Results 21 to 30 of about 6,586 (171)
The Cryo-EM structure of pannexin 1 reveals unique motifs for ion selection and inhibition
eLife, 2020 Pannexins are large-pore forming channels responsible for ATP release under a variety of physiological and pathological conditions. Although predicted to share similar membrane topology with other large-pore forming proteins such as connexins, innexins ...
Kevin Michalski +5 more
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Frontiers in Neurology, 2022 AimPrevious studies have proved that inhibiting inflammasome activation provides neuroprotection against early brain injury (EBI) after subarachnoid hemorrhage (SAH), which is mainly focused on the microglial inflammatory response, but the potential role
Yonghe Zheng +6 more
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Role of astroglial hemichannels and pannexons in Memory and Neurodegenerative diseases
Frontiers in Integrative Neuroscience, 2016 Under physiological conditions, astroglial hemichannels and pannexin channels allow the release of gliotransmitters from astrocytes. These gliotransmitters are critical in modulating synaptic transmission, plasticity and memory.
Juan Andrés Orellana +3 more
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Connexin and pannexin (hemi)channels in the liver
Frontiers in Physiology, 2014 The liver was among the first organs in which connexin proteins have been identified. Hepatocytes harbour connexin32 and connexin26, while non-parenchymal liver cells typically express connexin43.
Michaël eMaes +11 more
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Physiological Reports, 2023 Development of autosomal dominant polycystic kidney disease (ADPKD) involves renal epithelial cell abnormalities. Cystic fluid contains a high level of ATP that, among other effects, leads to a reduced reabsorption of electrolytes in cyst‐lining cells ...
Sergey N. Arkhipov +5 more
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Ubiquitination and Proteasomal Regulation of Pannexin 1 and Pannexin 3
, 2020 Pannexin 1 (PANX1) and Pannexin 3 (PANX3) are single-membrane channel glycoproteins that allow for communication between the cell and its environment to regulate cellular differentiation, proliferation, and apoptosis.
Blinder, Anna
core +1 more source
Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents [PDF]
, 2017 The release of ATP from spinal microglia via pannexin-1 channels is required for withdrawal symptoms after termination of chronic opioid treatment in rodents, and pharmacological blockade of pannexin-1 channels reduces the severity of withdrawal without ...
Burma, Nicole E +33 more
core +1 more source
P2X4 assembles with P2X7 and pannexin-1 in gingival epithelial cells and modulates ATP-induced reactive oxygen species production and inflammasome activation. [PDF]
PLoS ONE, 2013 We have previously reported that Porphyromonas gingivalis infection of gingival epithelial cells (GEC) requires an exogenous danger signal such as ATP to activate an inflammasome and caspase-1, thereby inducing secretion of interleukin (IL)-1β ...
Shu-Chen Hung +7 more
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Connexins, Pannexins and Gap Junctions in Perinatal Brain Injury
Biomedicines, 2022 Perinatal brain injury secondary to hypoxia-ischemia and/or infection/inflammation remains a major cause of disability. Therapeutic hypothermia significantly improves outcomes, but in randomized controlled trials nearly half of infants still died or ...
Alice McDouall +5 more
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Synaptic Functions of Hemichannels and Pannexons: A Double-Edged Sword
Frontiers in Molecular Neuroscience, 2018 The classical view of synapses as the functional contact between presynaptic and postsynaptic neurons has been challenged in recent years by the emerging regulatory role of glial cells.
Verónica Abudara +8 more
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