Results 11 to 20 of about 5,491 (175)

Identification of Pannexins in Rat Nasal Mucosa

Allergy & Rhinology, 2013
Pannexins are a second family of gap-junction proteins in vertebrates, classified as pannexin-1, pannexin-2, and pannexin-3. Pannexin-1 is one of the candidates for channel-mediated ATP release into the extracellular space.
Toyoaki Ohbuchi M.D., Nobusuke Hohchi M.D., Jun-ichi Ohkubo M.D., Koichi Hashida M.D., Hiroki Koizumi M.D., Tetsuro Wakasugi M.D., Fumiko Takenaga M.D., Hideaki Suzuki M.D., Ph.D.   +7 more
doaj   +3 more sources

The Pannexins: Past and Present [PDF]

Frontiers in Physiology, 2014
The pannexins (Panxs) are a family of chordate proteins homologous to the invertebrate gap junction forming proteins named innexins. Three distinct Panx paralogs (Panx1, Panx2, and Panx3) are shared among the major vertebrate phyla, but they appear to ...
Steven eBond, Steven eBond, Christian C. Naus   +2 more
doaj   +3 more sources

Connexin and pannexin (hemi)channels in the liver [PDF]

Frontiers in Physiology, 2014
The liver was among the first organs in which connexin proteins have been identified. Hepatocytes harbour connexin32 and connexin26, while non-parenchymal liver cells typically express connexin43.
Michaël eMaes, Elke eDecrock, Bruno eCogliati, André G Oliveira, Pedro E Marques, Maria Lucia eZaidan Dagli, Gustavo B Menezes, Gregory eMennecier, Luc eLeybaert, Tamara eVanhaecke, Vera eRogiers, Mathieu eVinken   +11 more
doaj   +6 more sources

Pannexin channels in inflammation and tumorigenesis

Frontiers in Cell and Developmental Biology
Pannexin (Panx) channels are oligomeric heptamers of PANX proteins, comprising Panx1, Panx2 and Panx3. These channels facilitate the extracellular release of signaling molecules up to 1.5 kDa in size, including adenosine triphosphate (ATP), amino acids ...
Mengmeng Jiang, Mengmeng Jiang, Xiaojia Li, Xiaojia Li, Keping Xie, Keping Xie   +5 more
doaj   +4 more sources

HIF-Regulated Pannexin-1 Channel Drives Luminal ATP Accumulation in Kidney Cysts. [PDF]

FASEB J
Autosomal dominant polycystic kidney disease causes progressive cyst enlargement in the kidneys, leading to hypoxia and induction of HIF‐1α. Our study identifies HIF‐1α‐dependent transcriptional upregulation of Pannexin1 (PANX1) in the apical membrane of cyst epithelial cells, promoting ATP release into the cyst lumen.
Skoczynski K, Scholz JK, Ursu R, Schödel J, Grampp S, Naas S, Lauer V, Schiffer M, Büttner-Herold M, Buchholz B, Kraus A.   +10 more
europepmc   +2 more sources

Pannexin channels in the kidney. [PDF]

Am J Physiol Renal Physiol
Renal dysfunction leads to critical health conditions, including acute kidney injury (AKI) and chronic kidney disease (CKD), and is a driver of hypertension. Despite their global prevalence and impact, the pathophysiology for all kidney disease subtypes is incompletely understood; therefore, many patients progress to kidney failure, needing dialysis ...
Williams MD, O'Donnell BL, Columbus L, DeLalio LJ, Erdbrügger U, Isakson BE.   +5 more
europepmc   +3 more sources

Pannexins in the vasculature. [PDF]

Am J Physiol Heart Circ Physiol
Pannexins (PANX1, PANX2, PANX3) are a family of large-pore, ion and metabolite channels present throughout the blood and lymphatic vascular networks. PANX1 has near-ubiquitous expression in the cardiovascular system and is the most highly studied pannexin in both homeostatic and disease conditions.
O'Donnell BL, Williams MD, Billaud M, Dunaway LS, Columbus L, Koval M, Isakson BE.   +6 more
europepmc   +4 more sources

Pharmacology of pannexin channels

Current Opinion in Pharmacology, 2023
Pannexin channels play fundamental roles in regulating inflammation and have been implicated in many diseases including hypertension, stroke, and neuropathic pain. Thus, the ability to pharmacologically block these channels is a vital component of several therapeutic approaches.
Michael Koval, Wyatt J. Schug, Brant E. Isakson   +2 more
openaire   +2 more sources

Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation [PDF]

Journal of Cell Science, 2010
Pannexin (Panx) 1 and Panx3 are integral membrane proteins that share some sequence homology with the innexin family of invertebrate gap junctions. They are expressed in mammalian skin. Pannexins have been reported to form functional mechanosensitive single-membrane channels, but their importance in regulating cellular function is poorly understood. In
Steven J, Celetti, Kyle N, Cowan, Silvia, Penuela, Qing, Shao, Jared, Churko, Dale W, Laird   +5 more
openaire   +2 more sources

Small Cell Lung Cancer Establishes a Metabolic Autocrine Mechanism Through Active Extracellular ATP Transport. [PDF]

Cancer Sci
Small cell lung cancer (SCLC) actively exports ATP through PANX1 channels, triggering P2RX7‐mediated autocrine signaling and promoting tumor proliferation. Inhibition of PANX1 or P2RX7 disrupts this loop and suppresses tumor growth. ABSTRACT Small cell lung cancer (SCLC) is an aggressive malignancy with a 5‐year survival rate of less than 7%.
Tsuruda T, Kodama M, Nakayama KI.
europepmc   +2 more sources