Results 31 to 40 of about 40,743 (260)

Degradation and modification of cochlear gap junction proteins in the early development of age-related hearing loss

Experimental and Molecular Medicine, 2020
Hearing loss: Disruption at the junction A decrease in the levels of connexin proteins at the junctions connecting cells in the inner-ear precedes age-related hearing loss (ARHL) in mice.
Shori Tajima, Keiko Danzaki, Katsuhisa Ikeda, Kazusaku Kamiya   +3 more
doaj   +1 more source

Air-stimulated ATP release from keratinocytes occurs through connexin hemichannels. [PDF]

PLoS ONE, 2013
Cutaneous ATP release plays an important role in both epidermal stratification and chronic pain, but little is known about ATP release mechanisms in keratinocytes that comprise the epidermis.
Travis P Barr, Phillip J Albrecht, Quanzhi Hou, Alexander A Mongin, Gary R Strichartz, Frank L Rice   +5 more
doaj   +1 more source

Primary cultures of chick osteocytes retain functional gap junctions between osteocytes and between osteocytes and osteoblasts [PDF]

, 2008
The inaccessibility of osteocytes due to their embedment in the calcified bone matrix in vivo has precluded direct demonstration that osteocytes use gap junctions as a means of intercellular communication.
Sugawara, Yasuyo, Kamioka, Hiroshi, Murshid, Sakhr A., Ishihara, Yoshihito, Ris, Hans, Yamamoto, Teruko Takano, Lim, Soo-Siang   +6 more
core   +1 more source

Functional implications of calcium permeability of the channel formed by pannexin 1. [PDF]

, 2006
Although human pannexins (PanX) are homologous to gap junction molecules, their physiological function in vertebrates remains poorly understood. Our results demonstrate that overexpression of PanX1 results in the formation of Ca(2+)-permeable gap ...
Ivanov, Dmitry, V, Panchin, YV, Vanden Abeele, F, Fabien Vanden Abeele, Panchin, Yuri V, Gordienko, D, Yuri V. Panchin, Baranova, AV, Skryma, R, Baranova, Ancha, V, Skryma, Roman, Gordienko, Dmitri, Gabriel Bidaux, Beck, Benjamin, Ivanov, DV, Prevarskaya, N, Ancha V. Baranova, Baranova, Ancha V, Natalia Prevarskaya, Benjamin Beck, Ivanov, Dmitry V, Panchin, Yuri, Ivanov, Dimitri, Prevarskaya, Natalia, Vanden Abeele, Fabien, Bidaux, G, Bidaux, Gabriel, Dmitry V. Ivanov, Beck, B, Panchin, Yuri, V, Roman Skryma, Dmitri Gordienko   +31 more
core   +1 more source

Phylogeny of teleost connexins reveals highly inconsistent intra- and interspecies use of nomenclature and misassemblies in recent teleost chromosome assemblies

BMC Genomics, 2020
Background Based on an initial collecting of database sequences from the gap junction protein gene family (also called connexin genes) in a few teleosts, the naming of these sequences appeared variable. The reasons could be (i) that the structure in this
Svein-Ole Mikalsen, Marni Tausen, Sunnvør í Kongsstovu   +2 more
doaj   +1 more source

Gap junctions modulate interkinetic nuclear movement in retinal progenitor cells [PDF]

, 2005
During early retinal development, progenitor cells must divide repeatedly to expand the progenitor pool. During G1 and G2 of the cell cycle, progenitor cell nuclei migrate back-and-forth across the proliferative zone in a process termed interkinetic ...
Lüneborg, N.L., Mobbs, Peter, Becker, D.L., Becker, David L., Pearson, R.A., Mobbs, P., Pearson, Rachael A.; id_orcid, Lüneborg, Nanna L.   +7 more
core   +1 more source

Connexin Mutants and Cataracts [PDF]

Frontiers in Pharmacology, 2013
The lens is a multicellular, but avascular tissue that must stay transparent to allow normal transmission of light and focusing of it on the retina. Damage to lens cells and/or proteins can cause cataracts, opacities that disrupt these processes.
Beyer, Eric C., Ebihara, Lisa, Berthoud, Viviana M.   +2 more
openaire   +3 more sources

Systemic Inflammation Rapidly Induces Reversible Atrial Electrical Remodeling: The Role of Interleukin‐6–Mediated Changes in Connexin Expression

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Systemic inflammation is a strong predictor of atrial fibrillation. A key role for electrical remodeling is increasingly recognized, and experimental data suggest that inflammatory cytokines can directly affect connexins resulting in gap ...
Pietro Enea Lazzerini, Franco Laghi‐Pasini, Maurizio Acampa, Ujala Srivastava, Iacopo Bertolozzi, Beatrice Giabbani, Francesco Finizola, Francesca Vanni, Aleksander Dokollari, Mariarita Natale, Gabriele Cevenini, Enrico Selvi, Nicola Migliacci, Massimo Maccherini, Mohamed Boutjdir, Pier Leopoldo Capecchi   +15 more
doaj   +1 more source

Structural and functional diversity of connexin genes in the mouse and human genome [PDF]

, 2002
Gap junctions are clustered channels between contacting cells through which direct intercellular communication via diffusion of ions and metabolites can occur.
Willecke, K, Güldenagel, M, Söhl, G, Eiberger, J, Romualdi, A, Deutsch, U, Eckardt, D, Degen, J   +7 more
core   +2 more sources

Gap junction proteins and their role in spinal cord injury

Frontiers in Molecular Neuroscience, 2015
Gap junctions are specialized intercellular communication channels that are formed by two hexameric connexin hemichannels, one provided by each of the two adjacent cells.
Ryan S Tonkin, Yilin eMao, Simon J O`Carroll, Louise eNicholson, Colin eGreen, Catherine eGorrie, Gila eMoalem-Taylor   +6 more
doaj   +1 more source