Results 51 to 60 of about 40,743 (260)

Engineering Pluripotent Stem Cells‐Derived Inner Ear Organoids With Enhanced Maturation and Reproducibility by Micro‐Topographical Cues

Advanced Materials, EarlyView.
Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma, Jungeun Lim, Woochan Kim, Yeon Ju Kim, Dream Kim, Shinyull Lee, Chaeyeon Park, Stephen Rhee, Shruthy Kuttapan, Jungho Ha, Sang Wook Park, Kyunghoon Kim, Noo Li Jeon, Sunho Park, Yun‐Hoon Choung, Jangho Kim   +15 more
wiley   +1 more source

Pharmaco-fUS for Characterizing Drugs for Alzheimer’s Disease – The Case of THN201, a Drug Combination of Donepezil Plus Mefloquine

Frontiers in Neuroscience, 2020
Donepezil is a potent acetylcholinesterase inhibitor, largely used worldwide to alleviate cognitive symptoms in Alzheimer’s disease (AD). Beyond the widely described neuronal impact of donepezil, it was recently shown that targeting connexins, the ...
Benjamin Vidal, Benjamin Vidal, Marine Droguerre, Marco Valdebenito, Luc Zimmer, Luc Zimmer, Luc Zimmer, Michel Hamon, Franck Mouthon, Mathieu Charvériat   +9 more
doaj   +1 more source

Analysis of Hemichannels and Gap Junctions: Application and Extension of the Passive Transmembrane Ion Transport Model

Frontiers in Cellular Neuroscience, 2021
Electrical synaptic transmission is an essential form of interneuronal communication which is mediated by gap junctions that permit ion flow. Three gene families (connexins, innexins, and pannexins) have evolved to form gap junctional channels.
Qiqian Wang, Shenquan Liu
doaj   +1 more source

Molecular and functional characterization of gap junctions in the avian inner ear. [PDF]

, 2006
To analyze the fundamental role of gap junctions in the vertebrate inner ear, we examined molecular and functional characteristics of gap junctional communication (GJC) in the auditory and vestibular system of the chicken.
Nickel, R, Becker, D, Forge, A
core  

Cyclic Mechanical Loading of Cardiomyocytes via Pressure‐Driven Non‐Planar Membrane Deformation in a Bioreactor System

Advanced Science, EarlyView.
In this research article, Mansoor and coworkers present a novel device that applies controlled mechanical stimuli to cardiomyocytes using pressure‐driven membrane deformation. By exposing cells to physiologically and pathologically relevant loading conditions, the platform reproduces distinct structural, functional and molecular responses associated ...
Haris Mansoor, Gabrielle Juul, Jil Patel, Heran Pradhan, Gram Hepner, Jackson Jewell, Mark Bardin, Ryan Slusser, Abigail Glezer, Leda Klouda, Melikhan Tanyeri, Anita Saraf   +11 more
wiley   +1 more source

Cellular and deafness mechanisms underlying connexin mutation induced hearing loss – A common hereditary deafness

Frontiers in Cellular Neuroscience, 2015
Hearing loss due to mutations in the connexin gene family which encodes gap junctional proteins is a common form of hereditary deafness. In particular, connexin 26 (Cx26, GJB2) mutations are responsible for ~50% of nonsyndromic hearing loss, which is the
Jeffrey C Wingard, Hong-Bo eZhao
doaj   +1 more source

Divergence between Hemichannel and Gap Junction Permeabilities of Connexin 30 and 26

Life, 2023
Cx30 has been proposed to play physiological functions in the kidney and cochlea, and this has often been associated with its hemichannel role (deafness mutants frequently affecting hemichannels more than gap junctions), implicated in ATP release.
Ji Xu, Bruce J. Nicholson
doaj   +1 more source

Connexin-43 (Cx43) channels do not mediate the mean event probability.

, 2019
(A) Localization of Cx43 (white in the Cx43 only image, yellow in the composite image). Cells were counter-stained with rhodamine phalloidin (red) and DAPI (blue).
Sung Jun Son (6631073), Yoonjoo Lee (6631064), Min Tae Kim (4856773), Vickery Trinkaus-Randall (136486), Garrett Rhodes (6631067), Christopher V. Gabel (105542), Vijaya B. Kolachalama (256506), Kelsey Sack (6631070), Celeste B. Rich (136484)   +8 more
core   +1 more source

Regulation of connexin expression [PDF]

, 2005
Gap junctions contain cell–cell communicating channels that consist of multimeric proteins called connexins and mediate the exchange of low-molecular-weight metabolites and ions between contacting cells.
Oyamada, Masahito, Tetsuro Takamatsu, Takamatsu, Tetsuro, Yumiko Oyamada, Masahito Oyamada, Oyamada, Yumiko   +5 more
core   +1 more source

Celastrol‐Loaded Conductive Hydrogel Mitigates Myocardial Ischemia‐Reperfusion Injury and Restores Electrophysiological Function

Advanced Science, EarlyView.
Schematic illustration of the Pluronic F127 diacrylate/gelatin methacryloyl/poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate)/celastrol hydrogel (FGPC) for localized myocardial ischemia–reperfusion injury treatment. FGPC combines sustained celastrol delivery with PEDOT:PSS‐mediated conductive support to attenuate acute oxidative/inflammatory ...
Shixin Wang, Shaojie Chen, Chengzong Li, Hongyi Cheng, Jincheng Jiao, Xiafeng Peng, Yike Zhang, Wei Sun, Feng Zhang, Chang Cui, Minglong Chen   +10 more
wiley   +1 more source