Results 71 to 80 of about 29,697,217 (152)

Measuring the amount of the channel protein pannexin 1 across neuronal development [PDF]

, 2022
My Presentation is on Pannexin 1 an ATP channel protein in the brain. I have analyzed both the theoretical side as well as the practical side of this protein.
Irwin, Eamonn
core  

Multifaceted Role of Extracellular Vesicles: Intercellular Messengers to Therapeutic Applications: A Narrative Review

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Extracellular vesicles (EVs) are nanoscale carriers, including exosomes, microvesicles, and apoptotic bodies, that mediate intercellular communication by transporting proteins, nucleic acids, lipids, and metabolites. They regulate immunity, tissue repair, and cell differentiation.
Kajal Kamra, Satya Kumar Lalam, Shefali Srivastava, Madan Kumar Arumugam, Lokesh Kumar Boopathy, Simran Takkar, Zhiqiu Xia, Sabarinath Peruvemba Subramanian   +7 more
wiley   +1 more source

Exercise training lowers arterial blood pressure independently of Pannexin 1 in men with essential hypertension

, 2022
Introduction: Regular exercise training reduces arterial blood pressure but the underlying mechanisms are unclear. Here, we evaluated the potential involvement of Pannexin 1, an ATP releasing channel, in the blood pressure-reducing effect of training ...
Gliemann, Lasse, THOMAS SVARE EHLERS, Kurell, Melanie Emmonds, LASSE GLIEMANN, SARAH Á RÒGVI TOLBORG, Møller, Sophie, SIMON SCHULTZ PATRZALEK, Hansen, Camilla Collin, CAMILLA COLLIN HANSEN, JORGE PÉREZ-GÓMEZ, YLVA HELLSTEN, Pérez-Gómez, Jorge, CHRISTINE MAULITZ, MELANIE EMMONDS KURELL, ANDREA TAMARIZ-ELLEMANN, Ehlers, Thomas Svare, Tamariz-Ellemann, Andrea, Maulitz, Christine, Hellsten, Ylva, Tolborg, Sarah Á Rògvi, Patrzalek, Simon Schultz, SOPHIE MØLLER   +21 more
core   +1 more source

Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1β release through a dye uptake-independent pathway [PDF]

, 2007
Pannexin-1 is a recently identified membrane protein that can act as a nonselective pore permeable to dyes such as ethidium when ectopically expressed.
Pelegrin, Pablo, Surprenant, Annmarie
core   +2 more sources

Periodontitis as a Model for Inflammatory Uncoupling of Bone Remodeling

Journal of Periodontal Research, Volume 61, Issue 6, Page 662-694, June 2026.
Periodontitis can be viewed as a state of inflammatory uncoupling of bone remodeling, in which excessive osteoclast‐mediated resorption coexists with impaired bone formation. This review integrates emerging insights from osteoimmunology, osteocyte biology, mechanobiology, aging, and resolution pathways to position periodontitis as an accessible in vivo
Rafael Scaf de Molon, Sotirios Tetradis, Rolando Vernal, Fabio Renato Manzolli Leite, Thomas E. Van Dyke   +4 more
wiley   +1 more source

Exacerbated ATP transmission in the carotid body is linked to glomus cell expansion in spontaneously hypertensive rats

The Journal of Physiology, Volume 604, Issue 12, Page 4678-4706, 15 June 2026.
Abstract figure legend Exacerbated ATP signalling in the carotid body (CB) of spontaneously hypertensive rats (SHRs) arises from expansion of the chemosensory glomus cell compartment and reduced extracellular ATP metabolism, leading to increased purinergic drive.
Igor S. A. Felippe, Audrys Pauza, Olivia M. S. Gold, Xin Shen, Fernanda Brognara, Rosanna Roberts Nonu, Dylan K. Pen, Aabharika Bose, Emma N. Bardsley, Anna P. Ponnampalam, Davi J. A. Moraes, Julian F. R. Paton   +11 more
wiley   +1 more source

Is the Pannexin-1 channel a mechanism underlying hypertension in humans? A translational study of human hypertension

, 2022
Background: In preclinical models, the pannexin-1 channel has been shown to be involved in blood pressure regulation through an effect on peripheral vascular resistance. Pannexin-1 releases ATP, which can activate constrictive purinergic receptors on the
Gliemann, Lasse, Ehlers, Thomas Svare, Tamariz-Ellemann, Andrea, Hellsten, Ylva, Møller, Sophie, Hansen, Camilla Collin   +5 more
core   +1 more source

Blockade of Pannexin-1 Channels and Purinergic P2X7 Receptors Shows Protective Effects Against Cytokines-Induced Colitis of Human Colonic Mucosa

Frontiers in Pharmacology, 2018
Introduction: The pannexin-1 (Panx1) channels are found in many cell types, and ATP released from these channels can act on nearby cells activating purinergic P2X7 receptors (P2X7R) which lead to inflammation.
Erica F. Diezmos, Irit Markus, D. S. Perera, Steven Gan, Li Zhang, Shaun L. Sandow, Shaun L. Sandow, Paul P. Bertrand, Paul P. Bertrand, Lu Liu   +9 more
doaj   +1 more source

A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP

, 2009
Pannexin 1 forms a large membrane channel that, based on its biophysical properties and its expression pattern, is a prime candidate to represent an ATP release channel. Pannexin 1 channel activity is potentially deleterious for cells as indicated by its
Dahl, Gerhard, Qiu, Feng
core   +1 more source

Baicalin inhibited PANX-1/P2Y6 signaling pathway activation in porcine aortic vascular endothelial cells infected by Glaesserella parasuis

Heliyon
Glaesserella parasuis can induce endothelial barrier damage in piglets, although the mechanism by which this pathogen triggers inflammatory damage remains unclear. Baicalin possesses anti-inflammatory and anti-oxidant activities.
Shulin Fu, Xinyue Tian, Chun Peng, Dan Zhang, Linglu Zhou, Yuzhen Yuan, Jing He, Ling Guo, Yinsheng Qiu, Chun Ye, Yu Liu, Bingbing Zong   +11 more
doaj   +1 more source