Results 31 to 40 of about 6,486 (158)
Connexin and pannexin (hemi)channels in the liver
Frontiers in Physiology, 2014 The liver was among the first organs in which connexin proteins have been identified. Hepatocytes harbour connexin32 and connexin26, while non-parenchymal liver cells typically express connexin43.
Michaël eMaes +11 more
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Hemichannel-mediated release of lactate [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2015 In the central nervous system lactate contributes to the extracellular pool of readily available energy substrates and may also function as a signaling molecule which mediates communication between glial cells and neurons. Monocarboxylate transporters are believed to provide the main pathway for lactate transport across the ...
Karagiannis, Anastassios +5 more
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The Role of Connexin Hemichannels in Inflammatory Diseases [PDF]
Biology, 2022 The connexin protein family consists of approximately 20 members, and is well recognized as the structural unit of the gap junction channels that perforate the plasma membranes of coupled cells and, thereby, mediate intercellular communication. Gap junctions are assembled by two preexisting hemichannels on the membranes of apposing cells.
Bo Peng +4 more
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Gap junction hemichannels in astrocytes of the CNS [PDF]
Acta Physiologica Scandinavica, 2003 AbstractConnexins are protein subunits that oligomerize into hexamers called connexons, gap junction hemichannels or just hemichannels. Because some gap junction channels are permeable to negatively and/or positively charged molecules up to ∼ 1kDa in size, it was thought that hemichannels should not open to the extracellular space.
Saez, JC +4 more
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SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca2+ dynamics
Biological Research, 2023 Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the ongoing coronavirus disease 2019 (COVID-19). An aspect of high uncertainty is whether the SARS-CoV-2 per se or the systemic inflammation induced by viral infection ...
Juan Prieto-Villalobos +5 more
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Frontiers in Physiology, 2020 Connexin (Cx) proteins form gap junction channels (GJC) and hemichannels that a allow bidirectional flow of ions and metabolites between the cytoplasm and extracellular space, respectively.
Vania A. Figueroa +13 more
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The role of pannexin hemichannels in inflammation and regeneration [PDF]
Frontiers in Physiology, 2014 Tissue injury involves coordinated systemic responses including inflammatory response, targeted cell migration, cell-cell communication, stem cell activation and proliferation, and tissue inflammation and regeneration. The inflammatory response is an important prerequisite for regeneration.
Helen P. Makarenkova +2 more
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Connexin hemichannels and cell-cell channels: comparison of properties
Brazilian Journal of Medical and Biological Research, 2000 Connexin46 (Cx46) forms functional hemichannels in the absence of contact by an apposed hemichannel and we have used these hemichannels to study gating and permeation at the single channel level with high time resolution.
V.K. Verselis +2 more
doaj +1 more source
Disruption in connexin-based communication is associated with intracellular Ca²⁺ signal alterations in astrocytes from Niemann-Pick type C mice. [PDF]
PLoS ONE, 2013 Reduced astrocytic gap junctional communication and enhanced hemichannel activity were recently shown to increase astroglial and neuronal vulnerability to neuroinflammation.
Pablo J Sáez +9 more
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Biomolecules, 2023 Fibrosis initially appears as a normal response to damage, where activated fibroblasts produce large amounts of the extracellular matrix (ECM) during the wound healing process to assist in the repair of injured tissue. However, the excessive accumulation
Yuting Li +2 more
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