Results 51 to 60 of about 4,743 (216)
Collagen I Modifies Connexin?43 Hemichannel Activity via Integrin ?2?1 Binding in TGF?1?Evoked Renal Tubular Epithelial Cells [PDF]
, 2021 Chronic Kidney Disease (CKD) is associated with sustained inflammation and progressive fibrosis, changes that have been linked to altered connexin hemichannel?mediated release of adenosine triphosphate (ATP).
Claire Hills (17159905) +5 more
core +2 more sources
Dye-uptake Experiment through Connexin Hemichannels
Bio-Protocol, 2014 Connexins (Cxs) are integral membrane proteins of vertebrates that associate to form hexameric transmembrane channels, named hemichannels. Twenty-one Cx types have been described, which are named according to their molecular weight.
Andrea Puhar, Philippe Sansonetti
doaj +1 more source
Connexin 43 in Mitochondria: What Do We Really Know About Its Function?
Frontiers in Physiology, 2022 Connexins are known for their ability to mediate cell-cell communication via gap junctions and also form hemichannels that pass ions and molecules over the plasma membrane when open.
Kerstin Boengler +3 more
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Connexin 43 Hemichannels Are Permeable to ATP [PDF]
The Journal of Neuroscience, 2008 Astrocytes are electrically nonexcitable cells that communicate by means of Ca2+signaling. Long-distance intercellular Ca2+waves are initiated by release of ATP and activation of purinergic receptors on nearby cells. Previous studies have implicated connexin 43 (Cx43) in ATP release, but definitive proof that ATP exits through Cx43 hemichannels does ...
Jian, Kang +6 more
openaire +2 more sources
image_1_Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function.jpeg [PDF]
, 2018 The present work was done to elucidate whether hemichannels of a cell line derived from endothelial cells are affected by pro-inflammatory conditions (high glucose and IL-1β/TNF-α) known to lead to vascular dysfunction.
Victoria Velarde (5632436) +10 more
core +1 more source
Pannexin channels are not gap junction hemichannels [PDF]
Channels, 2011 Pannexins, a class of membrane channels, bear significant sequence homology with the invertebrate gap junction proteins, innexins and more distant similarities in their membrane topologies and pharmacological sensitivities with the gap junction proteins, connexins. However, the functional role for the pannexin oligomers, or pannexons, is different from
Gina E, Sosinsky +12 more
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Biology Open, 2015 Connexins have been proposed as a target for therapeutic treatment of a variety of conditions. The main approaches have been by antisense or small peptides specific against connexins.
Beverley J. Glass +3 more
doaj +1 more source
Characterization of Nonjunctional Hemichannels in Caterpillar Cells [PDF]
Journal of Insect Science, 2011 Recent studies have demonstrated that hemichannels, which form gap junctions when paired from apposing cells, may serve additional roles when unpaired including cell adhesion and paracrine communication. Hemichannels in mammals are formed by connexins or pannexins, while in insects they are formed by pannexin homologues termed innexins.
Luo, Kaijun, Turnbull, Matthew W.
openaire +2 more sources
Putative hemichannel currents were increased in the HeLa cells-expressing AF-linked Cx40 mutants. [PDF]
, 2014 Voltage clamp ramp protocol (−40 to 110 mV) was used to study currents under divalent cation containing saline (DCC, black traces) and the divalent-cation free saline (DCF, red traces).
Xiaoling Tong (141534) +4 more
core +1 more source
Extracellular cysteine in connexins: role as redox sensors
Frontiers in Physiology, 2016 Connexin-based channels comprise hemichannels and gap junction channels. The opening of hemichannels allow for the flux of ions and molecules from the extracellular space into the cell and vice versa.
Mauricio Antonio Retamal +7 more
doaj +1 more source