Results 51 to 60 of about 56,231 (274)
Expression of connexins and pannexins in diseased human liver
EXCLI Journal : Experimental and Clinical Sciences, 2022 Connexin proteins can form hexameric hemichannels and gap junctions that mediate paracrine and direct intercellular communication, respectively. Gap junction activity is crucial for the maintenance of hepatic homeostasis, while connexin hemichannels ...
Kaat Leroy +8 more
doaj +1 more source
Connexin 43 plays a role in pulmonary vascular reactivity in mice [PDF]
, 2018 Pulmonary arterial hypertension (PAH) is a chronic condition characterized by vascular remodeling and increased vaso-reactivity. PAH is more common in females than in males (~3:1).
Andrew Shaw +11 more
core +1 more source
Advanced Functional Materials, EarlyView.A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo +7 more
wiley +1 more source
Electrical coupling between ventricular myocytes and myofibroblasts in the infarcted mouse heart [PDF]
, 2017 Aims: Recent studies have demonstrated electrotonic coupling between scar tissue and the surrounding myocardium in cryoinjured hearts. However, the electrical dynamics occurring at the myocyte-nonmyocyte interface in the fibrotic heart remain ...
Conway, Simon J. +6 more
core +1 more source
Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels
Advanced Healthcare Materials, EarlyView.We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa +8 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2015 Hearing loss due to mutations in the connexin gene family which encodes gap junctional proteins is a common form of hereditary deafness. In particular, connexin 26 (Cx26, GJB2) mutations are responsible for ~50% of nonsyndromic hearing loss, which is the
Jeffrey C Wingard, Hong-Bo eZhao
doaj +1 more source
RhoA GTPase switch controls Cx43-hemichannel activity through the contractile system [PDF]
, 2012 ATP-dependent paracrine signaling, mediated via the release of ATP through plasma membrane-embedded hemichannels of the connexin family, coordinates a synchronized response between neighboring cells.
Bultynck, Geert +7 more
core +3 more sources
Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling
Advanced Healthcare Materials, EarlyView.Emerging advances in three‐dimensional bioprinting and computational modeling are reshaping cardiovascular (CV) research by enabling more realistic, patient‐specific tissue platforms. This review surveys cutting‐edge approaches that merge biomimetic CV constructs with computational simulations to overcome the limitations of traditional models, improve ...
Tanmay Mukherjee +7 more
wiley +1 more source
Compartmentalized and signal-selective gap junctional coupling in the hearing cochlea [PDF]
, 2006 Gap junctional intercellular communication (GJIC) plays a major role in cochlear function. Recent evidence suggests that connexin 26 (Cx26) and Cx30 are the major constituent proteins of cochlear gap junction channels, possibly in a unique heteromeric ...
Forge, A, Jagger, DJ
core +1 more source
Frontiers in Neuroscience, 2020 Donepezil is a potent acetylcholinesterase inhibitor, largely used worldwide to alleviate cognitive symptoms in Alzheimer’s disease (AD). Beyond the widely described neuronal impact of donepezil, it was recently shown that targeting connexins, the ...
Benjamin Vidal +9 more
doaj +1 more source