Results 31 to 40 of about 15,292 (254)
Hunting for connexin hemichannels [PDF]
FEBS Letters, 2014 Connexin hemichannels (connexons) are building blocks of gap junctions but also function as free unapposed channels, which has become an active field of research. Defining functions of hemichannels and their involvement in any biological event requires ruling out possible participation of other channels that share biophysical and regulatory properties,
Saez, Juan C., Leybaert, Luc
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Inhibition of Connexin43 hemichannels impairs spatial short-term memory without affecting spatial working memory [PDF]
, 2016 Astrocytes are active players in higher brain function as they can release gliotransmitters, which are essential for synaptic plasticity. Various mechanisms have been proposed for gliotransmission, including vesicular mechanisms as well as non-vesicular ...
Albertini, Giulia +5 more
core +5 more sources
Bone Research, 2021 Mechanical loading opens connexin 43 (Cx43) hemichannels (HCs), leading to the release of bone anabolic molecules, such as prostaglandins, from mechanosensitive osteocytes, which is essential for bone formation and remodeling.
M. Riquelme +3 more
semanticscholar +1 more source
Carboxyfluorescein Dye Uptake to Measure Connexin-mediated Hemichannel Activity in Cultured Cells
Bio-Protocol, 2021 Connexins are membrane bound proteins that facilitate direct and local paracrine mediated cell-to-cell communication through their ability to oligomerise into hexameric hemichannels.
Joe Potter +5 more
doaj +1 more source
Hypertensive Nephropathy: Unveiling the Possible Involvement of Hemichannels and Pannexons
International Journal of Molecular Sciences, 2022 Hypertension is one of the most common risk factors for developing chronic cardiovascular diseases, including hypertensive nephropathy. Within the glomerulus, hypertension causes damage and activation of mesangial cells (MCs), eliciting the production of
Claudia M. Lucero +9 more
semanticscholar +1 more source
GABAergic Regulation of Astroglial Gliotransmission through Cx43 Hemichannels
International Journal of Molecular Sciences, 2022 Gamma-Aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the brain. It is produced by interneurons and recycled by astrocytes. In neurons, GABA activates the influx of Cl- via the GABAA receptor or efflux or K+ via the GABAB receptor,
Ivanka Jiménez-Dinamarca +10 more
semanticscholar +1 more source
An electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels. [PDF]
, 2016 Gap junction channels mediate intercellular signalling that is crucial in tissue development, homeostasis and pathologic states such as cardiac arrhythmias, cancer and trauma.
Abagyan, Ruben +9 more
core +8 more sources
Connexin hemichannels with prostaglandin release in anabolic function of bone to mechanical loading
eLife, 2022 Mechanical stimulation, such as physical exercise, is essential for bone formation and health. Here, we demonstrate the critical role of osteocytic Cx43 hemichannels in anabolic function of bone in response to mechanical loading.
Dezhi Zhao +6 more
doaj +1 more source
Oxidative Stress, Inflammation and Connexin Hemichannels in Muscular Dystrophies
Biomedicines, 2022 Muscular dystrophies (MDs) are a heterogeneous group of congenital neuromuscular disorders whose clinical signs include myalgia, skeletal muscle weakness, hypotonia, and atrophy that leads to progressive muscle disability and loss of ambulation.
A. Gonzalez-Jamett +5 more
semanticscholar +1 more source
Adhesive properties of connexin hemichannels [PDF]
Glia, 2008 AbstractGap junctions are intercellular channels formed by hemichannels (or connexons) from two neighboring cells. Hemichannels, which are composed of proteins called connexins, can function as conduits of ATP and glutamate, and interact with adhesion molecules and other signaling elements.
M L, Cotrina, J H-C, Lin, M, Nedergaard
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