Results 101 to 110 of about 7,051 (198)

Relevance of Gap Junctions and Large Pore Channels in Traumatic Brain Injury

Frontiers in Physiology, 2014
In case of traumatic brain injury (TBI), occurrence of central nervous tissue damage is frequently aligned with local modulations of neuronal and glial gap junction channel expression levels.
Nora eProchnow
doaj   +1 more source

Source_file.xlsxCryo-EM structures of Pannexin 1 and 3 reveal differences among Pannexin isoforms

Pannexins are single-membrane large-pore ion channels that releases ions and ATP upon activation. Three isoforms of pannexins 1, 2, and 3, perform diverse cellular roles and differ in their pore lining residues.
Aravind Penmatsa (18020539), ASHISH APOTIKAR (18060037), NAZIA HUSSAIN (18060036)   +2 more
core   +1 more source

The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes

, 2009
The inflammasome is a multiprotein complex involved in innate immunity. Activation of the inflammasome causes the processing and release of the cytokines interleukins 1β and 18. In primary macrophages, potassium ion flux and the membrane channel pannexin
Locovei, Silviu, Dahl, Gerhard, Silverman, William R, de Rivero Vaccari, Juan Pablo, Scemes, Eliana, Qiu, Feng, Carlsson, Steven K, Keane, Robert W   +7 more
core   +1 more source

The role of pannexin/purinergic signaling in intervascular communication from capillaries during skeletal muscle contraction in male Golden hamsters

Physiological Reports
We sought to determine the physiological relevance of pannexin/purinergic‐dependent signaling in mediating conducted vasodilation elicited by capillary stimulation through skeletal muscle contraction.
Iain R. Lamb, Nicole M. Novielli‐Kuntz, Coral L. Murrant   +2 more
doaj   +1 more source

Investigation of olfactory function in a Panx1 knock out mouse model

Frontiers in Cellular Neuroscience, 2014
Pannexin 1 (Panx1), the most extensively investigated member of a channel-forming protein family, is able to form pores conducting molecules up to 1.5 kDa, like ATP, upon activation.
Stefan eKurtenbach, Paige eWhyte-Fagundes, Lian eGelis, Sarah eKurtenbach, Christiane eZoidl, Hanns eHatt, Valery I. Shestopalov, Georg eZoidl   +7 more
doaj   +1 more source

Molecular pathways of pannexin1-mediated neurotoxicity

Frontiers in Physiology, 2014
Pannexin1 (Panx1) forms nonselective membrane channels, structurally similar to gap junction hemichannels, that is permeable to ions, nucleotides and other small molecules below 900 Da. Panx1 activity is implicated in paracrine signaling and inflammasome
Valery I. Shestopalov, Valery I. Shestopalov, Valery I. Shestopalov, Vladlen Z. Slepak, Vladlen Z. Slepak   +4 more
doaj   +1 more source

A taste for ATP: neurotransmission in taste buds

Frontiers in Cellular Neuroscience, 2013
Not only is ATP a ubiquitous source of energy but it is also used widely as an intercellular signal. For example, keratinocytes release ATP in response to numerous external stimuli including pressure, heat and chemical insult. The released ATP activates
Thomas E. Finger, Sue C Kinnamon
doaj   +1 more source

Physiological roles of gap junction protein pannexin

, 2007
Open, unopposed gap junction hemichannels can be deleterious to a cell due to their large conductance and permeation properties. But brief openings of the hemichannels, triggered by a variety of stimuli, may be of physiological importance for cells.
Locovei, Silviu
core   +3 more sources

A “Swell” Way to Regulate Pannexin-Mediated ATP Release

, 2011
TRPV4 and RhoA signaling act upstream of pannexin 1 to mediate ATP release induced by osmotic cell swelling.
Heather M. Thompson
core   +1 more source

A throwback on 25 years in pannexin research

Current Opinion in Immunology
Cellular channels consisting of pannexins facilitate signaling between the intracellular and extracellular environment. In this respect, pannexin channel opening serves as a pivotal trigger for both inflammatory processes and cell death. While pannexin channels also contribute to normal physiological functions, their roles in pathological mechanisms ...
Daan Peeters, Mathieu Vinken, Raf Van Campenhout   +2 more
openaire   +3 more sources