Results 81 to 90 of about 29,697,217 (152)

تأثیر تمرینات HIIT بر تغییرات Pannexin-1،P2X7، NLRP-1 بافت قلب موش‌های صحرایی نر نژاد ویستار مبتلا به دیابت نوع 2 [PDF]

مجله دانشکده پزشکی اصفهان
مقاله پژوهشیمقدمه: هدف پژوهش حاضر، مطالعه‌ی تأثیر تمرینات HIIT بر تغییرات سطوح پروتئین‌های Pannexin-1، P2X7، NLRP-1 بافت قلب موش‌های صحرایی نر نژاد ویستار مبتلا به دیابت نوع 2 می‌باشد.روش‌ها: در این مطالعه، تعداد 40 سر موش صحرایی نر 8 هفته‌ای از نژاد ...
یاسمن رفیعی, علی اکبر علی زاده, سعید شاکریان, امیرحسین رمضانی احمدی   +3 more
doaj   +1 more source

The two faces of pannexins: new roles in inflammation and repair

Journal of Inflammation Research, 2018
Helen P Makarenkova,1 Sameer B Shah,2,3 Valery I Shestopalov4–6 1Department of Molecular Medicine, Scripps Research Institute, 2Departments of Orthopaedic Surgery and Bioengineering, University of California, 3Research Division, Veterans Affairs ...
Makarenkova HP, Shah SB, Shestopalov VI
doaj  

ATP-release pannexin channels are gated by lysophospholipids

eLife
In addition to its role as cellular energy currency, adenosine triphosphate (ATP) serves as an extracellular messenger that mediates diverse cell-to-cell communication.
Erik Henze, Russell N Burkhardt, Bennett William Fox, Tyler J Schwertfeger, Eric Gelsleichter, Kevin Michalski, Lydia Kramer, Margret Lenfest, Jordyn M Boesch, Hening Lin, Frank C Schroeder, Toshimitsu Kawate   +11 more
doaj   +1 more source

The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes

, 2009
The inflammasome is a multiprotein complex involved in innate immunity. Activation of the inflammasome causes the processing and release of the cytokines interleukins 1β and 18. In primary macrophages, potassium ion flux and the membrane channel pannexin
Locovei, Silviu, Dahl, Gerhard, Silverman, William R, de Rivero Vaccari, Juan Pablo, Scemes, Eliana, Qiu, Feng, Carlsson, Steven K, Keane, Robert W   +7 more
core   +1 more source

Source_file.xlsxCryo-EM structures of Pannexin 1 and 3 reveal differences among Pannexin isoforms

Pannexins are single-membrane large-pore ion channels that releases ions and ATP upon activation. Three isoforms of pannexins 1, 2, and 3, perform diverse cellular roles and differ in their pore lining residues.
Aravind Penmatsa (18020539), ASHISH APOTIKAR (18060037), NAZIA HUSSAIN (18060036)   +2 more
core   +1 more source

Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling [PDF]

, 2007
SummaryCryopyrin is essential for caspase-1 activation triggered by Toll-like receptor (TLR) ligands in the presence of adenosine triphosphate (ATP). However, the events linking bacterial products and ATP to cryopyrin remain unclear.
Kim, Yun-Gi, Kanneganti, Thirumala-Devi, Luigi Franchi, Yun-Gi Kim, Park, Jong-Hwan, Vandenabeele, PeterCA05WE140019790145118010005653840000-0002-6669-8822F4243658-F0ED-11E1-A9DE-61C894A0A6B4, KIM, YG, KANNEGANTI, TD, PARK, JH, NUNEZ, G, Chen, Grace, CHEN, G, Gabriel Núñez, Jong-Hwan Park, FRANCHI, L, Lamkanfi, MohamedGE350019960063828010015031530000-0002-6350-72691E5D1DC2-F0EE-11E1-A9DE-61C894A0A6B4, Franchi, Luigi, Mohamed Lamkanfi, Vandenabeele, Peter, Grace Chen, Núñez, Gabriel, Thirumala-Devi Kanneganti, Lamkanfi, Mohamed, Peter Vandenabeele   +23 more
core   +1 more source

Pannexin 1 sustains the electrophysiological responsiveness of retinal ganglion cells

Scientific Reports, 2018
Pannexin 1 (Panx1) forms ATP-permeable membrane channels that play a key role in purinergic signaling in the nervous system in both normal and pathological conditions.
Galina Dvoriantchikova, Alexey Pronin, Sarah Kurtenbach, Abduqodir Toychiev, Tsung-Han Chou, Christopher W. Yee, Breanne Prindeville, Junior Tayou, Vittorio Porciatti, Botir T. Sagdullaev, Vladlen Z. Slepak, Valery I. Shestopalov   +11 more
doaj   +1 more source

Differential role of the pannexin-1/ATP/P2X7 axis in IL-1β release by human monocytes [PDF]

, 2017
IL - 1 β release is integral to the innate immune system. The release of mature IL - 1 β depends on two regulated events; (i) the de novo induction of pro - IL - 1 β , generally via NF κ B - depend ent transduction pathways and (ii) the assembly ...
Mark J. Paul‐Clark, Paul-Clark, Mark J., Mitchell, JA, Kirkby, NS, William R. Wright, Parzych, K, Wright, WR, Parzych, Katarzyna, Paul-Clark, M, Katarzyna Parzych, Zetterqvist, A, Jane A. Mitchell, Wright, William R., Kirkby, Nicholas S, Zetterqvist, Anna V., Mitchell, Jane A, Anna V. Zetterqvist, Nicholas S. Kirkby   +17 more
core   +1 more source

Low levels of pannexin‐1 in Behçet’s syndrome

, 2019
Objective Behcet's syndrome (BS) is a chronic, multisystemic and inflammatory syndrome. In our study, we aimed to compare the initiator, effector and inflammatory caspases and pannexin channel protein, which is thought to have an activity in inflammation,
DOĞAN, HALEF OKAN, Ali Şahin, Abdullah İlhan, Mehtap Şahin, ŞAHİN, ALİ, Halef Okan Doğan, Mehmet Emin Derin, Ilhan, Abdullah, Derin, Mehmet Emin, Sahin, MEHTAP   +9 more
core   +2 more sources

Pannexin-1 Is Required for ATP Release during Apoptosis but Not for Inflammasome Activation

, 2011
Apoptotic cell death is important for embryonic development, immune cell homeostasis, and pathogen elimination. Innate immune cells also undergo a very rapid form of cell death termed pyroptosis after activating the protease caspase-1.
Shahram Misaghi, James E. Cupp, David Hackos, Salina Louie, Yan Qu, Vishva M. Dixit, Laurie L. Gilmour, George R. Dubyak, Kim Newton   +8 more
core   +1 more source