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Hemichannel and Junctional Properties of Connexin 50 [PDF]
Biophysical Journal, 2002 Lens fiber connexins, cx50 and cx46 (alpha3 and alpha8), belong to a small subset of connexins that can form functional hemichannels in nonjunctional membranes. Knockout of either cx50 or cx46 results in a cataract, so the properties of both connexins are likely essential for proper physiological functioning of the lens.
Beahm, Derek L., Hall, James E.
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Electrophysiology of Single and Aggregate Cx43 Hemichannels
PLoS ONE, 2012 Connexin43 (Cx43) is the most ubiquitous gap junction protein in the human body and is essential for cell-to-cell communication in a variety of organs and organ systems. As a result, Cx43 is responsible for mediating both electrical and chemical signals, passing dissolved solutes and small signaling molecules between cells in a coordinated fashion ...
Cole Brokamp +3 more
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Neuronal involvement in muscular atrophy
Frontiers in Cellular Neuroscience, 2014 The innervation of skeletal myofibers exerts a crucial influence on the maintenance of muscle tone and normal operation. Consequently, denervated myofibers manifest atrophy, which is preceded by an increase in sarcolemma permeability.
Bruno Alejandro Cisterna +4 more
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Dye-uptake Experiment through Connexin Hemichannels
Bio-Protocol, 2014 Connexins (Cxs) are integral membrane proteins of vertebrates that associate to form hexameric transmembrane channels, named hemichannels. Twenty-one Cx types have been described, which are named according to their molecular weight.
Andrea Puhar, Philippe Sansonetti
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Restraint stress increases hemichannel activity in hippocampal glial cells and neurons
Frontiers in Cellular Neuroscience, 2015 Stress affects brain areas involved in learning and emotional responses, which may contribute in the development of cognitive deficits associated with major depression.
Juan Andrés Orellana +6 more
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Motifs in the permeation pathway of connexin channels mediate Ca2+ and voltage sensing.
Frontiers in Physiology, 2014 Connexin channels mediate electrical coupling, intercellular molecular signaling and extracellular release of signaling molecules. Connexin proteins assemble intracellularly as hexamers to form plasma membrane hemichannels.
Andrew L. Harris, Jorge E. Contreras
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Connexin43 Hemichannel-Mediated Regulation of Connexin43
PLoS ONE, 2013 Many signaling molecules and pathways that regulate gap junctions (GJs) protein expression and function are, in fact, also controlled by GJs. We, therefore, speculated an existence of the GJ channel-mediated self-regulation of GJs. Using a cell culture model in which nonjunctional connexin43 (Cx43) hemichannels were activated by cadmium (Cd(2+)), we ...
Kai Li +7 more
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Antidepressants impact connexin 43 channel functions in astrocytes
Frontiers in Cellular Neuroscience, 2016 Glial cells, and in particular astrocytes, are crucial to maintain neuronal microenvironment by regulating energy metabolism, neurotransmitter uptake, gliotransmission and synaptic development.
Tiffany eJeanson +6 more
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Frontiers in Cellular Neuroscience, 2018 Astrocytes from the hippocampus of chronic epileptic rats exhibit an abnormal pattern of intracellular calcium oscillations, characterized by an augmented frequency of long lasting spontaneous Ca2+ transients, which are sensitive to purinergic receptor ...
Mario Wellmann +8 more
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Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease
Frontiers in Cellular Neuroscience, 2019 Oligodendrocytes are the myelin forming cells in the central nervous system (CNS). In addition to this main physiological function, these cells play key roles by providing energy substrates to neurons as well as information required to sustain proper ...
Sebastián Vejar +7 more
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