Results 21 to 30 of about 4,743 (216)

Possible role of hemichannels in cancer [PDF]

Frontiers in Physiology, 2014
In humans, connexins (Cxs) and pannexins (Panxs) are the building blocks of hemichannels. These proteins are frequently altered in neoplastic cells and have traditionally been considered as tumor suppressors. Alteration of Cxs and Panxs in cancer cells can be due to genetic, epigenetic and post-transcriptional/post-translational events.
Kurt Alex Schalper, Kurt Alex Schalper, Daniel Eduardo Carvajal-Hausdorf, Mauricio P. Oyarzo   +3 more
openaire   +3 more sources

Hemichannels; from the molecule to the function [PDF]

Frontiers in Physiology, 2014
Coordinated cell interactions are required to accomplish several complex and dynamic tasks observed in several tissues. Cell function may be coordinated by cell-to-cell communication through gap junctions channels (GJCs). These channels are formed by the serial docking of two hemichannels, which in turn are formed by six protein subunits called ...
Retamal, M., Sáez, Juan Carlos
openaire   +4 more sources

Long-lasting remodeling of astrocytes in an Scna1^+/- mouse model of Dravet syndrome. [PDF]

Epilepsia
Abstract Objective Dravet syndrome (DS) is a prototypical developmental and epileptic encephalopathy caused by mutations in the SCN1A gene, leading to loss of function of the voltage‐gated sodium channel Naᵥ1.1. The latter causes early onset drug‐resistant seizures and enduring cognitive and behavioral deficits.
Genin A, Janvier A, Moujellil-Legagneur T, Blaquière M, Chaussy A, Privé R, Duprat F, Mantegazza M, Audinat E, Marchi N, Cresto N.   +10 more
europepmc   +2 more sources

Connexin43 hemichannel block protects against the development of diabetic retinopathy signs in a mouse model of the disease. [PDF]

, 2023
Diabetic retinopathy (DR) is a vascular disease of the neuroretina characterised by hyperglycaemia and inflammation. Current DR therapies target late-stage vascular defects and there is evidence to suggest that they contribute to geographic atrophy and ...
Bould, Sarah, Green, Colin R, Rupenthal, Ilva D, Mugisho, Odunayo O, Acosta, Monica L, Squirrell, David M, Danesh-Meyer, Helen V, Zhang, Jie   +7 more
core   +1 more source

Hemichannel openings due to dephosphorylation. [PDF]

, 2012
(A) After adding 10 units of CIP to the chamber, Cx43 hemichannel mediated increases in conductance were observed. (B) CIP did not cause increases in conductance when Cx43 proteoliposomes that were previously dephosphorylated using CIP, were fused to the
Carlo Montemagno (125840), Jacob Todd (125838), David Wendell (125842), Cole Brokamp (125837)   +3 more
core   +1 more source

Connexin hemichannels as candidate targets for cardioprotective and anti-arrhythmic treatments

The Journal of Clinical Investigation, 2023
Connexins are crucial cardiac proteins that form hemichannels and gap junctions. Gap junctions are responsible for the propagation of electrical and chemical signals between myocardial cells and cells of the specialized conduction system in order to ...
Luc Leybaert, Maarten A.J. De Smet, Alessio Lissoni, Rosalie Allewaert, H. Llewelyn Roderick, Geert Bultynck, Mario Delmar, Karin R. Sipido, Katja Witschas   +8 more
doaj   +1 more source

Pathogenic connexin-31 forms constitutively active hemichannels to promote necrotic cell death. [PDF]

PLoS ONE, 2012
Mutations in Connexin-31 (Cx31) are associated with multiple human diseases including erythrokeratodermia variabilis (EKV). The molecular action of Cx31 pathogenic mutants remains largely elusive.
Jingwei Chi, Li Li, Mujun Liu, Jieqiong Tan, Chengyuan Tang, Qian Pan, Danling Wang, Zhuohua Zhang   +7 more
doaj   +1 more source

Adhesive properties of connexin hemichannels [PDF]

Glia, 2008
AbstractGap junctions are intercellular channels formed by hemichannels (or connexons) from two neighboring cells. Hemichannels, which are composed of proteins called connexins, can function as conduits of ATP and glutamate, and interact with adhesion molecules and other signaling elements.
M L, Cotrina, J H-C, Lin, M, Nedergaard
openaire   +2 more sources

Effects of Carbamazepine, Lacosamide and Zonisamide on Gliotransmitter Release Associated with Activated Astroglial Hemichannels

Pharmaceuticals, 2020
Recent studies using the genetic partial epilepsy model have demonstrated that hyperfunction of astroglial hemichannels contributes to pathomechanism of epileptic seizure.
Kouji Fukuyama, Yuto Ueda, Motohiro Okada   +2 more
doaj   +1 more source

Astroglial Connexins in Neurodegenerative Diseases

Frontiers in Molecular Neuroscience, 2021
Astrocytes play a crucial role in the maintenance of the normal functions of the Central Nervous System (CNS). During the pathogenesis of neurodegenerative diseases, astrocytes undergo morphological and functional remodeling, a process called reactive ...
Xiaomin Huang, Yixun Su, Nan Wang, Hui Li, Zhigang Li, Guowei Yin, Hui Chen, Jianqin Niu, Chenju Yi   +8 more
doaj   +1 more source