Results 11 to 20 of about 5,094 (206)
RhoA GTPase switch controls Cx43-hemichannel activity through the contractile system. [PDF]
PLoS ONE, 2012 ATP-dependent paracrine signaling, mediated via the release of ATP through plasma membrane-embedded hemichannels of the connexin family, coordinates a synchronized response between neighboring cells.
Raf Ponsaerts +7 more
doaj +2 more sources
Frontiers in Immunology, 2018 The present work was done to elucidate whether hemichannels of a cell line derived from endothelial cells are affected by pro-inflammatory conditions (high glucose and IL-1β/TNF-α) known to lead to vascular dysfunction.
Juan C. Sáez +12 more
doaj +2 more sources
Hemichannel and Junctional Properties of Connexin 50 [PDF]
Biophysical Journal, 2002 Lens fiber connexins, cx50 and cx46 (α3 and α8), belong to a small subset of connexins that can form functional hemichannels in nonjunctional membranes. Knockout of either cx50 or cx46 results in a cataract, so the properties of both connexins are likely
Hall, James E., Beahm, Derek L.
core +4 more sources
Restraint stress increases hemichannel activity in hippocampal glial cells and neurons [PDF]
Frontiers in Cellular Neuroscience, 2015 Stress affects brain areas involved in learning and emotional responses, which may contribute in the development of cognitive deficits associated with major depression.
Juan Andrés Orellana +6 more
doaj +2 more sources
Hemichannels: new roles in astroglial function [PDF]
Frontiers in Physiology, 2014 The role of astrocytes in brain function has evolved over the last decade, from support cells to active participants in the neuronal synapse through the release of gliotransmitters.
Jimmy eStehberg, Juan Andrés Orellana
doaj +4 more sources
PLoS ONE, 2014 Mutations in GJA5 encoding the gap junction protein connexin40 (Cx40) have been linked to lone atrial fibrillation. Some of these mutants result in impaired gap junction function due to either abnormal connexin localization or impaired gap junction ...
Yiguo Sun +4 more
doaj +2 more sources
Model-based evaluation of connexin hemichannel permeability. [PDF]
Comput Struct Biotechnol JConnexin (Cx) hemichannels form intercellular gap junction channels but can also function independently. These large-pore channels are permeable not only to ions but also to small signalling molecules and metabolites. This functional property is relevant
Kraujalis T +7 more
europepmc +3 more sources
Combined Inhibition of TRPM4/NMDA Receptor Complex and Extrasynaptic NMDA Receptors Is Candidate Therapeutic Target for Suppression of Epileptic Seizures and Improvement of Cognitive Impairments. [PDF]
Pharmacol Res PerspectABSTRACT Cognitive impairments are important therapeutic targets in epilepsy medication; however, effective pharmacological treatments for epilepsy patients with comorbid cognitive impairment have not been established. Effects of chronic administration of MK‐801 (noncompetitive NMDA receptor inhibitor), memantine (low‐affinity extrasynaptic‐NMDA ...
Okada M, Okubo R, Oka T, Motomura E.
europepmc +2 more sources
, 2023 Introduction: Our previous findings link connexin-43 (Cx43)-hemichannel mediated ATP release to an increase in the nod-like receptor protein-3 (NLRP3) inflammasome, via nuclear factor kappa-B (NF?B)-mediated priming and purinergic P2X7 receptor (P2X7R ...
Claire Hills (17159905) +3 more
core +5 more sources
Following Tracks of Hemichannels [PDF]
Cell Communication & Adhesion, 2003 It has been suggested that plasma membrane-bound hemichannels perform physiological and pathophysiological functions per se. Such functions require the presence of hemichannels on the cell surface and their accessibility to the extracellular environment for at least some limited period of time.
Rolf, Dermietzel +3 more
openaire +3 more sources