Connexin 43 and Pannexin 1 hemichannels as endogenous regulators of innate immunity in sepsis [PDF]
Frontiers in ImmunologySepsis is a life-threatening organ dysfunction resulting from a dysregulated host response to infections that is initiated by the body’s innate immune system. Nearly a decade ago, we discovered that bacterial lipopolysaccharide (LPS) and serum amyloid A (
Jianhua Li +9 more
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Hemichannels: new roles in astroglial function [PDF]
Frontiers in Physiology, 2014 The role of astrocytes in brain function has evolved over the last decade, from support cells to active participants in the neuronal synapse through the release of gliotransmitters.
Jimmy eStehberg, Juan Andrés Orellana
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The connexin hemichannel inhibitor D4 produces rapid antidepressant-like effects in mice
Journal of Neuroinflammation, 2023 Depression is a common mood disorder characterized by a range of clinical symptoms, including prolonged low mood and diminished interest. Although many clinical and animal studies have provided significant insights into the pathophysiology of depression,
Huanhuan Li +4 more
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Cellular and Molecular Life Sciences, 2023 Increasing evidence implicates astrocytic dysfunction in Alzheimer’s disease (AD), a neurodegenerative disorder characterised by progressive cognitive loss.
D. Madeira +5 more
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Frontiers in Chemistry, 2022 Peptide5 is a 12–amino acid mimetic peptide that corresponds to a region of the extracellular loop 2 (EL2) of connexin43. Peptide5 regulates both cellular communication with the cytoplasm (hemichannels) and cell-to-cell communication (gap junctions), and
Sin Hang Crystal Chan +9 more
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Blockade of gap junction hemichannel suppresses disease progression in mouse models of amyotrophic lateral sclerosis and Alzheimer's disease. [PDF]
PLoS ONE, 2011 Glutamate released by activated microglia induces excitotoxic neuronal death, which likely contributes to non-cell autonomous neuronal death in neurodegenerative diseases, including amyotrophic lateral sclerosis and Alzheimer's disease.
Hideyuki Takeuchi +18 more
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Targeting inflammation in cardiometabolic disease: Icosapent ethyl modulates monocyte-derived macrophages isolated from patients with cardiovascular disease with or without type 2 diabetes. [PDF]
Diabet MedAbstract Aims Despite intensive lipid‐lowering therapy, individuals with atherosclerotic cardiovascular disease (ASCVD) exhibit residual inflammatory risk, which drives recurrent cardiovascular events. This risk is amplified in type 2 diabetes mellitus (T2DM), where a pro‐inflammatory milieu accelerates atherogenesis. Monocyte‐derived macrophages (MDMs)
Ward JK +4 more
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021 The antiepileptic/anticonvulsive action of brivaracetam is considered to occur via modulation of synaptic vesicle protein 2A (SV2A); however, the pharmacological mechanisms of action have not been fully characterised.
M. Okada +3 more
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Disruption in connexin-based communication is associated with intracellular Ca²⁺ signal alterations in astrocytes from Niemann-Pick type C mice. [PDF]
PLoS ONE, 2013 Reduced astrocytic gap junctional communication and enhanced hemichannel activity were recently shown to increase astroglial and neuronal vulnerability to neuroinflammation.
Pablo J Sáez +9 more
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Cryo-EM structure of an open conformation of a gap junction hemichannel in lipid bilayer nanodiscs.
Structure, 2021 To mediate cell-to-cell communication via gap junction channels (GJCs), connexins (Cx) traffic as hexameric hemichannels to the plasma membrane, which dock end-to-end between adjacent cell membranes, thereby forming a dodecameric intercellular conduit ...
Ali K. Khan +4 more
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