Results 51 to 60 of about 5,094 (206)

The action of mimetic peptides on connexins protects fibroblasts from the negative effects of ischemia reperfusion

Biology Open, 2015
Connexins have been proposed as a target for therapeutic treatment of a variety of conditions. The main approaches have been by antisense or small peptides specific against connexins.
Beverley J. Glass, Rebecca G. Hu, Anthony R. J. Phillips, David L. Becker   +3 more
doaj   +1 more source

Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability [PDF]

, 2021
Cx43, a major cardiac connexin, forms precursor hemichannels that accrue at the intercalated disc to assemble as gap junctions. While gap junctions are crucial for electrical conduction in the heart, little is known about the potential roles of ...
Lissoni, A., Wang, N., Dries, E., Witschas, K., De Smet, Maarten A.J., Wang, Nan, Rothenberg, Eli, Bultynck, Geert, Schulz, R., Dries, Eef, Delmar, Mario, Lin, X., Nezlobinsky, T., Amoni, Matthew, Leybaert, L., Rothenberg, E., Perez-Hernandez, Marta, Panfilov, Alexander V., Panfilov, A. V., Delmar, M., Nezlobinsky, Timur, Nezlobinskii, Timur, Bultynck, G., Vervliet, T., Lin, Xianming, Sipido, Karin R., Vervliet, Tim, Sipido, K. R., Schulz, Rainer, Witschas, Katja, Leybaert, Luc, Amoni, M., De Smet, Maarten, Panfilov, Alexander, Lissoni, Alessio, Pérez-Hernández, M., de, Smet, M. A. J.   +36 more
core   +1 more source

Diseases associated with leaky hemichannels

Frontiers in Cellular Neuroscience, 2015
Hemichannels (HCs) and gap junction channels (GJCs) formed by protein subunits called connexins (Cxs) are major pathways for intercellular communication. While HCs connect the intracellular compartment with the extracellular milieu, GJCs allow the interchange of molecules between cytoplasm of two contacting cells.
Retamal, Mauricio A., Reyes, Edison P., García, Isaac E., Pinto, Bernardo, Martínez, Agustín D., González, Carlos   +5 more
openaire   +3 more sources

Pannexin channels are not gap junction hemichannels [PDF]

Channels, 2011
Pannexins, a class of membrane channels, bear significant sequence homology with the invertebrate gap junction proteins, innexins and more distant similarities in their membrane topologies and pharmacological sensitivities with the gap junction proteins, connexins. However, the functional role for the pannexin oligomers, or pannexons, is different from
Gina E, Sosinsky, Daniela, Boassa, Rolf, Dermietzel, Heather S, Duffy, Dale W, Laird, Brian, MacVicar, Christian C, Naus, Silvia, Penuela, Eliana, Scemes, David C, Spray, Roger J, Thompson, Hong-Bo, Zhao, Gerhard, Dahl   +12 more
openaire   +2 more sources

Extracellular cysteine in connexins: role as redox sensors

Frontiers in Physiology, 2016
Connexin-based channels comprise hemichannels and gap junction channels. The opening of hemichannels allow for the flux of ions and molecules from the extracellular space into the cell and vice versa.
Mauricio Antonio Retamal, Isaac E García, Bernardo ePinto, Amaury ePupo, David eBaez-Nieto, Jimmy eStehberg, RODRIGO eDEL RIO, Carlos eGonzalez   +7 more
doaj   +1 more source

Connexin43 hemichannel block protects against the development of diabetic retinopathy signs in a mouse model of the disease.

, 2023
Diabetic retinopathy (DR) is a vascular disease of the neuroretina characterised by hyperglycaemia and inflammation. Current DR therapies target late-stage vascular defects and there is evidence to suggest that they contribute to geographic atrophy and ...
Bould, Sarah, Green, Colin R, Rupenthal, Ilva D, Mugisho, Odunayo O, Acosta, Monica L, Squirrell, David M, Danesh-Meyer, Helen V, Zhang, Jie   +7 more
core   +1 more source

Pannexin-1 Modulates Inhibitory Transmission and Hippocampal Synaptic Plasticity

Biomolecules, 2023
Pannexin-1 (Panx1) hemichannel is a non-selective transmembrane channel that may play important roles in intercellular signaling by allowing the permeation of ions and metabolites, such as ATP. Although recent evidence shows that the Panx1 hemichannel is
Francisca García-Rojas, Carolina Flores-Muñoz, Odra Santander, Pamela Solis, Agustín D. Martínez, Álvaro O. Ardiles, Marco Fuenzalida   +6 more
doaj   +1 more source

Long-lasting remodeling of astrocytes in an Scna1^+/- mouse model of Dravet syndrome. [PDF]

Epilepsia
Abstract Objective Dravet syndrome (DS) is a prototypical developmental and epileptic encephalopathy caused by mutations in the SCN1A gene, leading to loss of function of the voltage‐gated sodium channel Naᵥ1.1. The latter causes early onset drug‐resistant seizures and enduring cognitive and behavioral deficits.
Genin A, Janvier A, Moujellil-Legagneur T, Blaquière M, Chaussy A, Privé R, Duprat F, Mantegazza M, Audinat E, Marchi N, Cresto N.   +10 more
europepmc   +2 more sources

4-Hydroxynonenal induces Cx46 hemichannel inhibition through its carbonylation

, 2020
Hemichannels formed by connexins mediate the exchange of ions and signaling molecules between the cytoplasm and the extracellular milieu. Under physiological conditions hemichannels have a low open probability, but in certain pathologies their open ...
Peña, Francisca, Quintana, Daisy, Altenberg, Guillermo A., Stehberg, Jimmy, Fernández-Olivares, Ainoa, Fiori, Mariana C., Linsambarth, Sergio, Retamal, Mauricio   +7 more
core   +1 more source

Adenosine—A Regulator of Human Testicular Peritubular Cells

Andrology, EarlyView.
ABSTRACT Background Extracellular purines, in particular ATP and adenosine, are regulators of physiological and pathophysiological processes throughout the human body. Roles in the human testis are emerging and include actions on peritubular cells, which form the wall of seminiferous tubules.
Lina Scholz, Annika Liebich, Youli Stepanov, Jan B. Stöckl, Mirko Peitzsch, Michaela Schneider, Julia Schneider, Nicole Kreitmair, Matthias Trottmann, Frank‐Michael Köhn, Jovica Ninkovic, Thomas Fröhlich, Artur Mayerhofer   +12 more
wiley   +1 more source