Results 81 to 90 of about 40,743 (260)
Scientific Reports, 2017 We have previously shown that in vitro transduction with bovine adeno–associated viral (BAAV) vectors restores connexin expression and rescues gap junction coupling in cochlear organotypic cultures from connexin–deficient mice that are models DFNB1 ...
Giulia Crispino +7 more
doaj +1 more source
Triggered Calcium Lightning Programs Cochlear Development
Exploration, EarlyView.Summary: Before the onset of hearing, the developing inner ear generates spontaneous calcium signals that are thought to guide maturation. In this study, we discovered a rapid and widespread calcium flash—dubbed “Ca2+ lightning”—originating from supporting cells beneath the sensory hair cells, which triggers coordinated calcium waves across the entire ...
Qiang Ma +13 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2019 Clinical evidence has revealed that children born from mothers exposed to viral and bacterial pathogens during pregnancy are more likely to suffer various neurological disorders including schizophrenia, autism bipolar disorder, major depression, epilepsy,
Carolina E. Chávez +6 more
doaj +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Particulate matter (PM) is a major global health threat, linked to millions of deaths annually. Beyond inhalation, PM components reach the gastrointestinal tract through the mucociliary escalator or contaminated food and water. Among PM's organic fraction, redox‐active quinones such as 1,2‐naphthoquinone (NQ) and 9,10‐phenanthrenequinone (PQ ...
Franco Cervellati +6 more
wiley +1 more source
Dataset to: Expression and Function of Connexin 43 and Connexin 37 in the Murine Zona Glomerulosa
, 2022 This is the dataset used in the publication "Expression and Function of Connexin 43 and Connexin 37 in the Murine Zona ...
Hellmig, Nicole +5 more
core +1 more source
Med Research, EarlyView.This review summarizes the immuno‐inflammatory mechanisms driving the pathogenesis of osteoarthritis (OA), extending beyond the traditional view of OA as a purely degenerative disease to incorporate immune cell infiltration, inflammatory factor release, and the formation of a chronic low‐grade inflammatory microenvironment.
Qingqiang Lei +9 more
wiley +1 more source
Anais da Academia Brasileira de Ciências, 2004 We examined gap junction communication in an in vitro model of hematopoiesis, using the murine bone marrow stroma cell line S-17, and primary cultures of murine marrow-derived blood cell precursors.
Bodi Estevão +4 more
doaj
ATP Releasing Connexin 30 Hemichannels Mediate Flow-Induced Calcium Signaling in the Collecting Duct
Frontiers in Physiology, 2013 ATP in the renal tubular fluid is an important regulator of salt and water reabsorption via purinergic calcium signaling that involves the P2Y2 receptor, ENaC and AQP2.
Per eSvenningsen +3 more
doaj +1 more source
Allergy, EarlyView.Mitochondrial fatty acid enzyme, CPT1A, is deficient in the airway epithelium of severe asthma patients. Restoration of CPT1A expression improved epithelial barrier integrity via increasing mitochondrial respiration and ATP production in airway epithelial cells. Restoration of deficient epithelial CPT1A may represent a new treatment approach for severe
Muyun Wang +12 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2019 Connexins (Cxs) are ubiquitous membrane proteins that are found throughout vertebrate organs, acting as building blocks of the gap junctions (GJs) known to play vital roles in the normal function of many organs.
Xuewen Wu +4 more
doaj +1 more source