Results 91 to 100 of about 21,240,958 (197)

The emerging Pannexin 1 signalome: a new nexus revealed?

Frontiers in Cellular Neuroscience, 2014
Pannexins (Panxs) are a family of single-membrane, large-pore ion and metabolite permeable channels. Of the three Panx proteins, Panx1 has been most extensively studied, and has recently emerged as an exciting, clinically relevant target in many ...
Leigh Elizabeth Wicki-Stordeur, Leigh Anne eSwayne, Leigh Anne eSwayne, Leigh Anne eSwayne, Leigh Anne eSwayne   +4 more
doaj   +1 more source

Mind the gap: connexins and pannexins in platelet function

Platelets, 2021
Connexins are a family of gap junction forming proteins widely expressed by mammalian cells. They assemble into hexameric hemichannels, which can either function independently or dock with opposing hemichannels on apposite cells, forming a gap junction ...
Kirk a Taylor, Gemma Little, Jonathan M. Gibbins   +2 more
doaj   +1 more source

Multifaceted Role of Extracellular Vesicles: Intercellular Messengers to Therapeutic Applications: A Narrative Review

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Extracellular vesicles (EVs) are nanoscale carriers, including exosomes, microvesicles, and apoptotic bodies, that mediate intercellular communication by transporting proteins, nucleic acids, lipids, and metabolites. They regulate immunity, tissue repair, and cell differentiation.
Kajal Kamra, Satya Kumar Lalam, Shefali Srivastava, Madan Kumar Arumugam, Lokesh Kumar Boopathy, Simran Takkar, Zhiqiu Xia, Sabarinath Peruvemba Subramanian   +7 more
wiley   +1 more source

Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling [PDF]

, 2007
SummaryCryopyrin is essential for caspase-1 activation triggered by Toll-like receptor (TLR) ligands in the presence of adenosine triphosphate (ATP). However, the events linking bacterial products and ATP to cryopyrin remain unclear.
Kim, Yun-Gi, Kanneganti, Thirumala-Devi, Luigi Franchi, Yun-Gi Kim, Park, Jong-Hwan, Vandenabeele, PeterCA05WE140019790145118010005653840000-0002-6669-8822F4243658-F0ED-11E1-A9DE-61C894A0A6B4, KIM, YG, KANNEGANTI, TD, PARK, JH, NUNEZ, G, Chen, Grace, CHEN, G, Gabriel Núñez, Jong-Hwan Park, FRANCHI, L, Lamkanfi, MohamedGE350019960063828010015031530000-0002-6350-72691E5D1DC2-F0EE-11E1-A9DE-61C894A0A6B4, Franchi, Luigi, Mohamed Lamkanfi, Vandenabeele, Peter, Grace Chen, Núñez, Gabriel, Thirumala-Devi Kanneganti, Lamkanfi, Mohamed, Peter Vandenabeele   +23 more
core   +1 more source

Pannexin 1 Regulates Bidirectional Hippocampal Synaptic Plasticity in Adult Mice

Frontiers in Cellular Neuroscience, 2014
The threshold for bidirectional modification of synaptic plasticity is known to be controlled by several factors, including the balance between protein phosphorylation and dephosphorylation, postsynaptic free Ca2+ concentration and NMDA receptor (NMDAR ...
Alvaro O. Ardiles, Carolina eFlores-Muñoz, Gabriela eToro-Ayala, Ana María Cárdenas, Adrian G Palacios, Pablo eMuñoz, Pablo eMuñoz, Marco eFuenzalida, Juan C Saez, Juan C Saez, Agustin D Martinez   +10 more
doaj   +1 more source

Exacerbated ATP transmission in the carotid body is linked to glomus cell expansion in spontaneously hypertensive rats

The Journal of Physiology, Volume 604, Issue 12, Page 4678-4706, 15 June 2026.
Abstract figure legend Exacerbated ATP signalling in the carotid body (CB) of spontaneously hypertensive rats (SHRs) arises from expansion of the chemosensory glomus cell compartment and reduced extracellular ATP metabolism, leading to increased purinergic drive.
Igor S. A. Felippe, Audrys Pauza, Olivia M. S. Gold, Xin Shen, Fernanda Brognara, Rosanna Roberts Nonu, Dylan K. Pen, Aabharika Bose, Emma N. Bardsley, Anna P. Ponnampalam, Davi J. A. Moraes, Julian F. R. Paton   +11 more
wiley   +1 more source

Pannexin 1 deficiency can induce hearing loss [PDF]

Biochemical and Biophysical Research Communications, 2015
Gap junctions play a critical role in hearing. Connexin gap junction gene mutations can induce a high incidence of hearing loss. Pannexin (Panx) gene also encodes gap junction proteins in vertebrates. Panx1 is a predominant pannexin isoform and has extensive expression in the cochlea.
Hong-Bo, Zhao, Yan, Zhu, Chun, Liang, Jin, Chen   +3 more
openaire   +2 more sources

Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium [PDF]

, 2006
The ability for long-range communication through intercellular calcium waves is inherent to cells of many tissues. A dual propagation mode for these waves includes passage of IP3 through gap junctions as well as an extracellular pathway involving ATP ...
Locovei, Silviu, Wang, Junjie, Dahl, Gerhard   +2 more
core   +1 more source

The 3‐Hit Metabolic Signaling Model for Autism Spectrum Disorder: A Summary

Autism Research, Volume 19, Issue 5, May 2026.
ABSTRACT Autism spectrum disorder (ASD) is a highly heritable yet environmentally sensitive neurodevelopmental condition whose biological heterogeneity has resisted a unifying causal explanation for over 100 years. The 3‐hit metabolic signaling model proposes that ASD arises from abnormal persistence of an evolutionarily conserved stress‐response ...
Robert K. Naviaux
wiley   +1 more source

Regulation of Pannexin 1 Channels by ATP [PDF]

, 2010
Pannexins represent a recently discovered second family of gap junction proteins in vertebrates. However, instead of forming intercellular gap junction channels like connexins, pannexins operate as unpaired pannexons, allowing the flux of molecules from ...
Qiu, Feng
core