Results 51 to 60 of about 6,486 (158)

Regulation of Connexin Hemichannels by Monovalent Cations [PDF]

The Journal of General Physiology, 2005
Opening of connexin hemichannels in the plasma membrane is highly regulated. Generally, depolarization and reduced extracellular Ca2+ promote hemichannel opening. Here we show that hemichannels formed of Cx50, a principal lens connexin, exhibit a novel form of regulation characterized by extraordinary sensitivity to extracellular monovalent cations ...
Srinivas, Miduturu, Calderon, D. Paola, Kronengold, Jack, Verselis, Vytas K.   +3 more
openaire   +2 more sources

Supporting Cells and Their Potential Roles in Cisplatin-Induced Ototoxicity

Frontiers in Neuroscience, 2022
Cisplatin is a known ototoxic chemotherapy drug, causing irreversible hearing loss. Evidence has shown that cisplatin causes inner ear damage as a result of adduct formation, a proinflammatory environment and the generation of reactive oxygen species ...
Sofia Waissbluth, Juan Cristóbal Maass, Helmuth A. Sanchez, Agustín D. Martínez   +3 more
doaj   +1 more source

Connexin and pannexin hemichannels of neurons and astrocytes [PDF]

Channels, 2008
Hemichannels are large pore ion channels that in the traditional view are formed when half a gap connexin junction opens to the extracellular space. It is now evident that other ion channel families, including the newly discovered pannexin family can form channels with all the nascent properties of hemichannels.
Roger J, Thompson, Brian A, Macvicar
openaire   +2 more sources

Connexons and pannexons: newcomers in neurophysiology

Frontiers in Cellular Neuroscience, 2014
Connexin hemichannels are single membrane channels which have been traditionally thought to work in pairs to form gap junction channels across two opposing cells.
Giselle eCheung, Oana eChever, Nathalie eRouach   +2 more
doaj   +1 more source

Voltage-dependent facilitation of Cx46 hemichannels

American Journal of Physiology-Cell Physiology, 2010
Gap junction channels are formed by two hemichannels in series (one from each neighboring cell), which are in turn connexin hexamers. Under normal conditions, hemichannels at the plasma membrane are mostly closed but can be opened by changes in membrane voltage, extracellular divalent ion concentration, phosphorylation, pH, and redox potential ...
Retamal, Mauricio A., Yin, ShengYong, Altenberg, Guillermo A., Reuss, Luis   +3 more
openaire   +5 more sources

Modulation of Cx46 hemichannels by nitric oxide

American Journal of Physiology-Cell Physiology, 2009
Gap-junction hemichannels are composed of six protein subunits (connexins). Undocked hemichannels contribute to physiological autocrine/paracrine cell signaling, including release of signaling molecules, cell-volume regulation, and glucose uptake.
Retamal, Mauricio A., Yin, ShengYong, Altenberg, Guillermo A., Reuss, Luis   +3 more
openaire   +5 more sources

Calcium Regulation of Connexin Hemichannels

International Journal of Molecular Sciences
Connexin hemichannels (HCs) expressed at the plasma membrane of mammalian cells are of paramount importance for intercellular communication. In physiological conditions, HCs can form gap junction (GJ) channels, providing a direct diffusive path between neighbouring cells.
Erva Bayraktar, Diego Lopez-Pigozzi, Mario Bortolozzi   +2 more
openaire   +3 more sources

The Neuroglial Dialog Between Cannabinoids and Hemichannels [PDF]

Frontiers in Molecular Neuroscience, 2018
The formation of gap junctions was initially thought to be the central role of connexins, however, recent evidence had brought to light the high relevance of unopposed hemichannels as an independent mechanism for the selective release of biomolecules during physiological and pathological conditions.
Valeria C. Labra, Valeria C. Labra, Cristian A. Santibáñez, Cristian A. Santibáñez, Rosario Gajardo-Gómez, Rosario Gajardo-Gómez, Esteban F. Díaz, Esteban F. Díaz, Gonzalo I. Gómez, Gonzalo I. Gómez, Juan A. Orellana, Juan A. Orellana   +11 more
openaire   +4 more sources

Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage

Biological Research
Background Alcohol, a widely abused drug, significantly diminishes life quality, causing chronic diseases and psychiatric issues, with severe health, societal, and economic repercussions. Previously, we demonstrated that non-voluntary alcohol consumption
Gonzalo I. Gómez, Tanhia F. Alvear, Daniela A. Roa, Arantza Farias-Pasten, Sergio A. Vergara, Luis A. Mellado, Claudio J. Martinez-Araya, Juan Prieto-Villalobos, Claudia García-Rodríguez, Natalia Sánchez, Juan C. Sáez, Fernando C. Ortíz, Juan A. Orellana   +12 more
doaj   +1 more source

Analysis of Hemichannels and Gap Junctions: Application and Extension of the Passive Transmembrane Ion Transport Model

Frontiers in Cellular Neuroscience, 2021
Electrical synaptic transmission is an essential form of interneuronal communication which is mediated by gap junctions that permit ion flow. Three gene families (connexins, innexins, and pannexins) have evolved to form gap junctional channels.
Qiqian Wang, Shenquan Liu
doaj   +1 more source