Cryo-EM structures of pannexin 1 and 3 reveal differences among pannexin isoforms [PDF]
Nature CommunicationsPannexins are single-membrane large-pore channels that release ions and ATP upon activation. Three isoforms of pannexins 1, 2, and 3, perform diverse cellular roles and differ in their pore lining residues.
Nazia Hussain +7 more
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Perspectives on the role of Pannexin 1 in neural precursor cell biology
Neural Regeneration Research, 2016 We recently reported that targeted deletion of Pannexin 1 in neural precursor cells of the ventricular zone impairs the maintenance of these cells in healthy and stroke-injured brain. Here we frame this exciting new finding in the context of our previous
Juan C Sanchez-Arias +2 more
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Mechanisms of SARS-CoV-2 and Male Infertility: Could Connexin and Pannexin Play a Role?
Frontiers in Physiology, 2022 The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on male infertility has lately received significant attention. SARS-CoV-2, the virus that causes coronavirus disease (COVID-19) in humans, has been shown to impose adverse effects
Temidayo S. Omolaoye +4 more
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Pannexin-1 channel regulates nuclear content packaging into apoptotic bodies and their size
, 2021 Apoptotic bodies (ApoBDs), which are large extracellular vesicles exclusively released by apoptotic cells, possess therapeutically exploitable properties including biomolecule loadability and transferability.
Ivan Poon (9481238) +7 more
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Biology, 2021 Intracerebral hemorrhage (ICH) is a devastating disease with high mortality and morbidity; the mortality rate ranges from 40% at 1 month to 54% at 1 year; only 12–39% achieve good outcomes and functional independence.
Yan Zhang +6 more
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Dual Regulatory Roles of Pannexin 1 in the Pathogenesis and Recovery of Sepsis-Induced Acute Lung Injury. [PDF]
Infect Drug ResistQiancheng Xu,1,* Yan Qian,2,* Yingya Cao,1 Weihua Lu,1 Jianguo Li3 1Department of Critical Care Medicine, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, Anhui, 241000, People’s
Xu Q, Qian Y, Cao Y, Lu W, Li J.
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Contribution of large-pore channels to inflammation induced by microorganisms
Frontiers in Cell and Developmental Biology, 2023 Plasma membrane ionic channels selectively permeate potassium, sodium, calcium, and chloride ions. However, large-pore channels are permeable to ions and small molecules such as ATP and glutamate, among others.
José L. Vega +6 more
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Functional implications of calcium permeability of the channel formed by pannexin 1. [PDF]
, 2006 Although human pannexins (PanX) are homologous to gap junction molecules, their physiological function in vertebrates remains poorly understood. Our results demonstrate that overexpression of PanX1 results in the formation of Ca(2+)-permeable gap ...
Ivanov, Dmitry, V +31 more
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Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism. [PDF]
PLoS ONE, 2014 P2X7 is a ligand-gated ion channel which is activated by ATP and displays secondary permeability characteristics. The mechanism of development of the secondary permeability pathway is currently unclear, although a role for the hemichannel protein ...
Archana Bhaskaracharya +7 more
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Identification of Pannexins in Rat Nasal Mucosa
Allergy & Rhinology, 2013 Pannexins are a second family of gap-junction proteins in vertebrates, classified as pannexin-1, pannexin-2, and pannexin-3. Pannexin-1 is one of the candidates for channel-mediated ATP release into the extracellular space.
Toyoaki Ohbuchi M.D. +7 more
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