Results 11 to 20 of about 7,051 (198)

Pannexin channels in the kidney. [PDF]

Am J Physiol Renal Physiol
Renal dysfunction leads to critical health conditions, including acute kidney injury (AKI) and chronic kidney disease (CKD), and is a driver of hypertension. Despite their global prevalence and impact, the pathophysiology for all kidney disease subtypes is incompletely understood; therefore, many patients progress to kidney failure, needing dialysis ...
Williams MD, O'Donnell BL, Columbus L, DeLalio LJ, Erdbrügger U, Isakson BE.   +5 more
europepmc   +3 more sources

Pannexin 1 Modulates Axonal Growth in Mouse Peripheral Nerves [PDF]

Frontiers in Cellular Neuroscience, 2017
The pannexin family of channels consists of three members—pannexin-1 (Panx1), pannexin-2 (Panx2), and pannexin-3 (Panx3) that enable the exchange of metabolites and signaling molecules between intracellular and extracellular compartments.
Steven M. Horton, Carlos Luna Lopez, Elisabeth Blevins, Elisabeth Blevins, Holly Howarth, Jake Weisberg, Valery I. Shestopalov, Helen P. Makarenkova, Sameer B. Shah, Sameer B. Shah, Sameer B. Shah   +10 more
doaj   +3 more sources

ATP Release and Purinergic Signaling Potentiate β‐Adrenergic Effects on Brown Adipocytes [PDF]

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim Brown adipose tissue (BAT) specializes in energy consumption and thermogenesis in response to cold stress. Brown adipocytes (BA) express purinergic receptors, yet little is known about the source of extracellular ATP and the role of purinergic signaling, and the potential interaction with β‐adrenergic signaling.
Marco Tozzi, Emilie B. Berggreen, Rui Zhang, Anders Gudiksen, Wei Li, Mathias B. Matz, Henriette Pilegaard, Jacob B. Hansen, Ivana Novak   +8 more
wiley   +2 more sources

Ultrastructural Characterization of Pannexin 1 Expression Along the Rat Nephron. [PDF]

Int J Mol Sci
Pannexins are transmembrane glycoproteins that share structural and functional similarities with the gap junction proteins innexins and connexins. They play a critical role in paracrine and intracellular signalling, including purinergic signalling via ...
Bočina I, Kević N, Restović I, Jerčić L, Jelinčić Korčulanin M, Vukojević K, Filipović N.   +6 more
europepmc   +2 more sources

Pannexins in the vasculature. [PDF]

Am J Physiol Heart Circ Physiol
Pannexins (PANX1, PANX2, PANX3) are a family of large-pore, ion and metabolite channels present throughout the blood and lymphatic vascular networks. PANX1 has near-ubiquitous expression in the cardiovascular system and is the most highly studied pannexin in both homeostatic and disease conditions.
O'Donnell BL, Williams MD, Billaud M, Dunaway LS, Columbus L, Koval M, Isakson BE.   +6 more
europepmc   +4 more sources

Cryo-EM structures of pannexin 1 and 3 reveal differences among pannexin isoforms [PDF]

Nature Communications
Pannexins are single-membrane large-pore channels that release ions and ATP upon activation. Three isoforms of pannexins 1, 2, and 3, perform diverse cellular roles and differ in their pore lining residues.
Nazia Hussain, Ashish Apotikar, Shabareesh Pidathala, Sourajit Mukherjee, Ananth Prasad Burada, Sujit Kumar Sikdar, Kutti R. Vinothkumar, Aravind Penmatsa   +7 more
doaj   +2 more sources

Ubiquitination and Proteasomal Regulation of Pannexin 1 and Pannexin 3

, 2020
Pannexin 1 (PANX1) and Pannexin 3 (PANX3) are single-membrane channel glycoproteins that allow for communication between the cell and its environment to regulate cellular differentiation, proliferation, and apoptosis.
Blinder, Anna
core   +3 more sources

Perspectives on the role of Pannexin 1 in neural precursor cell biology

Neural Regeneration Research, 2016
We recently reported that targeted deletion of Pannexin 1 in neural precursor cells of the ventricular zone impairs the maintenance of these cells in healthy and stroke-injured brain. Here we frame this exciting new finding in the context of our previous
Juan C Sanchez-Arias, Leigh E Wicki-Stordeur, Leigh Anne Swayne   +2 more
doaj   +2 more sources

Identification of Pannexins in Rat Nasal Mucosa

Allergy & Rhinology, 2013
Pannexins are a second family of gap-junction proteins in vertebrates, classified as pannexin-1, pannexin-2, and pannexin-3. Pannexin-1 is one of the candidates for channel-mediated ATP release into the extracellular space.
Toyoaki Ohbuchi M.D., Nobusuke Hohchi M.D., Jun-ichi Ohkubo M.D., Koichi Hashida M.D., Hiroki Koizumi M.D., Tetsuro Wakasugi M.D., Fumiko Takenaga M.D., Hideaki Suzuki M.D., Ph.D.   +7 more
doaj   +3 more sources

The Pannexins: Past and Present [PDF]

Frontiers in Physiology, 2014
The pannexins (Panxs) are a family of chordate proteins homologous to the invertebrate gap junction forming proteins named innexins. Three distinct Panx paralogs (Panx1, Panx2, and Panx3) are shared among the major vertebrate phyla, but they appear to ...
Steven eBond, Steven eBond, Christian C. Naus   +2 more
doaj   +3 more sources