Results 31 to 40 of about 8,652 (209)

Connexin hemichannels as candidate targets for cardioprotective and anti-arrhythmic treatments

The Journal of Clinical Investigation, 2023
Connexins are crucial cardiac proteins that form hemichannels and gap junctions. Gap junctions are responsible for the propagation of electrical and chemical signals between myocardial cells and cells of the specialized conduction system in order to ...
Luc Leybaert, Maarten A.J. De Smet, Alessio Lissoni, Rosalie Allewaert, H. Llewelyn Roderick, Geert Bultynck, Mario Delmar, Karin R. Sipido, Katja Witschas   +8 more
doaj   +1 more source

Rational design of new NO and redox sensitivity into connexin26 hemichannels [PDF]

Open Biology, 2015
CO2 directly opens hemichannels of connexin26 (Cx26) by carbamylating K125, thereby allowing salt bridge formation with R104 of the neighbouring subunit in the connexin hexamer.
Louise Meigh, Daniel Cook, Jie Zhang, Nicholas Dale   +3 more
doaj   +1 more source

Connexin and pannexin (hemi)channels in the liver

Frontiers in Physiology, 2014
The liver was among the first organs in which connexin proteins have been identified. Hepatocytes harbour connexin32 and connexin26, while non-parenchymal liver cells typically express connexin43.
Michaël eMaes, Elke eDecrock, Bruno eCogliati, André G Oliveira, Pedro E Marques, Maria Lucia eZaidan Dagli, Gustavo B Menezes, Gregory eMennecier, Luc eLeybaert, Tamara eVanhaecke, Vera eRogiers, Mathieu eVinken   +11 more
doaj   +1 more source

Hemichannel-mediated release of lactate [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2015
In the central nervous system lactate contributes to the extracellular pool of readily available energy substrates and may also function as a signaling molecule which mediates communication between glial cells and neurons. Monocarboxylate transporters are believed to provide the main pathway for lactate transport across the ...
Karagiannis, Anastassios, Sylantyev, Sergiy, Hadjihambi, Anna, Hosford, Patrick S, Kasparov, Sergey, Gourine, Alexander V   +5 more
openaire   +4 more sources

Gap junction hemichannels in astrocytes of the CNS [PDF]

Acta Physiologica Scandinavica, 2003
AbstractConnexins are protein subunits that oligomerize into hexamers called connexons, gap junction hemichannels or just hemichannels. Because some gap junction channels are permeable to negatively and/or positively charged molecules up to ∼ 1kDa in size, it was thought that hemichannels should not open to the extracellular space.
Saez, JC, Contreras, JE, Bukauskas, FF, Retamal, MA, Bennett, MVL   +4 more
openaire   +4 more sources

SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca2+ dynamics

Biological Research, 2023
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the ongoing coronavirus disease 2019 (COVID-19). An aspect of high uncertainty is whether the SARS-CoV-2 per se or the systemic inflammation induced by viral infection ...
Juan Prieto-Villalobos, Claudia M. Lucero, Maximiliano Rovegno, Gonzalo I. Gómez, Mauricio A. Retamal, Juan A. Orellana   +5 more
doaj   +1 more source

Contribution of Connexin Hemichannels to the Decreases in Cell Viability Induced by Linoleic Acid in the Human Lens Epithelial Cells (HLE-B3)

Frontiers in Physiology, 2020
Connexin (Cx) proteins form gap junction channels (GJC) and hemichannels that a allow bidirectional flow of ions and metabolites between the cytoplasm and extracellular space, respectively.
Vania A. Figueroa, Vania A. Figueroa, Oscar Jara, Carolina A. Oliva, Marcelo Ezquer, Fernando Ezquer, Mauricio A. Retamal, Mauricio A. Retamal, Mauricio A. Retamal, Agustín D. Martínez, Guillermo A. Altenberg, Guillermo A. Altenberg, Aníbal A. Vargas, Aníbal A. Vargas   +13 more
doaj   +1 more source

Extracellular Cysteines Are Critical to Form Functional Cx46 Hemichannels [PDF]

, 2022
Connexin (Cxs) hemichannels participate in several physiological and pathological processes, but the molecular mechanisms that control their gating remain elusive.
Stehberg, Jimmy, Juan Francisco Calderón, Calderón, Juan Francisco, Ainoa Fernández-Olivares, Fernández Olivares, Ainoa, Fernández, Ainoa, Mauricio A. Retamal, Fiori, Mariana, Jimmy Stehberg, Calderón, Juan, Durán Jara, Eduardo, Fiori, Mariana C., Altenberg, Guillermo, Retamal, Mauricio, Durán, Eduardo, Retamal, Mauricio A., Iván Alfaro, Mariana C. Fiori, Guillermo A. Altenberg, Alfaro, Iván, Verdugo, Daniel, Daniel A. Verdugo, Altenberg, Guillermo A., Fernández-Olivares, Ainoa, Eduardo Durán-Jara, Durán-Jara, Eduardo, Verdugo, Daniel A.   +26 more
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Gap Junctions or Hemichannel-Dependent and Independent Roles of Connexins in Fibrosis, Epithelial–Mesenchymal Transitions, and Wound Healing

Biomolecules, 2023
Fibrosis initially appears as a normal response to damage, where activated fibroblasts produce large amounts of the extracellular matrix (ECM) during the wound healing process to assist in the repair of injured tissue. However, the excessive accumulation
Yuting Li, Francisca M. Acosta, Jean X. Jiang   +2 more
doaj   +1 more source

Paracrine signaling through plasma membrane hemichannels [PDF]

, 2012
Plasma membrane hemichannels composed of connexin (Cx) proteins are essential components of gap junction channels but accumulating evidence suggests functions of hemichannels beyond the communication provided by junctional channels.
De Bock, Marijke, Decrock, Elke, Vinken, Mathieu, Bol, Mélissa, Wang, Nan, Leybaert, Luc, Bukauskas, Feliksas F, Bultynck, Geert, Gadicherla, Ashish, Rogiers, Vera, Bukauskas, Feliksas F.   +10 more
core   +1 more source