Results 71 to 80 of about 40,743 (260)
The Anatomical Record, EarlyView.Abstract The vertebrate skull is composed of bones derived from neural crest cells and mesoderm. The evolutionary capacity of the skull has been linked, in part, to the emergence of neural crest cells; however, this increased capacity for evolutionary change requires that variation within neural crest‐ and mesoderm‐derived bones remains partly ...
Alyssa C. Moore +5 more
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Connexin 46 and Connexin 50 in Selenite Cataract
Ophthalmic Research, 2005 The purpose of this work was to determine if the lens gap junction proteins connexin 46 (Cx46) and connexin 50 (Cx50) were altered with the development of selenite-induced cataract. Cataracts were induced in young Sprague-Dawley rats with a single subcutaneous injection of sodium selenite; age-matched uninjected rats served as controls.
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Connexin hemichannels in the lens [PDF]
Frontiers in Physiology, 2014 The normal function and survival of cells in the avascular lens is facilitated by intercellular communication through an extensive network of gap junctions formed predominantly by three connexins (Cx43, Cx46, and Cx50). In expression systems, these connexins can all induce hemichannel currents, but other lens proteins (e.g., pannexin1) can also induce ...
Beyer, Eric C., Berthoud, Viviana M.
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Clinical Anatomy, EarlyView.ABSTRACT Human atrial chambers derive from distinct embryonic anlagens, the original embryonic atria gradually transforming into the so‐called auricles, or atrial appendages. This study quantifies macroscopic variations in pectinate muscle architecture in human atrial appendages and evaluates their visualization using clinical imaging modalities.
Markéta Lexová +11 more
wiley +1 more source
Connexins and their channels in inflammation [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2016 Inflammation may be caused by a variety of factors and is a hallmark of a plethora of acute and chronic diseases. The purpose of inflammation is to eliminate the initial cell injury trigger, to clear out dead cells from damaged tissue and to initiate tissue regeneration.
Joost Willebrords +9 more
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Cancer Connectors: Connexins, Gap Junctions, and Communication
Frontiers in Oncology, 2018 Despite concerted clinical and research efforts, cancer is a leading cause of death worldwide. Surgery, radiation, and chemotherapy have remained the most common standard-of-care strategies against cancer for decades.
Maksim Sinyuk +11 more
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Developmental Dynamics, EarlyView.Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
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Connexins are polytopic domain membrane proteins that form hexameric hemichannels (HCs) which can assemble into gap junction channels (GJCs) at the interface of two neighboring cells. The HCs may be involved in ion and small-molecule transport across the
Lavriha, Pia (author) +2 more
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Role of SoxE transcription factors in development and disease
Developmental Dynamics, EarlyView.Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
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Connexins and apoptotic transformation [PDF]
Biochemical Pharmacology, 2003 We examined the influence of connexin (Cx) expression on the development of apoptosis in HeLa parental cells (coupling deficient cell line) and HeLa cells expressing wild-type Cx43 and Cxs fused with enhanced green fluorescent protein (EGFP). EGFP was attached to the C-terminus of Cx32 and Cx43, Cx32-EGFP and Cx43-EGFP, respectively, and to the N ...
Audrone, Kalvelyte +4 more
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