Results 101 to 110 of about 21,240,958 (197)

Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Adenosine, as a key metabolic and neurotransmitter in the brain, has become an important therapeutic target for improving the efficacy of immunotherapy for stroke. However, gaps in knowledge about its metabolic pathways have become a key factor limiting its clinical translation.
Shu Zhu, Shanshan Zhong, Xiaoru Lin, Chuansheng Zhao, Yugang Li   +4 more
wiley   +1 more source

Physiological mechanisms for the modulation of pannexin 1 channel activity

The Journal of Physiology, 2012
Abstract It is widely recognized that ATP, along with other nucleotides, subserves important intercellular signalling processes. Among various nucleotide release mechanisms, the relatively recently identified pannexin 1 (Panx1) channel is gaining prominence by virtue of its ability to support nucleotide permeation and release in a variety of different ...
Joanna K, Sandilos, Douglas A, Bayliss
openaire   +3 more sources

Chemotherapeutic Drugs Induce ATP Release via Caspase-gated Pannexin-1 Channels and a Caspase/Pannexin-1-independent Mechanism [PDF]

Journal of Biological Chemistry, 2014
Anti-tumor immune responses have been linked to the regulated release of ATP from apoptotic cancer cells to engage P2 purinergic receptor signaling cascades in nearby leukocytes. We used the Jurkat T cell acute lymphocytic leukemia model to characterize the role of pannexin-1 (Panx1) channels in the release of nucleotides during chemotherapeutic drug ...
Andrea, Boyd-Tressler, Silvia, Penuela, Dale W, Laird, George R, Dubyak   +3 more
openaire   +2 more sources

Splice-variants of the P2X7 receptor reveal differential agonist-dependence and functional coupling with pannexin-1 [PDF]

, 2012
P2X7 receptors function as ATP-gated cation channels but also interact with other proteins as part of a larger signalling complex to mediate a variety of downstream responses that are dependent upon the cell type in which they are expressed.
Xu, Xing Jian, Boumechache, Miyyada, Dariusz C. Gorecki, Viola Marschall (5769809), Xing Jian Xu, Gorecki, Dariusz C., Viola Marschall, Miyyada Boumechache (16208756), Xu, Xian Jian, Marianela Masin (12653538), Lucy E Robinson (16208738), Murrell-Lagnado, Ruth D., Dariusz C Gorecki (16208759), Marschall, Viola, Marschall, V., Boumechache, M., Gorecki, Darek, Robinson, L., Robinson, Lucy E., Murrell-Lagnado, R., Ruth Murrell-Lagnado, Marianela Masin, Masin, Marianela, Miyyada Boumechache, Lucy E. Robinson, Ruth Murrell-Lagnado (4461403), Masin, M., Xing Jian Xu (16208753)   +27 more
core   +1 more source

Glucose metabolic reprogramming as a driver of immunosuppression in the tumour microenvironment

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
Glucose metabolic reprogramming is a central driver of immunosuppression in the tumour microenvironment, orchestrating immune dysfunction through multiple interconnected mechanisms. Glucose competition establishes a selective bioenergetic hierarchy that constrains antitumour immunity, whereas lactate accumulation and its reciprocal crosstalk with ...
Yang Wang, Yijun Lu, Jian Zhou, Xinrong Yang   +3 more
wiley   +1 more source

Pannexin-1 in Human Lymphatic Endothelial Cells Regulates Lymphangiogenesis [PDF]

, 2018
International audienceThe molecular mechanisms governing the formation of lymphatic vasculature are notyet well understood. Pannexins are transmembrane proteins that form channels which allow fordiffusion of ions and small molecules (
Clarhaut, Jonathan, Claire Simonneau, Mesnil, Marc, Marc Mesnil, Cronier, Laurent, Golthlay Denet, Monvoisin, Arnaud, Arnaud Monvoisin, Laurent Cronier, Balandre, Claire, Annie-Claire Balandre, Denet, Golthlay, Jonathan Clarhaut, Simonneau, Claire, Boucher, Jonathan, Jonathan Boucher   +15 more
core   +1 more source

Connexin Regulation and Modulation of Neural Stem Cell Differentiation Induced by Cell‐Permeable Itaconate

Journal of Cellular Physiology, Volume 241, Issue 5, May 2026.
The immunometabolite itaconate modulates the connexin profile of neural stem cells, and it upregulates Cx36‐based channels, promoting the differentiation toward a neuronal phenotype. These effects were abolished by connexin blockade, supporting a role for itaconate in the neuroimmune axis in inflammatory and neurodegenerative disorders. ABSTRACT Neural
Simona Denaro, Simona Rosa Spina, Simona D'Aprile, Anna Gervasi, Filippo Torrisi, Carmela Parenti, Agata Zappalà, Nunzio Vicario, Rosalba Parenti   +8 more
wiley   +1 more source

The Role of Pannexin-1 Channel- Review

, 2022
Three relations compose the Pannexin family of channel forming glycoproteins such as Pannexin-1 (Panx1, Gen-Bank AAQ89382.1, 426 amino-acids), Pannexin-2 (Panx2, Gen-Bank AAI01024.1, 74.4 kDa) and Pannexin-3 (Panx3, Gen-Bank AAK95655.1, 392 aminoacids, 44.7 kDa). Their primary performance is outlined by their capability to make single membrane channels
openaire   +2 more sources

Differential role of the pannexin-1/ATP/P2X7 axis in IL-1β release by human monocytes [PDF]

, 2017
IL - 1 β release is integral to the innate immune system. The release of mature IL - 1 β depends on two regulated events; (i) the de novo induction of pro - IL - 1 β , generally via NF κ B - depend ent transduction pathways and (ii) the assembly ...
Mark J. Paul‐Clark, Paul-Clark, Mark J., Mitchell, JA, Kirkby, NS, William R. Wright, Parzych, K, Wright, WR, Parzych, Katarzyna, Paul-Clark, M, Katarzyna Parzych, Zetterqvist, A, Jane A. Mitchell, Wright, William R., Kirkby, Nicholas S, Zetterqvist, Anna V., Mitchell, Jane A, Anna V. Zetterqvist, Nicholas S. Kirkby   +17 more
core   +1 more source

Efferocytosis: Signaling Pathways and New Therapeutic Strategies for Diseases

MedComm, Volume 7, Issue 5, May 2026.
1. Efferocytosis coordinates molecular signaling and metabolic reprogramming to resolve inflammation. 2. Efferocytosis dysfunction underlies four conserved pathological hallmarks across diseases. 3. Therapeutic strategies targeting efferocytosis should be context‐dependent: enhance or inhibit based on disease type. ABSTRACT Efferocytosis—the phagocytic
Lei Wang, Jingjing Ge, Zehua Wang, Yihua Fang, Yongxu Jia, Ruyue Zhang, Yanru Qin   +6 more
wiley   +1 more source