutic effects
Qingyuan Ye +13 more
doaj +1 more source
Activation of pannexin-1 mediates triglyceride-induced macrophage cell death. [PDF]
, 2020 The accumulation of triglycerides (TGs) in macrophages induces cell death, a risk factor in the pathogenesis of atherosclerosis. We had previously reported that TG-induced macrophage death is triggered by caspase-1 and -2, therefore we investigated the ...
Kim, Sung +3 more
core +1 more source
Pannexin-1 couples to maitotoxin and nigericin- induced il-1β release through a dye-uptake independent pathway [PDF]
, 2007 ©2007. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepte version of a Published Work that appeared in final form in Journal of Biological Chemistry.
Pelegrin, Pablo, Surprenant, Annmarie
core +3 more sources
Pannexin-1 and other anion channels in platelets and megakaryocytes [PDF]
, 2015 Platelet ion channels are essential for Ca2+-influx, maintaining the resting membrane potential and cell volume regulation. Cation channels have been widely studied but few reports of platelet anion channels exist.
Kirk Allen Taylor (7667516)
core
British Journal of Clinical Pharmacology, EarlyView.Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili +6 more
wiley +1 more source
Source_file.xlsxCryo-EM structures of Pannexin 1 and 3 reveal differences among Pannexin isoforms [PDF]
Pannexins are single-membrane large-pore ion channels that releases ions and ATP upon activation. Three isoforms of pannexins 1, 2, and 3, perform diverse cellular roles and differ in their pore lining residues.
Aravind Penmatsa (18020539) +2 more
core +1 more source
Measuring the amount of the channel protein pannexin 1 across neuronal development [PDF]
, 2022 My Presentation is on Pannexin 1 an ATP channel protein in the brain. I have analyzed both the theoretical side as well as the practical side of this protein.
Irwin, Eamonn
core +1 more source