Results 51 to 60 of about 6,538 (174)

Voltage-dependent facilitation of Cx46 hemichannels

American Journal of Physiology-Cell Physiology, 2010
Gap junction channels are formed by two hemichannels in series (one from each neighboring cell), which are in turn connexin hexamers. Under normal conditions, hemichannels at the plasma membrane are mostly closed but can be opened by changes in membrane voltage, extracellular divalent ion concentration, phosphorylation, pH, and redox potential ...
Retamal, Mauricio A., Yin, ShengYong, Altenberg, Guillermo A., Reuss, Luis   +3 more
openaire   +5 more sources

Interactive segmentation of membrane and membrane‐mimic densities in cryo‐EM maps

Acta Crystallographica Section D, Volume 82, Issue 8, Page 848-861, August 2026.
SURFER performs automated segmentation of contextual membrane and membrane‐mimic density in cryo‐EM maps to enable robust separation of macromolecular signal from surrounding detergent or lipid–membrane features. It is conveniently distributed as a plugin for UCSF ChimeraX, allowing interactive application within standard map‐visualization workflows ...
Alok Bharadwaj, Lotte Veerbeek, Arjen Jakobi   +2 more
wiley   +1 more source

Membrane‐Associated Biomolecules for Synthetic Cell Signalling

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Membrane‐associated proteins and nucleic acids are transforming synthetic cell communication, unlocking applications in biosensing, therapeutics, and tissue engineering. This review explores how these biomolecules enable complementary strategies for cell tethering, vesicle generation and fusion, signal transmission, and signal transduction.
Chelsea Dack, Bingkun Li, Charlie Newell, Michael J. Booth   +3 more
wiley   +1 more source

Modulation of Cx46 hemichannels by nitric oxide

American Journal of Physiology-Cell Physiology, 2009
Gap-junction hemichannels are composed of six protein subunits (connexins). Undocked hemichannels contribute to physiological autocrine/paracrine cell signaling, including release of signaling molecules, cell-volume regulation, and glucose uptake.
Retamal, Mauricio A., Yin, ShengYong, Altenberg, Guillermo A., Reuss, Luis   +3 more
openaire   +5 more sources

Astrocyte Mechanobiology: Linking Biomechanical Forces to Biochemical Signaling in the Central Nervous System

Glia, Volume 74, Issue 7, July 2026.
Astrocytes are key sensors and transducers of biomechanical stimuli within the central nervous system. Astrocyte development is highly dependent on mechanical stimuli such as surrounding tissue stiffness and biomechanical strain. Mechanosensory pathways including integrins, connexins and pannexins, and mechanosensitive channels regulate astrocyte ...
Ana N. Strat, Alima Ahmed, Mariano Viapiano, Preethi S. Ganapathy   +3 more
wiley   +1 more source

Hemichannel and Junctional Properties of Connexin 50 [PDF]

Biophysical Journal, 2002
Lens fiber connexins, cx50 and cx46 (alpha3 and alpha8), belong to a small subset of connexins that can form functional hemichannels in nonjunctional membranes. Knockout of either cx50 or cx46 results in a cataract, so the properties of both connexins are likely essential for proper physiological functioning of the lens.
Beahm, Derek L., Hall, James E.
openaire   +2 more sources

Acute activation of hemichannels by ethanol leads to Ca2+-dependent gliotransmitter release in astrocytes

Frontiers in Cell and Developmental Biology
Multiple studies have demonstrated that acute ethanol consumption alters brain function and cognition. Nevertheless, the mechanisms underlying this phenomenon remain poorly understood.
Gonzalo I. Gómez, Claudia García-Rodríguez, Jesús E. Marillán, Sergio A. Vergara, Tanhia F. Alvear, Arantza Farias-Pasten, Juan C. Sáez, Mauricio A. Retamal, Maximiliano Rovegno, Fernando C. Ortiz, Juan A. Orellana   +10 more
doaj   +1 more source

Molecular Mechanism of the IRF1/NFE2L1‐DT/ALKBH5/Cx43 Axis in Radiation‐Induced Injury in Vascular Endothelial Cells Through Pyroptosis

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 7, July 2026.
ABSTRACT Radiotherapy effectively eradicates tumor cells but can also trigger pyroptotic damage in vascular endothelial cells. This study investigates the role of interferon regulatory factor 1 (IRF1) in radiation‐induced endothelial injury, aiming to provide mechanistic insights for optimizing radiotherapy.
Chen Li, Jia‐Wen Yang, Yong‐Rui Jia, Jie Zhang, Qiao Gou   +4 more
wiley   +1 more source

Calcium Regulation of Connexin Hemichannels

International Journal of Molecular Sciences
Connexin hemichannels (HCs) expressed at the plasma membrane of mammalian cells are of paramount importance for intercellular communication. In physiological conditions, HCs can form gap junction (GJ) channels, providing a direct diffusive path between neighbouring cells.
Erva Bayraktar, Diego Lopez-Pigozzi, Mario Bortolozzi   +2 more
openaire   +3 more sources

Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage

Biological Research
Background Alcohol, a widely abused drug, significantly diminishes life quality, causing chronic diseases and psychiatric issues, with severe health, societal, and economic repercussions. Previously, we demonstrated that non-voluntary alcohol consumption
Gonzalo I. Gómez, Tanhia F. Alvear, Daniela A. Roa, Arantza Farias-Pasten, Sergio A. Vergara, Luis A. Mellado, Claudio J. Martinez-Araya, Juan Prieto-Villalobos, Claudia García-Rodríguez, Natalia Sánchez, Juan C. Sáez, Fernando C. Ortíz, Juan A. Orellana   +12 more
doaj   +1 more source