Results 111 to 120 of about 21,240,958 (197)

Blockade of Pannexin-1 Channels and Purinergic P2X7 Receptors Shows Protective Effects Against Cytokines-Induced Colitis of Human Colonic Mucosa

Frontiers in Pharmacology, 2018
Introduction: The pannexin-1 (Panx1) channels are found in many cell types, and ATP released from these channels can act on nearby cells activating purinergic P2X7 receptors (P2X7R) which lead to inflammation.
Erica F. Diezmos, Irit Markus, D. S. Perera, Steven Gan, Li Zhang, Shaun L. Sandow, Shaun L. Sandow, Paul P. Bertrand, Paul P. Bertrand, Lu Liu   +9 more
doaj   +1 more source

Small Cell Lung Cancer Establishes a Metabolic Autocrine Mechanism Through Active Extracellular ATP Transport

Cancer Science, Volume 117, Issue 5, Page 1333-1345, May 2026.
Small cell lung cancer (SCLC) actively exports ATP through PANX1 channels, triggering P2RX7‐mediated autocrine signaling and promoting tumor proliferation. Inhibition of PANX1 or P2RX7 disrupts this loop and suppresses tumor growth. ABSTRACT Small cell lung cancer (SCLC) is an aggressive malignancy with a 5‐year survival rate of less than 7%.
Takeshi Tsuruda, Manabu Kodama, Keiichi I. Nakayama   +2 more
wiley   +1 more source

Pannexin 1 is the conduit for low oxygen tension-induced ATP release from human erythrocytes [PDF]

, 2010
Erythrocytes release ATP in response to exposure to the physiological stimulus of lowered oxygen (O2) tension as well as pharmacological activation of the prostacyclin receptor (IPR).
Terrance M. Egan, Elizabeth A. Bowles, Meera Sridharan, Alan H. Stephenson, Randy S. Sprague, Mary L. Ellsworth, Shaquria P. Adderley   +6 more
core   +1 more source

ATP-release pannexin channels are gated by lysophospholipids

eLife
In addition to its role as cellular energy currency, adenosine triphosphate (ATP) serves as an extracellular messenger that mediates diverse cell-to-cell communication.
Erik Henze, Russell N Burkhardt, Bennett William Fox, Tyler J Schwertfeger, Eric Gelsleichter, Kevin Michalski, Lydia Kramer, Margret Lenfest, Jordyn M Boesch, Hening Lin, Frank C Schroeder, Toshimitsu Kawate   +11 more
doaj   +1 more source

Baicalin inhibited PANX-1/P2Y6 signaling pathway activation in porcine aortic vascular endothelial cells infected by Glaesserella parasuis

Heliyon
Glaesserella parasuis can induce endothelial barrier damage in piglets, although the mechanism by which this pathogen triggers inflammatory damage remains unclear. Baicalin possesses anti-inflammatory and anti-oxidant activities.
Shulin Fu, Xinyue Tian, Chun Peng, Dan Zhang, Linglu Zhou, Yuzhen Yuan, Jing He, Ling Guo, Yinsheng Qiu, Chun Ye, Yu Liu, Bingbing Zong   +11 more
doaj   +1 more source

تأثیر تمرینات HIIT بر تغییرات Pannexin-1،P2X7، NLRP-1 بافت قلب موش‌های صحرایی نر نژاد ویستار مبتلا به دیابت نوع 2 [PDF]

مجله دانشکده پزشکی اصفهان
مقاله پژوهشیمقدمه: هدف پژوهش حاضر، مطالعه‌ی تأثیر تمرینات HIIT بر تغییرات سطوح پروتئین‌های Pannexin-1، P2X7، NLRP-1 بافت قلب موش‌های صحرایی نر نژاد ویستار مبتلا به دیابت نوع 2 می‌باشد.روش‌ها: در این مطالعه، تعداد 40 سر موش صحرایی نر 8 هفته‌ای از نژاد ...
یاسمن رفیعی, علی اکبر علی زاده, سعید شاکریان, امیرحسین رمضانی احمدی   +3 more
doaj   +1 more source

The two faces of pannexins: new roles in inflammation and repair

Journal of Inflammation Research, 2018
Helen P Makarenkova,1 Sameer B Shah,2,3 Valery I Shestopalov4–6 1Department of Molecular Medicine, Scripps Research Institute, 2Departments of Orthopaedic Surgery and Bioengineering, University of California, 3Research Division, Veterans Affairs ...
Makarenkova HP, Shah SB, Shestopalov VI
doaj  

MECHANISTIC AND STRUCTURAL STUDIES OF PANNEXIN CHANNELS [PDF]

, 2018
Pannexin channels are a family of recently discovered membrane proteins found in nearly every tissue of the human body. These channels have been classified as large ‘pore forming’ proteins which, when activated, create a passageway through the cell ...
Michalski, Kevin
core   +1 more source

The role of pannexin 1 in the purinergic regulation of synaptic transmission in mouse motor synapses [PDF]

, 2017
The role of pannexin 1 in the release to the extracellular space of ATP/adenosine modulating the acetylcholine (ACh) secretion was studied in mouse diaphragm motor synapses. Using neuromuscular preparations obtained from wild-type and pannexin-1 knockout
A. E. Gaydukov, V. I. Shestopalov, Shestopalov, V, Gaydukov, A, A. S. Miteva, O. P. Balezina, Miteva, A, Balezina, O   +7 more
core   +1 more source

Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation [PDF]

, 2019
Apoptosis can promote inflammation by triggering activation of the NLRP3 inflammasome (NLR family, pyrin domain containing 3). However, the molecular mechanisms regulating these processes are ill-defined.
Broz, P., Kaiwen W. Chen, Chen, K.W., Demarco, B., Benjamin Demarco, Petr Broz   +5 more
core   +1 more source