Results 51 to 60 of about 9,855 (254)

Connexin 43 in Mitochondria: What Do We Really Know About Its Function?

Frontiers in Physiology, 2022
Connexins are known for their ability to mediate cell-cell communication via gap junctions and also form hemichannels that pass ions and molecules over the plasma membrane when open.
Kerstin Boengler, Luc Leybaert, Marisol Ruiz-Meana, Rainer Schulz   +3 more
doaj   +1 more source

Gap Junction-Dependent and -Independent Functions of Connexin43 in Biology

Biology, 2022
For the first time in animal evolution, the emergence of gap junctions allowed direct exchanges of cellular substances for communication between two cells.
Yi Zhu
doaj   +1 more source

Structure and permeability of ion-channels by integrated AFM and waveguide TIRF microscopy. [PDF]

, 2014
Membrane ion channels regulate key cellular functions and their activity is dependent on their 3D structure. Atomic force microscopy (AFM) images 3D structure of membrane channels placed on a solid substrate.
Arce, Fernando Teran, Cohen, Daniel A, Lal, Ratnesh, Patel, Nirav R, Quist, Arjan P, Ramachandran, Srinivasan   +5 more
core   +2 more sources

Design and Characterization of a Human Monoclonal Antibody that Modulates Mutant Connexin 26 Hemichannels Implicated in Deafness and Skin Disorders [PDF]

, 2017
Background: Mutations leading to changes in properties, regulation, or expression of connexin-made channels have been implicated in 28 distinct human hereditary diseases.
Andrea Carrer, Anna M. Salvatore, Anselmi, Barbas, Barbas, Beck, Bedner, Beltramello, Bennett, Berendsen, Best, Bosen, Bosen, Boukamp, Breitling, Brenke, Bruzzone, Bujak, Burton, Ceriani, Chen, Chiara Nardin, Chiara Peres, Clackson, Clair, Comeau, Damiano Buratto, Darden, De Luca, DeVries, Djalilian, Dupont, Emsley, Esseltine, Essenfelder, Fabio Mammano, Fasciani, Federico Ceriani, Ferdinando Scavizzi, Flavia Mazzarda, Forge, Francesca Bruno, Francesco Zonta, Frenzel, Gaia Ziraldo, Garcia, Garcia, Gerido, Giulia Crispino, Goodenough, Guang Yang, Gumbart, Hernandez, Holliger, Housley, Jackson, Johnson, Jun Liao, Kanaporis, Kopecki, Larkin, Lee, Lee, Lefranc, Leibovici, Lerner, Levit, Liang Xu, Lipes, Maeda, Majumder, Marcello Raspa, Martin, Mavilio, McCafferty, McCoy, Mese, Mhaske, Minor, Murshudov, Niessen, Ortolano, Peixiang Ma, Perisic, Pronk, Remington, Retamal, Richard A. Lerner, Riquelme, Rodriguez, Rodriguez-Boulan, Saez, Saez, Sanchez, Sanchez, Schutz, Schutz, Shanshan Wang, Sheng Li, Sichun Xie, Srinivas, Stauffer, Stong, Tamai, Thomas, Tolar, Tritsch, Uitto, Veronica Zorzi, Wang, Wangemann, Weber, Wei Wang, Wilcox, Wingard, Wong, Wu, Xiao Liu, Xuemei Yang, Youjun Chu, Zhang, Zhao, Zhao, Zhihu Qu, Zong, Zonta   +125 more
core   +6 more sources

Gap Junctions and Hemichannels Composed of Connexins and Pannexins Mediate the Secondary Brain Injury Following Intracerebral Hemorrhage

Biology, 2021
Intracerebral hemorrhage (ICH) is a devastating disease with high mortality and morbidity; the mortality rate ranges from 40% at 1 month to 54% at 1 year; only 12–39% achieve good outcomes and functional independence.
Yan Zhang, Suliman Khan, Yang Liu, Rabeea Siddique, Ruiyi Zhang, Voon Wee Yong, Mengzhou Xue   +6 more
doaj   +1 more source

What's the Function of Connexin 32 in the Peripheral Nervous System? [PDF]

, 2018
Connexin 32 (Cx32) is a fundamental protein in the peripheral nervous system (PNS) as its mutations cause the X-linked form of Charcot-Marie-Tooth disease (CMT1X), the second most common form of hereditary motor and sensory neuropathy and a demyelinating
Bortolozzi, Mario
core   +1 more source

Possible role of hemichannels in cancer [PDF]

Frontiers in Physiology, 2014
In humans, connexins (Cxs) and pannexins (Panxs) are the building blocks of hemichannels. These proteins are frequently altered in neoplastic cells and have traditionally been considered as tumor suppressors. Alteration of Cxs and Panxs in cancer cells can be due to genetic, epigenetic and post-transcriptional/post-translational events.
Kurt Alex Schalper, Kurt Alex Schalper, Daniel Eduardo Carvajal-Hausdorf, Mauricio P. Oyarzo   +3 more
openaire   +3 more sources

Astroglial Connexins in Neurodegenerative Diseases

Frontiers in Molecular Neuroscience, 2021
Astrocytes play a crucial role in the maintenance of the normal functions of the Central Nervous System (CNS). During the pathogenesis of neurodegenerative diseases, astrocytes undergo morphological and functional remodeling, a process called reactive ...
Xiaomin Huang, Yixun Su, Nan Wang, Hui Li, Zhigang Li, Guowei Yin, Hui Chen, Jianqin Niu, Chenju Yi   +8 more
doaj   +1 more source

The Role of Connexin 43 and Pannexin 1 During Acute Inflammation

Frontiers in Physiology, 2020
During acute inflammation, the recruitment of leukocytes from the blood stream into the inflamed tissue is a well-described mechanism encompassing the interaction of endothelial cells with leukocytes allowing leukocytes to reach the site of tissue injury
Petra Kameritsch, Petra Kameritsch, Kristin Pogoda   +2 more
doaj   +1 more source

Simulations on Simple Models of Connexin Hemichannels Indicate That Ca²⁺ Blocking Is Not a Pure Electrostatic Effect

Membranes, 2021
Connexin hemichannels allow the unspecific but regulated interchange of molecules from ions to second messenger and ATP, between the eukariotic cell and its extracellular space.
Felipe Villanelo, Jorge Carrasco, Joaquin Jensen-Flores, Jose Antonio Garate, Tomas Perez-Acle   +4 more
doaj   +1 more source