Results 51 to 60 of about 15,292 (254)
What's the Function of Connexin 32 in the Peripheral Nervous System? [PDF]
, 2018 Connexin 32 (Cx32) is a fundamental protein in the peripheral nervous system (PNS) as its mutations cause the X-linked form of Charcot-Marie-Tooth disease (CMT1X), the second most common form of hereditary motor and sensory neuropathy and a demyelinating
Bortolozzi, Mario
core +1 more source
Cryopreservation of equine oocytes: looking into the crystal ball [PDF]
, 2020 In vitro embryo production has evolved rapidly in the horse over the past decade, but blastocyst rates from vitrified equine oocytes remain quite poor and further research is needed to warrant application.
Angel Velez, Daniel +4 more
core +2 more sources
Antioxidants, 2021 The lens is continuously exposed to oxidative stress insults, such as ultraviolet radiation and other oxidative factors, during the aging process. The lens possesses powerful oxidative stress defense systems to maintain its redox homeostasis, one of ...
Yumeng Quan +4 more
semanticscholar +1 more source
Cues to opening mechanisms from in silico electric field excitation of cx26 hemichannel and in vitro mutagenesis studies in HeLa transfectans [PDF]
, 2018 Connexin channels play numerous essential roles in virtually every organ by mediating solute exchange between adjacent cells, or between cytoplasm and extracellular milieu.
Bruno, Francesca +7 more
core +1 more source
Mechanisms Underlying Connexin Hemichannel Activation in Disease [PDF]
International Journal of Molecular Sciences, 2021 Gap junctions and connexin hemichannels mediate intercellular and extracellular communication, respectively. While gap junctions are seen as the “good guys” by controlling homeostasis, connexin hemichannels are considered as the “bad guys”, as their activation is associated with the onset and dissemination of disease.
Raf Van Campenhout +5 more
openaire +3 more sources
An Update on Connexin Gap Junction and Hemichannels in Diabetic Retinopathy
International Journal of Molecular Sciences, 2021 Diabetic retinopathy (DR) is one of the main causes of vision loss in the working age population. It is characterized by a progressive deterioration of the retinal microvasculature, caused by long-term metabolic alterations inherent to diabetes, leading ...
J. González-Casanova +5 more
semanticscholar +1 more source
Single and fractionated ionizing radiation induce alterations in endothelial connexin expression and channel function [PDF]
, 2019 Radiotherapy is an effective treatment for most tumor types. However, emerging evidence indicates an increased risk for atherosclerosis after ionizing radiation exposure, initiated by endothelial cell dysfunction. Interestingly, endothelial cells express
Aerts, An +8 more
core +2 more sources
Frontiers in Neurology, 2020 Ischemic stroke is a multi-factorial cerebrovascular disease with high worldwide morbidity and mortality. In the past few years, multiple studies have revealed the underlying mechanism of ischemia/reperfusion injury, including calcium overload, amino ...
Zhen Liang +7 more
semanticscholar +1 more source
Harnessing the Therapeutic Potential of Antibodies Targeting Connexin Hemichannels.
Biochimica et Biophysica Acta - Molecular Basis of Disease, 2021 BACKGROUND Connexin hemichannels have been implicated in pathology-promoting conditions, including inflammation, numerous widespread human diseases, including cancer and diabetes, and several rare diseases linked to pathological point mutations ...
D. Buratto +3 more
semanticscholar +1 more source
Connexin hemichannels and cell-cell channels: comparison of properties
Brazilian Journal of Medical and Biological Research, 2000 Connexin46 (Cx46) forms functional hemichannels in the absence of contact by an apposed hemichannel and we have used these hemichannels to study gating and permeation at the single channel level with high time resolution.
V.K. Verselis +2 more
doaj +1 more source