Results 21 to 30 of about 7,051 (198)
HIF‐Regulated Pannexin‐1 Channel Drives Luminal ATP Accumulation in Kidney Cysts [PDF]
The FASEB Journal, Volume 40, Issue 10, 31 May 2026.Autosomal dominant polycystic kidney disease causes progressive cyst enlargement in the kidneys, leading to hypoxia and induction of HIF‐1α. Our study identifies HIF‐1α‐dependent transcriptional upregulation of Pannexin1 (PANX1) in the apical membrane of cyst epithelial cells, promoting ATP release into the cyst lumen.
Kathrin Skoczynski +10 more
wiley +2 more sources
Connexin and pannexin (hemi)channels in the liver [PDF]
Frontiers in Physiology, 2014 The liver was among the first organs in which connexin proteins have been identified. Hepatocytes harbour connexin32 and connexin26, while non-parenchymal liver cells typically express connexin43.
Michaël eMaes +11 more
doaj +6 more sources
Dual Regulatory Roles of Pannexin 1 in the Pathogenesis and Recovery of Sepsis-Induced Acute Lung Injury. [PDF]
Infect Drug ResistQiancheng Xu,1,* Yan Qian,2,* Yingya Cao,1 Weihua Lu,1 Jianguo Li3 1Department of Critical Care Medicine, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, Anhui, 241000, People’s
Xu Q, Qian Y, Cao Y, Lu W, Li J.
europepmc +2 more sources
Pannexin-1 and other anion channels in platelets and megakaryocytes
, 2015 Platelet ion channels are essential for Ca2+-influx, maintaining the resting membrane potential and cell volume regulation. Cation channels have been widely studied but few reports of platelet anion channels exist.
Kirk Allen Taylor (7667516)
core +6 more sources
Pharmacology of pannexin channels
Current Opinion in Pharmacology, 2023 Pannexin channels play fundamental roles in regulating inflammation and have been implicated in many diseases including hypertension, stroke, and neuropathic pain. Thus, the ability to pharmacologically block these channels is a vital component of several therapeutic approaches.
Michael Koval +2 more
openaire +2 more sources
Activation and Inhibition of Pannexin 1 Channels [PDF]
, 2015 Pannexin 1 is one of three pannexins, a vertebrate protein family related to the invertebrate innexins. Unlike its innexin relatives, Pannexin 1 does not form gap junctions in vivo, but it does form plasma membrane channels that act as ATP release ...
Jackson, David
core +4 more sources
Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation [PDF]
Journal of Cell Science, 2010 Pannexin (Panx) 1 and Panx3 are integral membrane proteins that share some sequence homology with the innexin family of invertebrate gap junctions. They are expressed in mammalian skin. Pannexins have been reported to form functional mechanosensitive single-membrane channels, but their importance in regulating cellular function is poorly understood. In
Steven J, Celetti +5 more
openaire +2 more sources
Lymphatic Connexins and Pannexins in Health and Disease [PDF]
International Journal of Molecular Sciences, 2021 This review highlights current knowledge on the expression and function of connexins and pannexins, transmembrane channel proteins that play an important role in intercellular communication, in both the developing and mature lymphatic vasculature. A particular focus is given to the involvement of these proteins in functions of the healthy lymphatic ...
Avigail Ehrlich +3 more
openaire +2 more sources
Gap junctions, pannexins and pain [PDF]
Neuroscience Letters, 2019 Enhanced expression and function of gap junctions and pannexin (Panx) channels have been associated with both peripheral and central mechanisms of pain sensitization. At the level of the sensory ganglia, evidence includes augmented gap junction and pannexin1 expression in glial cells and neurons in inflammatory and neuropathic pain models and increased
David C, Spray, Menachem, Hanani
openaire +2 more sources
Pannexin-1 channel regulates nuclear content packaging into apoptotic bodies and their size
, 2021 Apoptotic bodies (ApoBDs), which are large extracellular vesicles exclusively released by apoptotic cells, possess therapeutically exploitable properties including biomolecule loadability and transferability.
Ivan Poon (9481238) +7 more
core +1 more source