Results 11 to 20 of about 4,743 (216)
RhoA GTPase switch controls Cx43-hemichannel activity through the contractile system. [PDF]
PLoS ONE, 2012 ATP-dependent paracrine signaling, mediated via the release of ATP through plasma membrane-embedded hemichannels of the connexin family, coordinates a synchronized response between neighboring cells.
Raf Ponsaerts +7 more
doaj +3 more sources
Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function [PDF]
Frontiers in Immunology, 2018 The present work was done to elucidate whether hemichannels of a cell line derived from endothelial cells are affected by pro-inflammatory conditions (high glucose and IL-1β/TNF-α) known to lead to vascular dysfunction.
Juan C. Sáez +12 more
doaj +2 more sources
Hemichannel and Junctional Properties of Connexin 50 [PDF]
Biophysical Journal, 2002 Lens fiber connexins, cx50 and cx46 (alpha3 and alpha8), belong to a small subset of connexins that can form functional hemichannels in nonjunctional membranes. Knockout of either cx50 or cx46 results in a cataract, so the properties of both connexins are likely essential for proper physiological functioning of the lens.
Beahm, Derek L., Hall, James E.
openaire +4 more sources
Restraint stress increases hemichannel activity in hippocampal glial cells and neurons [PDF]
Frontiers in Cellular Neuroscience, 2015 Stress affects brain areas involved in learning and emotional responses, which may contribute in the development of cognitive deficits associated with major depression.
Juan Andrés Orellana +6 more
doaj +2 more sources
Atrial fibrillation-linked germline GJA5/connexin40 mutants showed an increased hemichannel function. [PDF]
PLoS ONE, 2014 Mutations in GJA5 encoding the gap junction protein connexin40 (Cx40) have been linked to lone atrial fibrillation. Some of these mutants result in impaired gap junction function due to either abnormal connexin localization or impaired gap junction ...
Yiguo Sun +4 more
doaj +2 more sources
Combined Inhibition of TRPM4/NMDA Receptor Complex and Extrasynaptic NMDA Receptors Is Candidate Therapeutic Target for Suppression of Epileptic Seizures and Improvement of Cognitive Impairments. [PDF]
Pharmacol Res PerspectABSTRACT Cognitive impairments are important therapeutic targets in epilepsy medication; however, effective pharmacological treatments for epilepsy patients with comorbid cognitive impairment have not been established. Effects of chronic administration of MK‐801 (noncompetitive NMDA receptor inhibitor), memantine (low‐affinity extrasynaptic‐NMDA ...
Okada M, Okubo R, Oka T, Motomura E.
europepmc +2 more sources
Model-based evaluation of connexin hemichannel permeability. [PDF]
Comput Struct Biotechnol JConnexin (Cx) hemichannels form intercellular gap junction channels but can also function independently. These large-pore channels are permeable not only to ions but also to small signalling molecules and metabolites. This functional property is relevant
Kraujalis T +7 more
europepmc +2 more sources
Following Tracks of Hemichannels [PDF]
Cell Communication & Adhesion, 2003 It has been suggested that plasma membrane-bound hemichannels perform physiological and pathophysiological functions per se. Such functions require the presence of hemichannels on the cell surface and their accessibility to the extracellular environment for at least some limited period of time.
Rolf, Dermietzel +3 more
openaire +3 more sources
Hunting for connexin hemichannels [PDF]
FEBS Letters, 2014 Connexin hemichannels (connexons) are building blocks of gap junctions but also function as free unapposed channels, which has become an active field of research. Defining functions of hemichannels and their involvement in any biological event requires ruling out possible participation of other channels that share biophysical and regulatory properties,
Saez, Juan C., Leybaert, Luc
openaire +4 more sources
Connexin hemichannels in the lens [PDF]
Frontiers in Physiology, 2014 The normal function and survival of cells in the avascular lens is facilitated by intercellular communication through an extensive network of gap junctions formed predominantly by three connexins (Cx43, Cx46, and Cx50). In expression systems, these connexins can all induce hemichannel currents, but other lens proteins (e.g., pannexin1) can also induce ...
Beyer, Eric C., Berthoud, Viviana M.
openaire +3 more sources