Redox Biology, 2016 Connexin (Cx) hemichannels regulate many cellular processes with little information available regarding their mechanisms. Given that many pathological factors that activate hemichannels also disrupts the integrity of cellular junctions, we speculated a ...
Yuan Chi +6 more
doaj +1 more source
Large-pore connexin hemichannels function like molecule transporters independent of ion conduction
Proceedings of the National Academy of Sciences of the United States of AmericaSignificance The mechanism behind molecule permeation through large-pore connexin hemichannels remains enigmatic. The current perspective posits that ions and molecules diffuse simultaneously, with molecule selectivity and permeability mainly relying on ...
P. Gaete +10 more
semanticscholar +1 more source
Differential sensitivity of brainstem vs cortical astrocytes to changes in pH reveals functional regional specialization of astroglia [PDF]
, 2013 Astrocytes might function as brain interoceptors capable of detecting different (chemo)sensory modalities and transmitting sensory information to the relevant neural networks controlling vital functions.
Castaldo, C +6 more
core +2 more sources
Gap junction proteins and their role in spinal cord injury [PDF]
, 2015 © 2015 Tonkin, Mao, O'Carroll, Nicholson, Green, Gorrie and Moalem-Taylor. Gap junctions are specialized intercellular communication channels that are formed by two hexameric connexin hemichannels, one provided by each of the two adjacent cells.
Gorrie, CA +6 more
core +6 more sources
Detecting CO2-Sensitive Hemichannels in Neurons in Acute Brain Slices
STAR Protocols, 2020 Summary: This protocol provides two independent methods to functionally detect the neuronal expression of CO2-sensitive hemichannels. These hemichannels (consisting of connexins 26 or 30) are directly gated by CO2, independent of pH changes and until ...
Emily Hill, Nicholas Dale, Mark J. Wall
doaj +1 more source
Osmotic Edema Rapidly Increases Neuronal Excitability Through Activation of NMDA Receptor-Dependent Slow Inward Currents in Juvenile and Adult Hippocampus. [PDF]
, 2015 Cellular edema (cell swelling) is a principal component of numerous brain disorders including ischemia, cortical spreading depression, hyponatremia, and epilepsy.
Binder, Devin K +5 more
core +3 more sources
Voltage-dependent facilitation of Cx46 hemichannels
American Journal of Physiology-Cell Physiology, 2010 Gap junction channels are formed by two hemichannels in series (one from each neighboring cell), which are in turn connexin hexamers. Under normal conditions, hemichannels at the plasma membrane are mostly closed but can be opened by changes in membrane voltage, extracellular divalent ion concentration, phosphorylation, pH, and redox potential ...
Retamal, Mauricio A. +3 more
openaire +5 more sources
Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases
BMEMat, EarlyView.This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou +6 more
wiley +1 more source
Role of Pannexin-1 hemichannels and purinergic receptors in the pathogenesis of human diseases
Frontiers in Physiology, 2014 In the last decade several groups have determined the key role of hemichannels formed by pannexins or connexins, extracellular ATP and purinergic receptors in physiological and pathological conditions.
Stephani eVelasquez +3 more
doaj +1 more source
Pathogenic connexin-31 forms constitutively active hemichannels to promote necrotic cell death. [PDF]
PLoS ONE, 2012 Mutations in Connexin-31 (Cx31) are associated with multiple human diseases including erythrokeratodermia variabilis (EKV). The molecular action of Cx31 pathogenic mutants remains largely elusive.
Jingwei Chi +7 more
doaj +1 more source